Hypoxia-Inducible Factors Regulate Osteoclasts in Health and Disease

Meng, Xianjun; Wielockx, Ben; Rauner, Martina; Bözec, Aline

doi:10.3389/fcell.2021.658893

Cited by 15 publications

(8 citation statements)

References 100 publications

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“…The coatings in this review discussed only those that facilitate cell signaling for cell differentiation. Regulation of soluble growth factors by adjusting oxygen tension [ 314 , 315 ] and further study or combination of it with biophysical or biomechanical stimuli can be beneficial to accelerate bone regeneration [ 316 ].…”

Section: Prospects and Challenges Of Bioactive Coating Systems For Absorbable Magnesium Bone Implantsmentioning

confidence: 99%

Potential bioactive coating system for high-performance absorbable magnesium bone implants

Sarian

Iqbal

Sotoudehbagha

et al. 2022

Bioactive Materials

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Magnesium alloys are considered the most suitable absorbable metals for bone fracture fixation implants. The main challenge in absorbable magnesium alloys is their high corrosion/degradation rate that needs to be controlled. Various coatings have been applied to magnesium alloys to slow down their corrosion rates to match their corrosion rate to the regeneration rate of the bone fracture. In this review, a bioactive coating is proposed to slow down the corrosion rate of magnesium alloys and accelerate the bone fracture healing process. The main aim of the bioactive coatings is to enhance the direct attachment of living tissues and thereby facilitate osteoconduction. Hydroxyapatite, collagen type I, recombinant human bone morphogenetic proteins 2, simvastatin, zoledronate, and strontium are six bioactive agents that show high potential for developing a bioactive coating system for high-performance absorbable magnesium bone implants. In addition to coating, the substrate itself can be made bioactive by alloying magnesium with calcium, zinc, copper, and manganese that were found to promote bone regeneration.

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Section: Prospects and Challenges Of Bioactive Coating Systems For Absorbable Magnesium Bone Implantsmentioning

confidence: 99%

Potential bioactive coating system for high-performance absorbable magnesium bone implants

Sarian

Iqbal

Sotoudehbagha

et al. 2022

Bioactive Materials

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“…Furthermore, there is an association between lower osteocyte density in human central cancellous bone and increased surface remodeling [17], an independent contributor to bone fragility [18]. Therefore, a primary strategy in finding therapeutic targets to treat osteoporosis involves targeting osteoclasts [19].…”

Section: Osteocyte and Osteoblast Differentiationmentioning

confidence: 99%

Cellular Senescence in Bone

Wang¹,

Wang²

2022

Physiology

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Senescence is an irreversible cell-cycle arrest process induced by environmental, genetic, and epigenetic factors. An accumulation of senescent cells in bone results in age-related disorders, and one of the common problems is osteoporosis. Deciphering the basic mechanisms contributing to the chronic ailments of aging may uncover new avenues for targeted treatment. This review focuses on the mechanisms and the most relevant research advancements in skeletal cellular senescence. To identify new options for the treatment or prevention of age-related chronic diseases, researchers have targeted hallmarks of aging, including telomere attrition, genomic instability, cellular senescence, and epigenetic alterations. First, this chapter provides an overview of the fundamentals of bone tissue, the causes of skeletal involution, and the role of cellular senescence in bone and bone diseases such as osteoporosis. Next, this review will discuss the utilization of pharmacological interventions in aging tissues and, more specifically, highlight the role of senescent cells to identify the most effective and safe strategies.

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“…Hypoxia-inducible factor (HIF) plays an essential role in cellular and systemic oxygen homeostasis via inducing the expression of many hypoxia-responsive genes ( 119 ). HIF-1α mediates hypoxia-signaling cascade to exhibit myocardial protection in MI/R ( 120 ).…”

Section: Sumoylated Proteins In Myocardial Infarctionmentioning

confidence: 99%

SUMOylation as a Therapeutic Target for Myocardial Infarction

Zhao

Zhang

2021

Front. Cardiovasc. Med.

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Myocardial infarction is a prevalent and life-threatening cardiovascular disease. The main goal of existing interventional therapies is to restore coronary reperfusion while few are designed to ameliorate the pathology of heart diseases via targeting the post-translational modifications of those critical proteins. Small ubiquitin-like modifier (SUMO) proteins are recently discovered to form a new type of protein post-translational modifications (PTM), known as SUMOylation. SUMOylation and deSUMOylation are dynamically balanced in the maintenance of various biological processes including cell division, DNA repair, epigenetic transcriptional regulation, and cellular metabolism. Importantly, SUMOylation plays a critical role in the regulation of cardiac functions and the pathology of cardiovascular diseases, especially in heart failure and myocardial infarction. This review summarizes the current understanding on the effects of SUMOylation and SUMOylated proteins in the pathophysiology of myocardial infarction and identifies the potential treatments against myocardial injury via targeting SUMO. Ultimately, this review recommends SUMOylation as a key therapeutic target for treating cardiovascular diseases.

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Hypoxia-Inducible Factors Regulate Osteoclasts in Health and Disease

Cited by 15 publications

References 100 publications

Potential bioactive coating system for high-performance absorbable magnesium bone implants

Potential bioactive coating system for high-performance absorbable magnesium bone implants

Cellular Senescence in Bone

SUMOylation as a Therapeutic Target for Myocardial Infarction

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