The effects of vitamin D supplementation on muscle function among postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

Tabrizi, Reza; Hallajzadeh, Jamal; Mirhosseini, Naghmeh; Lankarani, Kamran Bagheri; Maharlouei, Najmeh; Akbari, Maryam; Asemi, Zatollah

doi:10.17179/excli2019-1386

Cited by 11 publications

(13 citation statements)

References 38 publications

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“…In this meta‐analysis, TUG, an indicator of mobility levels in older adults, demonstrated no changes in response to vitamin D supplementation. Consistent with this observation, other meta‐analyses have reported no differences in mobility levels after daily vitamin D administration with 1000 IU, 25 , 61 while two other meta‐analyses found a minor increase in TUG times (indicating worsening mobility) following vitamin D supplementation. 27 , 28 …”

Section: Discussionsupporting

confidence: 58%

Effect of vitamin D monotherapy on indices of sarcopenia in community‐dwelling older adults: a systematic review and meta‐analysis

Prokopidis

Giannos

Triantafyllidis

et al. 2022

J cachexia sarcopenia muscle

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Background Vitamin D supplementation is proposed as a potentially effective nutritional intervention to mitigate the risk of sarcopenia. The aim of this systematic review and meta-analysis was to investigate the impact of vitamin D supplementation monotherapy on indices of sarcopenia in community-dwelling older adults. Methods A comprehensive search of the literature was conducted in PubMed, Web of Science, Scopus, and Cochrane Library. Eligible randomized controlled trials (RCTs) compared the effect of vitamin D supplementation (as monotherapy) with placebo on indices of sarcopenia in older (>50 years) adults. Using the random effects inverse-variance model, we calculated the mean difference (MD) in handgrip strength (HGS), short physical performance battery (SPPB), timed up and go (TUG), and appendicular lean mass (ALM) between groups. We also calculated the standardized mean difference (SMD) in general muscle strength and general physical performance (composite plot of all muscle strength and physical performance outcomes, respectively) between groups. Results Ten RCTs were included in the meta-analysis. A significant decrease in SPPB scores was observed with vitamin D supplementation compared with placebo (MD: À0.23; 95% CI À0.40 to À0.06; I 2 = 0%; P = 0.007). Vitamin D supplementation conferred no effect on HGS (MD: À0.07 kg; 95% CI À0.70 to 0.55; I 2 = 51%, P = 0.82), TUG (MD: 0.07 s; 95% CI À0.08 to 0.22; I 2 = 0%, P = 0.35), ALM (MD: 0.06 kg/m 2 ; 95% CI: À0.32 to 0.44; I 2 = 73%, P = 0.77), general muscle strength (SMD: À0.01; 95% CI À0.17 to 0.15; I 2 = 42%, P = 0.90), or general physical performance (SMD: À0.02; 95% CI À0.23 to 0.18; I 2 = 71%, P = 0.83). Conclusions Vitamin D supplementation did not improve any sarcopenia indices in community-dwelling older adults and may compromise some aspects of physical performance. Future studies are warranted to investigate the impact of vitamin D supplementation on individual indices of SPPB, including mobility and balance, in older adults.

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Section: Discussionsupporting

confidence: 58%

Effect of vitamin D monotherapy on indices of sarcopenia in community‐dwelling older adults: a systematic review and meta‐analysis

Prokopidis

Giannos

Triantafyllidis

et al. 2022

J cachexia sarcopenia muscle

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“…Despite these association studies and the biological plausibility of the link between vitamin D and muscle health, intervention studies are conflicting. In fact, some meta-analysis and systematic literature reviews have found only modest clinical effects of vitamin D supplements on muscle strength; these non-conclusive results are partially explained by the great inter-study heterogeneity regarding the population included, and the different molecules and doses used for the supplementation [ 143 , 144 , 145 ].…”

Section: Vitamin Dmentioning

confidence: 99%

From the Bench to the Bedside: Branched Amino Acid and Micronutrient Strategies to Improve Mitochondrial Dysfunction Leading to Sarcopenia

