Hypoxia-Activated PEGylated Paclitaxel Prodrug Nanoparticles for Potentiated Chemotherapy

Hao, Dengyuan; Qian, Meng; Jiang, Bowen; Lu, Shaojin; Xiang, Xiujuan; Pei, Qing; Yu, Haijun; Jing, Xiabin; Xie, Zhigang

doi:10.1021/acsnano.2c05341

Cited by 39 publications

(26 citation statements)

References 52 publications

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“…Cancer is one of the most prominent causes of human death worldwide, with an ever-increasing number of deaths and new cases. 1 The conventional treatment is the use of radiation, 2 medication, 3,4 and surgery to cure a cancer, 5 shrink a cancer or stop the progression of cancer. However, the risk of additional side effects are equally widespread, such as high metastasis and recurrence rate.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Metal–Chalcogenide Agents Enable Synergistic Cancer Therapy via Microwave Thermal-Dynamic Therapy and Immune Cell Activation

Xu,

Wu,

Tan

et al. 2023

ACS Appl. Mater. Interfaces

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Microwave thermal dynamic therapy (MTDT), which combines thermal effects and reactive oxygen species (ROS) by microwave activation, seems to be a promising anticancer therapeutic method. A multifunctional agent for achieving synergistic localized cancer treatment is the key to exploit the strategy to inhibit tumor cell recurrence and metastasis. In the study, a ZIF-67 based theranostic agent loaded with metal−chalcogenide open framework 3 (MCOF3) and heat shock protein 70 (HSP70) as the inner component was studied, coupled with targeting cancer cell membrane (TCM) as the biomimetic outer shell. We found that metal ions in MCOF3 enabled the composite agents to show peroxide-like activity to produce • OH and destroy cancer cells. And then, the microwave (MW) thermal sensitizer of ZIF-67 was used to specifically convert the MW energy into thermal energy and selectively heat the tumor via the cell's targeting. Additionally, the effect of continuous MW thermal therapy has been shown to promote the expression of HSP70, and further activate the effector of CD4 T cell and CD8α T cell. As such, the agents effectively inhibit the tumor cell growth under MW irradiation in vitro and in vivo due to the synergistic effects of MTDT and immune cell activation. The study provides an emerging strategy to ablation cancer effectively.

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Section: Introductionmentioning

confidence: 99%

Biomimetic Metal–Chalcogenide Agents Enable Synergistic Cancer Therapy via Microwave Thermal-Dynamic Therapy and Immune Cell Activation

Xu,

Wu,

Tan

et al. 2023

ACS Appl. Mater. Interfaces

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“…To increase the number of cancer survivors, novel strategies for early cancer diagnosis and treatment are highly desired. The goal of cancer therapy is focused on the effective killing of cancer cells, while normal cells are not harmed. , Despite rapid progress in the understanding of conventional surgical procedures, chemotherapy, radiotherapy, and immunotherapy, great challenges still exist including severe toxic effects, high cost, drug resistance, and low response rates. − Phototherapy is also a powerful treatment pattern, which has attracted tremendous interest with the advantages like noninvasive treatments and limited side effects and drug resistance . Photodynamic therapy (PDT) and photothermal therapy (PTT) are two main strategies applied for phototherapy of cancer. , PDT mainly utilizes reactive oxygen species (ROS) generated from photosensitizers for the destruction of cancer cells and the disruption of microvascular, which has already been sanctioned by the Food and Drug Administration of America (FDA). , ROS molecules ( e.g.…”

Section: Introductionmentioning

confidence: 99%

Black Phosphorus Nanosheets Grafted with Gold Nanorods and Carbon Nanodots for Synergistic Antitumor Therapy

