Hypoxanthine uptake by skeletal muscle microvascular endothelial cells from equilibrative nucleoside transporter 1 (ENT1)-null mice: Effect of oxidative stress

Bone, Derek B J; Antić, M; Quinonez, Diana; Hammond, James R.

doi:10.1016/j.mvr.2014.11.005

Cited by 10 publications

(14 citation statements)

References 42 publications

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“…However, because the term "ENBT1" was previously used to denote a putative transporter and a system that mediates dipyridamole-insensitive hypoxanthine transport in cells such as primary human cardiac microvascular endothelial cells, 34,46,47) the use of "ENBT1" as an alias for SLC43A3 would cause confusion. The present review advocates the use of either SLC43A3 or the same alongside ENBT1.…”

Section: Enbt1/slc43a3mentioning

confidence: 99%

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Molecular Basis of Nucleobase Transport Systems in Mammals

Inoue

2017

Biological & Pharmaceutical Bulletin

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Nucleobases are water-soluble compounds that need specific transporters to cross biological membranes. Cumulative evidence based on studies using animal tissues and cells indicates that the carrier-mediated transport systems for purine and pyrimidine nucleobases can be classified into the following two types: concentrative transport systems that mediate nucleobase transport depending on the sodium ion concentration gradient; and other systems that mediate facilitated diffusion depending on the concentration gradient of the substrate. Recently, several molecular transporters that are involved in both transport systems have been identified. The function and activity of these transporters could be of pharmacological significance considering the roles that they play not only in nucleotide synthesis and metabolism but also in the pharmacokinetics and delivery of a variety of nucleobase analogues used in anticancer and antiviral drug therapy. The present review provides an overview of the recent advances in our understanding of the molecular basis of nucleobase transport systems, focusing on the transporters that mediate purine nucleobases, and discusses the involvement of intracellular metabolism in purine nucleobase transport and chemotherapy using ganciclovir.Key words purine nucleobase; transporter; salvage enzyme; equilibrative nucleoside transporter 1 (ENT1)/ solute carrier (SLC)29A1; ENT2/SLC29A2; equilibrative nucleobase transporter 1 (ENBT1)/ SLC43A3

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Section: Enbt1/slc43a3mentioning

confidence: 99%

“…34,46) The induced SLC43A3 expression may be implicated in inflammation and carcinogenesis. A study on endotoxemia showed that SLC43A3 is one of the six genes that are significantly upregulated in circulating monocytes isolated from healthy volunteers infused with lipopolysaccharide.…”

Section: Enbt1/slc43a3mentioning

confidence: 99%

Molecular Basis of Nucleobase Transport Systems in Mammals

Inoue

2017

Biological & Pharmaceutical Bulletin

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“…Although biflavonoids are known to display a variety of biological activities, such as anti-inflammatory activity, inhibition of cytochrome P450 enzymes, and antiviral activity, their neuroprotective roles have not been known (7,9,16 SOD activity may reduce (1,4,6,14,20). Similarly, we found that the SOD activity in the SA and MP group was significantly increased in comparison to that of the control group.…”

Section: Caspase-3 Expression Of Sciatic Nerve Fibersmentioning

confidence: 51%

“…Likewise, we found that the SA and MP groups exhibited higher NRF-1 values compared to the Sham group. Activation of caspase-3 is known to be important and irreversible in apoptosis caused by ischemia of neuronal cells (3,4,13). Recently, Unsain et al reported that caspase-3 negative axons are protected from degeneration (26).…”

Section: Caspase-3 Expression Of Sciatic Nerve Fibersmentioning

confidence: 99%

“…Ischemia disrupts cellular oxidative phosphorylation process and this in turn causes adenosine triphosphate (ATP)-dependent ionic pump failure and hyperinflux of calcium, sodium, and water into cells (3,8). Meanwhile, adenine nucleotide breakdown is accelerated resulting in intracellular accumulation of hypoxantine which is the precursor of reactive oxygen derivatives (ROD) (4). Additionally, ischemia…”

Section: █ Introductionmentioning

confidence: 99%

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The axon protective effects of syringic acid on ischemia/reperfusion injury in a rat sciatic nerve model

Tokmak¹,

Şehitoğlu²,

Yüksel³

et al. 2015

Turkish Neurosurgery

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Addressing the Clinical Importance of Equilibrative Nucleoside Transporters in Drug Discovery and Development

Hau

Wright

Cherrington

2023

Clin Pharma and Therapeutics

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The US Food and Drug Administration (FDA), European Medicines Agency (EMA), and Pharmaceuticals and Medical Devices Agency (PMDA) guidances on small‐molecule drug–drug interactions (DDIs), with input from the International Transporter Consortium (ITC), recommend the evaluation of nine drug transporters. Although other clinically relevant drug uptake and efflux transporters have been discussed in ITC white papers, they have been excluded from further recommendation by the ITC and are not included in current regulatory guidances. These include the ubiquitously expressed equilibrative nucleoside transporters (ENT) 1 and ENT2, which have been recognized by the ITC for their potential role in clinically relevant nucleoside analog drug interactions for patients with cancer. Although there is comparatively limited clinical evidence supporting their role in DDI risk or other adverse drug reactions (ADRs) compared with the nine highlighted transporters, several in vitro and in vivo studies have identified ENT interactions with non‐nucleoside/non‐nucleotide drugs, in addition to nucleoside/nucleotide analogs. Some noteworthy examples of compounds that interact with ENTs include cannabidiol and selected protein kinase inhibitors, as well as the nucleoside analogs remdesivir, EIDD‐1931, gemcitabine, and fialuridine. Consequently, DDIs involving the ENTs may be responsible for therapeutic inefficacy or off‐target toxicity. Evidence suggests that ENT1 and ENT2 should be considered as transporters potentially involved in clinically relevant DDIs and ADRs, thereby warranting further investigation and regulatory consideration.

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Hypoxanthine uptake by skeletal muscle microvascular endothelial cells from equilibrative nucleoside transporter 1 (ENT1)-null mice: Effect of oxidative stress

Cited by 10 publications

References 42 publications

Molecular Basis of Nucleobase Transport Systems in Mammals

Molecular Basis of Nucleobase Transport Systems in Mammals

The axon protective effects of syringic acid on ischemia/reperfusion injury in a rat sciatic nerve model

Addressing the Clinical Importance of Equilibrative Nucleoside Transporters in Drug Discovery and Development

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