Hypovitaminosis D Among Healthy Children in the United States

Rovner, Alisha J.; O’Brien, Kimberly

doi:10.1001/archpedi.162.6.513

Cited by 179 publications

(138 citation statements)

References 49 publications

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“…Hypovitaminosis D was very common among Saudi children and adolescents in this study, similarly to findings obtained in the US [15] and Qatar [16]. Interestingly, moderate to severe hypovitaminosis D was already documented as very common among young, normal adult Saudis in 1981 [17].…”

Section: Discussionsupporting

confidence: 89%

Hypovitaminosis D and cardiometabolic risk factors among non-obese youth

et al. 2010

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AbstractHypovitaminosis D and increased cardiometabolic risk have been well established in adults. This study aims to determine whether or not vitamin D also influences cardiometabolic risk in children and adolescents. To test this hypothesis, we recruited 186 boys (mean age 12.4 ± 3.7 years) and 114 girls (11.6 ± 3.7) in a cross-sectional observational study. Anthropometrics were obtained and morning fasting blood samples were collected. Serum glucose and lipid profile were determined using routine methods. Serum 25-hydroxyvitamin D was quantified using an enzyme-linked immunosorbent assay. In our population, approximately 10% of subjects had severe 25-hydroxyvitamin D deficiency (< 12.5 nmol/L), while 50% of the boys and 40% of the girls had mild vitamin D deficiency (12.5–24.9 nmol/L). Circulating 25-hydroxyvitamin D concentrations were inversely correlated with age, body mass index (BMI), blood pressure, waist and hip circumferences and serum triglyceride concentrations, and positively associated with HDL-cholesterol. Age and systolic blood pressure were significant predictors of 25-hydroxyvitamin D, explaining about 30% of the variance (p = 0.0005). In conclusion, significant associations between serum 25-hydroxyvitamin D and cardiometabolic parameters support promising cardioprotective benefits from vitamin D sufficiency at an early age. Follow-up with prospective clinical intervention studies are needed to validate this hypothesis.

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Section: Discussionsupporting

confidence: 89%

Hypovitaminosis D and cardiometabolic risk factors among non-obese youth

et al. 2010

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“…In a study on Costa Rican asthmatic children, 28% showed insufficient levels of vitamin D (,30 ng?mL -1 ), and an inverse relationship was observed between 25-hydroxyvitamin D levels and total immunoglobulin E, eosinophil count, use of anti-inflammatory medication in the previous year, increased airway responsiveness to methacholine and any hospitalisation in the previous year. In our study, only 11% of the patients and 12% of healthy controls had desirable 25-hydroxyvitamin D levels (o30 ng?mL -1 ), and this finding was not completely unexpected, as the study was conducted during the winter/ early-spring time and our town is located at a latitude of 45u279 N. People living above the 35th latitude cannot produce adequate pre-vitamin D3 during the winter [18], and in our country (Italy) foods are not fortified with vitamin D [19]. The fact that almost all our children had insufficient or deficient levels of 25-hydroxyvitamin D is worrying; although those levels have been set for optimal calcium, phosphorus and bone metabolism, there are proposals that concentrations .40 ng?mL -1 (100 nmol?L -1 ) may be essential for optimal immune functioning and overall health [20], but no child in our study population reached such levels.…”

Section: Discussionsupporting

confidence: 46%

Serum vitamin D levels and exercise-induced bronchoconstriction in children with asthma

Chinellato¹,

Piazza²,

Sandri³

et al. 2010

European Respiratory Journal

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Epidemiological studies have established a relationship between low levels of serum vitamin D and reduced lung function in healthy adults, and asthma onset and severity in children. However, no study has examined the relationship between vitamin D levels and exercise-induced bronchoconstriction in asthmatic children.We evaluated the relationship between 25-hydroxyvitamin D concentrations and baseline forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and change in FEV1 (DFEV1) after a standardised exercise challenge in 45 children with intermittent asthma.Only 11% of the children had desirable serum vitamin D levels (at least 30-40 ng?mL Our results indicate that hypovitaminosis D is frequent in asthmatic children who live in a Mediterranean country. In those children, lower levels of vitamin D are associated with reduced lung function and increased reactivity to exercise.

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“…African Americans are more prone to be deficient because of higher skin melanin levels. 70 Vitamin D inadequacy constitutes a largely unrecognized epidemic in many populations worldwide [71][72][73] It has been reported in healthy children, 74 adolescents 75 and adults. 76,77 Vitamin D and prostate health Normal and malignant prostate cells contain VDRs, [78][79][80] which mediate the antiproliferative action of 1,25(OH)2D.…”

Section: Hypovitaminosis Dmentioning

confidence: 99%

Vitamin D and prostate cancer risk: a review of the epidemiological literature

Gupta

Lammersfeld

Trukova

et al. 2009

Prostate Cancer Prostatic Dis

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Prostate cancer is the most commonly diagnosed cancer in the United States. Prostate cells contain vitamin D receptors as well as enzymes necessary for vitamin D metabolism. Vitamin D metabolites have an antiproliferative and a pro-differentiating effect on prostate cancer cell lines in vitro and in vivo. As a result, there has been an emerging interest in the potential role of vitamin D in the etiology of prostate cancer. This review summarizes all available epidemiological literature on the association between dietary vitamin D, circulating levels of vitamin D and sunlight exposure in relation to prostate cancer risk. To place these studies in context, we also provide some background information on vitamin D, such as its dietary sources, metabolism, optimal levels, hypovitaminosis and relationship with the prostate.

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Hypovitaminosis D Among Healthy Children in the United States

Abstract: Although overt vitamin D deficiency is no longer common in US children, lesser degrees of vitamin D insufficiency are widespread.

Cited by 179 publications

References 49 publications

Hypovitaminosis D and cardiometabolic risk factors among non-obese youth

Hypovitaminosis D and cardiometabolic risk factors among non-obese youth

Serum vitamin D levels and exercise-induced bronchoconstriction in children with asthma

Vitamin D and prostate cancer risk: a review of the epidemiological literature

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