Hypovitaminosis D is associated with a reduction in upper and lower limb muscle strength and physical performance in post-menopausal women: a retrospective study

Iolascon, Giovanni; Sire, Alessandro de; Calafiore, Dario; Moretti, Antimo; Gimigliano, Raffaele; Gimigliano, Francesca

doi:10.1007/s40520-015-0405-5

Cited by 40 publications

(25 citation statements)

References 39 publications

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“…Compromised muscle strength and physical performance is a common manifestation of vitamin D deficiency in generally healthy older individuals 45,46. The current study has shown that serum 25(OH)D concentration is a positive predictor of muscle strength (as measured by grip strength) at both the end of winter and the end of summer, and this association was stronger at the end of summer, when vitamin D status was higher.…”

Section: Discussionsupporting

confidence: 48%

Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study

Carson¹,

Pourshahidi²,

Madigan³

et al. 2018

COPD

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BackgroundOwing to hospitalization, reduced functional capacity and consequently, less sunlight exposure, suboptimal vitamin D status (25-hydroxyvitamin D [25(OH)D]⩽50 nmol/L) is prevalent among COPD patients.ObjectiveThis study aimed to investigate seasonal changes in vitamin D status and any associated changes in fat-free mass (FFM), muscle strength and quality of life (QoL) in COPD patients.Patients and methodsCOPD patients living in Northern Ireland (n=51) completed study visits at the end of winter (March/April) and at the end of summer (September/October), corresponding to the nadir and peak of vitamin D status, respectively. At both time points, serum concentration of 25(OH)D was quantified by liquid chromatography-tandem mass spectrometry, FFM (kg) was measured using bioelectrical impedance and muscle strength (kg) was measured using handgrip dynamometry. QoL was assessed using the validated St George’s Respiratory Questionnaire.ResultsMean±SD 25(OH)D concentration was significantly higher at the end of summer compared to the end of winter (52.5±30.5 nmol/L vs 33.7±28.4 nmol/L, P<0.001); and house- bound patients had significantly lower 25(OH)D concentration compared to nonhousebound patients at the end of summer (42.9±4.2 vs 57.2±9.9 nmol/L; P⩽0.001). Muscle strength (at both time points) and QoL (end of summer only) were positively predicted by 25(OH)D concentration, independent of age, sex and smoking status.ConclusionThis study highlights the need for health policies to include a recommendation for year-round vitamin D supplementation in housebound COPD patients, and wintertime supplementation in nonhousebound patients, to maintain optimal 25(OH)D concentrations to protect musculoskeletal health. Furthermore, an optimal vitamin D status may have potential benefits for QoL in these patients.

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Section: Discussionsupporting

confidence: 48%

Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study

Carson¹,

Pourshahidi²,

Madigan³

et al. 2018

COPD

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show abstract

“…Low levels of vitamin D are associated with a decrease in muscle strength , and vitamin D supplementation has been shown to improve muscle strength and gait, with a reduction in falls . Severe vitamin D deficiency can lead to a reduction in proximal muscle strength and size as well as increased IMNCT .…”

Section: Discussionmentioning

confidence: 99%

“…Increased IMNCT also correlates with a range of measures of neuropathy, including intraepidermal nerve fibre density, suggesting a link with neuropathy rather than its occurrence as a consequence of muscle atrophy. Low levels of vitamin D are associated with a decrease in muscle strength [27], and vitamin D supplementation has been shown to improve muscle strength and gait, with a reduction in falls [28]. Severe vitamin D deficiency can lead to a reduction in proximal muscle strength and size [8] as well as increased IMNCT [7,29].…”

Section: Discussionmentioning

confidence: 99%

Distal lower limb strength is reduced in subjects with impaired glucose tolerance and is related to elevated intramuscular fat level and vitamin D deficiency

et al. 2016

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Aim To quantify muscle strength and size in subjects with impaired glucose tolerance (IGT) in relation to intramuscular non-contractile tissue, the severity of neuropathy and vitamin D level. Methods A total of 20 subjects with impaired glucose tolerance and 20 control subjects underwent assessment of strength and size of knee extensor, flexor and ankle plantar and dorsi-flexor muscles, as well as quantification of intramuscular non-contractile tissue and detailed assessment of neuropathy and serum 25-hydroxy vitamin D levels. Results In subjects with impaired glucose tolerance, proximal knee extensor strength (P=0.17) and volume (P=0.77), and knee flexor volume (P=0.97) did not differ from those in control subjects. Ankle plantar flexor strength was significantly lower (P=0.04) in the subjects with impaired glucose tolerance, with no difference in ankle plantar flexor (P=0.62) or dorsiflexor volume (P=0.06) between groups. Intramuscular non-contractile tissue level was significantly higher in the ankle plantar flexors and dorsiflexors (P=0.03) of subjects with impaired glucose tolerance compared with control subjects, and it correlated with the severity of neuropathy. Ankle plantar flexor muscle strength correlated significantly with corneal nerve fibre density (r= 0.53; P=0.01), a sensitive measure of small fibre neuropathy, and was significantly lower in subjects with vitamin D deficiency (P=0.02). Conclusions People with impaired glucose tolerance have a significant reduction in distal but not proximal leg muscle strength, which is not associated with muscle atrophy, but with increased distal intramuscular non-contractile tissue, small fibre neuropathy and vitamin D deficiency.

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“…In observational studies, optimal serum 25(OH)D levels have been significantly associated with improved musculoskeletal function and muscle strength (Bischoff-Ferrari et al, 2004[6]; Visser et al, 2003[36]). Further, postmenopausal women who were vitamin D deficient presented worse upper and lower limb muscle strength and physical performance compared to vitamin D sufficient control group (Iolascon et al, 2015[21]). Skeletal muscle cells have vitamin D receptor and adequate protein synthesis in these cells, which might be directed through vitamin D function (Holick, 2007[20]).…”

Section: Introductionmentioning

confidence: 99%

The effects of vitamin D supplementation on muscle function among postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

Tabrizi

Hallajzadeh

Mirhosseini

et al. 2019

EXCLI Journal; 18:Doc591; ISSN 1611-2156

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Hypovitaminosis D is associated with a reduction in upper and lower limb muscle strength and physical performance in post-menopausal women: a retrospective study

Abstract: Our results support the hypothesis that there is a significant positive association among serum 25(OH)D3 levels and upper and lower limb muscle functioning.

Cited by 40 publications

References 39 publications

Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study

Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study

Distal lower limb strength is reduced in subjects with impaired glucose tolerance and is related to elevated intramuscular fat level and vitamin D deficiency

The effects of vitamin D supplementation on muscle function among postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

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