Hypovitaminosis D in a healthy female population, aged from 40 to 85 years, in the west of Ireland

Lardner, E.; Fitzgibbon, Maria; Wilson, Scott G.; Griffin, D.; Mulkerrin, E.

doi:10.1007/s11845-010-0550-y

Cited by 18 publications

(8 citation statements)

References 30 publications

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“…Deficiency was particularly severe in the West of Ireland with a rate of 59⋅5 % (n 8,738) in those >85 years. The latter finding of low vitamin D status amongst older adults is corroborated by our group (17,(50)(51)(52) . Moreover, high prevalence rates of vitamin D deficiency were more common in nursing homes (NH) residents (50⋅5 %, n 138) and inpatients (45⋅1 %, n 1,055) compared to patients in the community (20⋅3 %, n 3,101) or outpatients (24⋅5 %, n 1,585) (24) .…”

supporting

confidence: 71%

COVID-19: the older adult and the importance of vitamin D sufficiency

O’Shea¹,

Griffin

Brennan

et al. 2020

J Nutr Sci

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In December 2019, in Wuhan, China, the novel coronavirus ‘severe acute respiratory syndrome 2’ (SARS-CoV-2) was discovered as the cause of a pneumonia-like illness and subsequently named coronavirus disease 2019 (COVID-19). COVID-19 spread and is now a global pandemic. With few exceptions, countries in the Northern hemisphere have higher mortality rates from COVID-19. This may be due to an increased prevalence of older people in Northern Europe at higher risk of having cardio-pulmonary and metabolic comorbidities as well as hypovitaminosis D. With increasing age, immunosenescence and ‘inflammaging’ lead to impaired and maladaptive immune responses to SARS-CoV-2 infections, contributing to the enhanced prevalence of severe COVID-19 in older patients. The association of ageing with increased vitamin D deficiency, which is associated with cardiovascular risk factors and disease and worse prognosis in COVID-19 infection, is discussed. Considerable experimental evidence demonstrates the immuno-modulatory properties of vitamin D, in particular, its role in regulating and suppressing the inflammatory cytokine response to viral respiratory infections links the importance of vitamin D sufficiency as a potential protective factor in COVID-19. There is an urgent need for prospective randomised studies to examine whether hypovitaminosis D correlates with severity of COVID-19 disease and the actual benefit of repletion. Moreover, given what has been described as a ‘pandemic of vitamin D deficiency’, especially in Europe, and in the context of the SARS-CoV-2 contagion, the authors support the call for public health doctors and physicians, with support from Governments, to prioritise and strengthen recommendations on vitamin D intake and supplementation.

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supporting

confidence: 71%

COVID-19: the older adult and the importance of vitamin D sufficiency

O’Shea¹,

Griffin

Brennan

et al. 2020

J Nutr Sci

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“…[ 26 ] Whereas few studies have not documented any correlation between age and 25(OH)D levels. [ 27 ]…”

Section: Discussionmentioning

confidence: 99%

Assessment of prevalence of hypovitaminosis D in multiethnic population of the United Arab Emirates

Sridhar

Rao

Multani³

et al. 2016

J Adv Pharm Technol Res

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United Arab Emirates (UAE) has a high prevalence of hypovitaminosis D. Not much data are available regarding the prevalence of Vitamin D deficiency among multiethnic UAE adult population. (1) To determine the prevalence of hypovitaminosis D in multiethnic UAE population (2) To compare the Vitamin D status in Arab and non-Arab population (3) To identify the demographic variables associated with hypovitaminosis D. It was a retrospective study conducted at a secondary care hospital. Electronic case records of all the subjects who had checked their Vitamin D levels during the time period of May 2010–October 2012 were considered for the study. Vitamin D severe deficiency, deficiency, insufficiency, and sufficiency were defined as serum 25-hydroxy Vitamin D (25(OH)D) levels < 10 ng/mL, 10–20 ng/mL, 21–30 ng/mL, and > 30 ng/mL, respectively. A total 425 subjects were included for the data analysis. Vitamin D deficiency was diagnosed in 208 (48.9%) subjects followed by severe Vitamin D deficiency and insufficiency in 141 (33.2%) and 63 (14.8%) subjects, respectively. The overall prevalence of hypovitaminosis D was 96.9%. Negative association (r = −0.196, P < 0.01) was observed between body mass index (BMI) and 25(OH)D levels. Ethnicity was not (P = 0.103) a predictor of 25(OH)D levels. Majority of our study subjects had Vitamin D deficiency. There was no substantial difference in 25(OH)D levels of different ethnic groups. Female gender, age, and BMI were the predictors 25(OH)D levels.

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“…As there is no consensus on the cut-offs used to identify the adequate vitamin D level and assays used for the 25(OH)D assessment differs among studies, making it difficult to compare results, our data are similar to the results of other European studies [ 11 – 16 ]. However in most but not in all [ 17 ] of them a significant seasonal variation has been noted. The lack of the increase in vitamin D level in our population in the summer period seems to be attributed to culture-driven sun avoidance behaviour, clothing habits, scarce outdoor activities, or age-related decrease of vitamin D skin synthesis [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

High prevalence of vitamin D insufficiency in community-dwelling postmenopausal Polish women

Stolarczyk

Horvath

Szczechura

et al. 2014

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IntroductionInadequate vitamin D level is associated with altered bone turnover and bone loss, which increases the fracture risk.AimTo assess the seasonal prevalence of inadequate (insufficient or deficient) serum vitamin D levels in community-dwelling postmenopausal Polish women screened for osteoporosis.Material and methodsA cross-sectional observational study based on the regional urban non-institutionalized sample (n = 107) of postmenopausal Caucasian women in the age range of 51-83 years, not taking any medication and free from any condition likely to affect vitamin D status or calcium/bone metabolism. The outcome measures were the mean 25-OH vitamin D level across all the seasons and the percentage of vitamin D deficiency and insufficiency and defined as < 20 ng/dl (50 nmol/l) and 20-30 ng/dl (50-75 nmol/l), respectively.ResultsNo statistically significant difference has been found in the mean vitamin D level, regardless of the season (p = 0.4). The prevalence of vitamin D deficiency and insufficiency were in spring 54% and 32%, in summer 46% and 46%, in autumn 67% and 27%, and in winter 61% and 22%, respectively.ConclusionsVitamin D inadequacy is common in a sample of Polish community-dwelling postmenopausal women regardless of the season.

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Hypovitaminosis D in a healthy female population, aged from 40 to 85 years, in the west of Ireland

Abstract: Vitamin D status should be assessed more often in middle-aged and older females. Expected age-related and seasonal variations in 25(OH)D levels were not confirmed in this study.

Cited by 18 publications

References 30 publications

COVID-19: the older adult and the importance of vitamin D sufficiency

COVID-19: the older adult and the importance of vitamin D sufficiency

Assessment of prevalence of hypovitaminosis D in multiethnic population of the United Arab Emirates

High prevalence of vitamin D insufficiency in community-dwelling postmenopausal Polish women

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