Hypoxia enhances LPA-induced HIF-1α and VEGF expression: Their inhibition by resveratrol

Park, Soon Young; Jeong, Kang Jin; Lee, Jangsoon; Yoon, Dae Sung; Choi, Wahn Soo; Kim, Yong Kee; Han, Jeung Whan; Kim, Yoon Mee; Kim, Bum Kyeong; Lee, Hoi Young

doi:10.1016/j.canlet.2007.08.011

Cited by 96 publications

(70 citation statements)

References 19 publications

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“…Resveratrol induced cell death and growth inhibition in A1947, A2780, CaOV3, ES-2, SKOV3 and TOV112D cells by autophagocytosis and inhibition of glycolysis (Opipari et al, 2004;Kueck et al, 2007). Abrogation of HIF-1α and VEGF has been implicated in resveratrol-mediated inhibition of cell migration and angiogenesis in A2780/ CP80, CAOV-3 and ovcar-3 cells (Cao et al, 2004;Park et al, 2007). Resveratrol has also been shown to augment the growth inhibitory effects of other phytoantioxidant, namely indole-3 carbinol (Raj et al, 2008) as well as standard chemotherapeutic drugs, such as cisplatin and doxorubicin (Björklund et al, 2011;Rezk et al, 2006).…”

Section: 1333 Resveratrol Effects On Ovarian Cancer Cells Differ In mentioning

confidence: 99%

Resveratrol Exerts Differential Effects in Vitro and in Vivo against Ovarian Cancer Cells

Stakleff¹,

Sloan²,

Blanco³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Epithelial ovarian cancer represents the most lethal gynecological cancer, and the high mortality rate makes this malignancy a major health concern. Poor prognosis results from an inability to detect ovarian cancers at an early, curable stage, as well as from the lack of an effective therapy. Thus, effective and novel strategies for prevention and treatment with non-toxic agents merit serious consideration. Resveratrol, obtained from grapes, berries, peanuts and red wine, has been shown to have a potent growth-inhibitory effect against various human cancer cells as well as in in vivo preclinical cancer models. The objective here was to evaluate potential antitumor effects of resveratrol in both in vitro and in vivo NuTu-19 ovarian cancer models. In vitro an invasion assay was performed. After 48 h, the numbers of viable cells that invaded the extracellular matrix layer were reduced by 94% with resveratrol in comparison to control. For the in vivo anti-tumor assessment, 10 rats were injected with NuTu-19 cells into the ovarian bursa. Thereafter, half were provided with a diet mixed with a dose of 100 mg resveratrol/kg body weight/day for 28 days. Following sacrifice, anticancer effects were assessed by histological evaluation of ovarian as well as surrounding tissues, and immunohistochemical detection of cell proliferation and apoptosis, but there were no observable differences between the control and resveratrol-treated groups for any of the biological endpoints. While resveratrol is effective in suppressing the in vitro cellular invasion of NuTu-19 ovarian cancer cells, these effects do not appear to impact on in vivo NuTu-19 ovarian cancers in rats.

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Section: 1333 Resveratrol Effects On Ovarian Cancer Cells Differ In mentioning

confidence: 99%

Resveratrol Exerts Differential Effects in Vitro and in Vivo against Ovarian Cancer Cells

Stakleff¹,

Sloan²,

Blanco³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Resveratrol also suppresses expression of inflammatory enzymes, such as iNOS and COX-2, in macrophages and various cancer cells through the inhibition of NF-jB activity [35,40,61]. In ovarian cancer cells, resveratrol inhibits the expression of both basal level and growth factor-induced hypoxia-inducible factor-1a (HIF-1a) [8,45]. The underlying mechanism appears to be associated with the inactivation of mitogenactivated protein kinase (MAPK) and protein translational regulator p70S6K, as well as enhanced degradation of HIF-1a protein through the proteasome pathway.…”

Section: Resveratrolmentioning

confidence: 99%

Modulation of inflammatory signaling pathways by phytochemicals in ovarian cancer

Kim

Han

et al. 2011

Genes Nutr

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Inflammation has been suggested to be involved in cancer development and progression. Many clinical and experimental studies have shown that inflammation could contribute to ovarian carcinogenesis through activation of the NF-jB and AP-1 pathways by chronic inflammatory mediators. Phytochemicals, which are natural compounds derived from fruits and vegetables, have shown anti-inflammatory and anti-cancer effects. Due to their relatively low toxicity and easy accessibility, phytochemicals have been investigated for their chemopreventive potential against various cancers. In this review, we discuss the role of phytochemicals in preventing ovarian cancer through anti-inflammatory mechanisms.

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“…Park et al. (2007) reported RSV‐mediated debilitation of LPA‐induce pathways of tumor migration in ovarian cancer cells. Diminishing of matrix metalloproteinase expression by RSV and concomitant inhibition of diverse cancer cells invasions concluded in several studies.…”

Section: Resveratrol and Diseasesmentioning

confidence: 99%

Resveratrol: A miraculous natural compound for diseases treatment

Koushki

Amiri-Dashatan

Ahmadi

et al. 2018

Food Science & Nutrition

169

109

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Resveratrol (3, 5, 4′‐trihydroxystilbene) is a nonflavonoid polyphenol that naturally occurs as phytoalexin. It is produced by plant sources such as grapes, apples, blueberries, plums, and peanut. This compound has critical roles in human health and is well known for its diverse biological activities such as antioxidant and anti‐inflammatory properties. Nowadays, due to rising incidence of different diseases such as cancer and diabetes, efforts to find novel and effective disease‐protective agents have led to the identification of plant‐derived compounds such as resveratrol. Furthermore, several in vitro and in vivo studies have revealed the effectiveness of resveratrol in various diseases such as diabetes mellitus, cardiovascular disease, metabolic syndrome, obesity, inflammatory, neurodegenerative, and age‐related diseases. This review presents an overview of currently available studies on preventive properties and essential molecular mechanisms involved in various diseases.

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Hypoxia enhances LPA-induced HIF-1α and VEGF expression: Their inhibition by resveratrol

Cited by 96 publications

References 19 publications

Resveratrol Exerts Differential Effects in Vitro and in Vivo against Ovarian Cancer Cells

Resveratrol Exerts Differential Effects in Vitro and in Vivo against Ovarian Cancer Cells

Modulation of inflammatory signaling pathways by phytochemicals in ovarian cancer

Resveratrol: A miraculous natural compound for diseases treatment

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