Romani

Berger

2022

Nutrients

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With extended life expectancy, the older population is constantly increasing, and consequently, so too is the prevalence of age-related disorders. Sarcopenia, the pathological age-related loss of muscle mass and function; and malnutrition, the imbalance in nutrient intake and resultant energy production, are both commonly occurring conditions in old adults. Altered nutrition plays a crucial role in the onset of sarcopenia, and both these disorders are associated with detrimental consequences for patients (e.g., frailty, morbidity, and mortality) and society (e.g., healthcare costs). Importantly, sarcopenia and malnutrition also share critical molecular alterations, such as mitochondrial dysfunction, increased oxidative stress, and a chronic state of low grade and sterile inflammation, defined as inflammageing. Given the connection between malnutrition and sarcopenia, nutritional interventions capable of affecting mitochondrial health and correcting inflammageing are emerging as possible strategies to target sarcopenia. Here, we discuss mitochondrial dysfunction, oxidative stress, and inflammageing as key features leading to sarcopenia. Moreover, we examine the effects of some branched amino acids, omega-3 PUFA, and selected micronutrients on these pathways, and their potential role in modulating sarcopenia, warranting further clinical investigation.

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“…In this context, the negative correlation noted between VDD and non-HDL in the current study is consistent with the results of some prior studies that assessed the atherogenic profile in obese females. 26 , 33 , 34 Furthermore, a negative association between the 25OHD level and the risk of CAD, including TG and LDL-C, has been suggested in healthy participants and patients. 33 – 35 In this respect, it has been demonstrated that people with normal serum 25OHD have a healthier lipid profile than those with VDD.…”

Section: Discussionmentioning

confidence: 99%

“… 26 , 33 , 34 Furthermore, a negative association between the 25OHD level and the risk of CAD, including TG and LDL-C, has been suggested in healthy participants and patients. 33 – 35 In this respect, it has been demonstrated that people with normal serum 25OHD have a healthier lipid profile than those with VDD.…”

Section: Discussionmentioning

confidence: 99%

The association of coffee consumption rate with serum 25-hydroxyvitamin D, non-HDL levels, and TC/HDL ratio in females with vitamin D deficiency

Habash¹,

Al-Shakhshir²,

Abusamak

et al. 2022

Womens Health (Lond Engl)

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Objectives: The purpose of this study was to evaluate the association of coffee consumption rate with serum 25-hydroxyvitamin D, non-high-density lipoprotein cholesterol levels, and total cholesterol to high-density lipoprotein cholesterol ratio in females with vitamin D deficiency. Methods: This retrospective cross-sectional study was carried out by studying the records of 270 Jordanian females aged 18–65 years with varying degrees of vitamin D deficiency. Following completion of the questionnaire regarding their anthropometric characteristics and coffee consumption rate during the preceding 3 months, the participants were required to provide blood samples for analysis to measure 25-hydroxyvitamin D and lipid profile levels including non-high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol ratio. Results: The current study demonstrated that coffee consumption rate and vitamin D deficiency were significantly positively connected with the total cholesterol to high-density lipoprotein cholesterol ratio ( p = .003) in women with vitamin D deficiency. In addition, vitamin D deficiency alone correlated positively with non-high-density lipoprotein cholesterol levels and the total cholesterol to high-density lipoprotein cholesterol ratio ( p = .010) and ( p = .002), respectively. Conclusion: Higher coffee consumption rate among women with vitamin D deficiency significantly elevated total cholesterol to high-density lipoprotein cholesterol ratio that may increase woman’s risk of hyperlipidemia.

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The effects of vitamin D supplementation on muscle function among postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

Cited by 11 publications

References 38 publications

Effect of vitamin D monotherapy on indices of sarcopenia in community‐dwelling older adults: a systematic review and meta‐analysis

Effect of vitamin D monotherapy on indices of sarcopenia in community‐dwelling older adults: a systematic review and meta‐analysis

From the Bench to the Bedside: Branched Amino Acid and Micronutrient Strategies to Improve Mitochondrial Dysfunction Leading to Sarcopenia

The association of coffee consumption rate with serum 25-hydroxyvitamin D, non-HDL levels, and TC/HDL ratio in females with vitamin D deficiency

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