Zhu

Ouyang

Zhao

et al. 2023

ACS Appl. Mater. Interfaces

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Synergetic photothermal/photodynamic/chemotherapy receives significant attention for precise in vivo cancer treatment. Despite plenty of encouraging photosensitizers explored, integrated nanoagents with multiple functions are still highly desired. In this study, novel nanocomposites coupling black phosphorus (BP) nanosheets, gold nanorods (AuNRs), carbon nanodots (CDs), and doxorubicin (Dox) are prepared. The nanoagents exhibit high antitumor activity on account of their broad light absorption, excellent catalytic ability, and significant photothermal and photodynamic effects. CDs not only emit bright fluorescence for accurate diagnosis and guiding of tumor treatment but also catalyze the generation of ROS for photodynamic therapy (PDT). The released Dox induces apoptosis of cells and increases the levels of H2O2 to promote PDT. AuNRs are the main photothermal therapy (PTT) material that converts light into heat. Moreover, BP can be used to enhance both PTT and PDT efficiencies, and the two therapy modes can be cooperatively reinforced. It is also found that the local immune microenvironment of the tumors is activated. The strategy makes good use of the features of each component. Satisfactory antitumor phenomena are well confirmed by in vitro and in vivo results. This study provides new insights into enhanced synergetic therapy, highlighting the great utility of BP-based nanoagents in the field of nanomedicine.

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“…Metal–organic frameworks (MOFs) have recently been exploited for biomedical applications due to their tunable compositions, large porosity, ease of surface functionalization, and biodegradability. − In particular, MOFs have been widely used as drug carriers, − via direct encapsulation of drugs in the pores, , coordination of drugs to metal-cluster secondary building units (SBUs), and covalent conjugation of drugs to the ligands . While the first two methods can have premature drug release due to weak interactions between MOFs and drug molecules, the third method requires an actionable trigger to release the conjugated drug from the MOF. , Among many potential triggers, − X-ray stands out as a great external stimulus due to its deep tissue penetration, image-guided precise dosing, , and radiotherapeutic effects through direct DNA damage or indirect cytotoxic effects via generating reactive oxygen species (ROS). − …”

mentioning

confidence: 99%

Nanoscale Metal–Organic Framework with an X-ray Triggerable Prodrug for Synergistic Radiotherapy and Chemotherapy

Zhen

McCleary

et al. 2023

J. Am. Chem. Soc.

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As heavy-metal-based nanoscale metal–organic frameworks (nMOFs) are excellent radiosensitizers for radiotherapy via enhanced energy deposition and reactive oxygen species (ROS) generation, we hypothesize that nMOFs with covalently conjugated and X-ray triggerable prodrugs can harness the ROS for on-demand release of chemotherapeutics for chemoradiotherapy. Herein, we report the design of a novel nMOF, Hf-TP-SN, with an X-ray-triggerable 7-ethyl-10-hydroxycamptothecin (SN38) prodrug for synergistic radiotherapy and chemotherapy. Upon X-ray irradiation, electron-dense Hf12 secondary building units serve as radiosensitizers to enhance hydroxyl radical generation for the triggered release of SN38 via hydroxylation of the 3,5-dimethoxylbenzyl carbonate followed by 1,4-elimination, leading to 5-fold higher release of SN38 from Hf-TP-SN than its molecular counterpart. As a result, Hf-TP-SN plus radiation induces significant cytotoxicity to cancer cells and efficiently inhibits tumor growth in colon and breast cancer mouse models.

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Hypoxia-Activated PEGylated Paclitaxel Prodrug Nanoparticles for Potentiated Chemotherapy

Cited by 39 publications

References 52 publications

Biomimetic Metal–Chalcogenide Agents Enable Synergistic Cancer Therapy via Microwave Thermal-Dynamic Therapy and Immune Cell Activation

Biomimetic Metal–Chalcogenide Agents Enable Synergistic Cancer Therapy via Microwave Thermal-Dynamic Therapy and Immune Cell Activation

Black Phosphorus Nanosheets Grafted with Gold Nanorods and Carbon Nanodots for Synergistic Antitumor Therapy

Nanoscale Metal–Organic Framework with an X-ray Triggerable Prodrug for Synergistic Radiotherapy and Chemotherapy

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