Hypoxia Increases Thyroid Cancer Stem Cell‐Enriched Side Population

Mahkamova, Kamilla; Latar, Nani Harlina Md; Aspinall, Sebastian; Meeson, Annette

doi:10.1007/s00268-017-4331-x

Cited by 22 publications

(17 citation statements)

References 37 publications

(29 reference statements)

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“…Both HIF-1α and HIF-2α were reported to be expressed in TC (49). Moreover, a growing evidence points out that hypoxia plays a significant role in the maintenance of thyroid cancer stem cells (CSC) (50). General hypoxia due to diminished vascularization is a well-known characteristic of aging tissues, possibly due to endothelial dysfunction as well decreased function of endothelial progenitor cell function (51,52).…”

Section: Multiple Linear Regression Mega-analysis Results Analysis Fomentioning

confidence: 99%

Aging‑associated genes TNFRSF12A and CHI3L1 contribute to thyroid cancer: An evidence for the involvement of hypoxia as a driver

et al. 2020

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The prevalence of thyroid cancer (TC) is high in the elderly. The present study was based on the hypothesis that genes, which have increased activity with aging, may play a role in the development of TC. A large-scale literature-based data analysis was conducted to explore the genes that are implicated in both TC and aging. Subsequently, a mega-analysis of 16 RNA expression datasets (1,222 samples: 439 healthy controls, and 783 patients with TC) was conducted to test a set of genes associated with aging but not TC. To uncover a possible link between these genes and TC, a functional pathway analysis was conducted, and the results were validated by analysis of gene co-expression. A multiple linear regression (MLR) model was employed to study the possible influence of sample size, population region and study age on the gene expression levels in TC. A total of 262 and 816 genes were identified to have increased activity with aging and TC, respectively; with a significant overlap of 63 genes (P<3.82x10-35). The mega-analysis revealed two aging-associated genes (CHI3L1 and TNFRSF12A) to be significantly associated with TC (P<2.05x10-8), and identified the association with multiple hypoxia-driven pathways through functional pathway analysis, also confirmed by the co-expression analysis. The MLR analysis identified population region as a significant factor contributing to the expression levels of CHI3L1 and TNFRSF12A in TC samples (P<3.24x10-4). The determination of genes that promote aging was warranted due to their possible involvement in TC. The present study suggests CHI3L1 and TNFRSF12A as novel common risk genes associated with both aging and TC.

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Section: Multiple Linear Regression Mega-analysis Results Analysis Fomentioning

confidence: 99%

Aging‑associated genes TNFRSF12A and CHI3L1 contribute to thyroid cancer: An evidence for the involvement of hypoxia as a driver

et al. 2020

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“…Hypoxia also participates in the progression of cancer at further stages of the process. In particular, hypoxia is important in the functioning of cancer stem cells (CSCs) [ 50 , 51 , 52 , 53 , 54 , 55 ], which increase the resistance of the tumor to anticancer therapy. Hypoxia also causes cancer cell migration, invasion and metastasis, partly due to hypoxia causing the epithelial-to-mesenchymal transition (EMT) [ 55 , 56 , 57 , 58 , 59 ].…”

Section: Hypoxia In a Tumormentioning

confidence: 99%

The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors—A Review of Literature

Korbecki

Kojder

Kapczuk

et al. 2021

IJMS

130

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Hypoxia is an integral component of the tumor microenvironment. Either as chronic or cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible factor-1 (HIF-1) and nuclear factor (NF-κB), with cycling hypoxia showing a stronger proinflammatory influence. One of the systems affected by hypoxia is the CXC chemokine system. This paper reviews all available information on hypoxia-induced changes in the expression of all CXC chemokines (CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, CXCL8 (IL-8), CXCL9, CXCL10, CXCL11, CXCL12 (SDF-1), CXCL13, CXCL14, CXCL15, CXCL16, CXCL17) as well as CXC chemokine receptors—CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, CXCR6, CXCR7 and CXCR8. First, we present basic information on the effect of these chemoattractant cytokines on cancer processes. We then discuss the effect of hypoxia-induced changes on CXC chemokine expression on the angiogenesis, lymphangiogenesis and recruitment of various cells to the tumor niche, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), regulatory T cells (Tregs) and tumor-infiltrating lymphocytes (TILs). Finally, the review summarizes data on the use of drugs targeting the CXC chemokine system in cancer therapies.

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“…111 Many studies have reported that HIFs play a critical function in the regulation of the CSC phenotype. [112][113][114][115][116][117] The cells are cultured in the 2D culture system uniform contact with oxygen, which cannot create a continuous oxygen concentration gradient. Thus, the 2D cell culture system does not mimic a hypoxic environment similar to in vivo conditions.…”

Section: Hypoxia and Metabolism In 3d Csc Modelsmentioning

confidence: 99%

3D culture technologies of cancer stem cells: promising ex vivo tumor models

et al. 2020

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Cancer stem cells have been shown to be important in tumorigenesis processes, such as tumor growth, metastasis, and recurrence. As such, many three-dimensional models have been developed to establish an ex vivo microenvironment that cancer stem cells experience under in vivo conditions. Cancer stem cells propagating in three-dimensional culture systems show physiologically related signaling pathway profiles, gene expression, cell–matrix and cell–cell interactions, and drug resistance that reflect at least some of the tumor properties seen in vivo. Herein, we discussed the presently available Cancer stem cell three-dimensional culture models that use biomaterials and engineering tools and the biological implications of these models compared to the conventional ones.

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Hypoxia Increases Thyroid Cancer Stem Cell‐Enriched Side Population

Cited by 22 publications

References 37 publications

Aging‑associated genes TNFRSF12A and CHI3L1 contribute to thyroid cancer: An evidence for the involvement of hypoxia as a driver

Aging‑associated genes TNFRSF12A and CHI3L1 contribute to thyroid cancer: An evidence for the involvement of hypoxia as a driver

The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors—A Review of Literature

3D culture technologies of cancer stem cells: promising ex vivo tumor models

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