Hypouricemia in severely disabled children II: influence of elemental enteral nutrition on the serum uric acid levels

Yoshikawa, Hideto; Yamazaki, Shun; Abe, Tokinari

doi:10.1016/s0387-7604(03)00094-9

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…Phytochemicals have been abundant in human evolutionary nutrition 120 but are not found in tube feedings, the consequences of which have not yet been explored in this context. In people with profound developmental disabilities, there is indirect evidence of increased oxidative stress manifested as low circulating uric acid 121 (circulating uric acid has antioxidant effects), low circulating total glutathione, and elevated urine erythronic acid (unpublished, November 1992–July 1993). We hypothesize that phytochemical deficiencies would result in increased oxidative stress, inflammation, 122 and other abnormalities.…”

Section: Common Biochemical and Nutrient Deficiencies And Their Potenmentioning

confidence: 99%

Potential Benefits of Ameliorating Metabolic and Nutritional Abnormalities in People With Profound Developmental Disabilities

Glick

Fischer

2017

Nutr Metab Insights

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BACkgRouND: People with profound developmental disabilities have some of the most severe neurological impairments seen in society, have accelerated mortality due to huge medical challenges, and yet are often excluded from scientific studies. They actually have at least 2 layers of conditions: (1) the original disability and (2) multiple under-recognized and underexplored metabolic and nutritional imbalances involving minerals (calcium, zinc, and selenium), amino acids (taurine, tryptophan), fatty acids (linoleic acid, docosahexaenoic acid, arachidonic acid, adrenic acid, Mead acid, plasmalogens), carnitine, hormones (insulinlike growth factor 1), measures of oxidative stress, and likely other substances and systems. SuMMARy: This review provides the first list of metabolic and nutritional abnormalities commonly found in people with profound developmental disabilities and, based on the quality of life effects of similar abnormalities in neurotypical people, indicates the potential effects of these abnormalities in this population which often cannot communicate symptoms. key MeSSAgeS: We propose that improved understanding and management of these disturbed mechanisms would enhance the quality of life of people with profound developmental disabilities. Such insights may also apply to people with other conditions associated with disability, including some diseases requiring stem cell implantation and living in microgravity.

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Section: Common Biochemical and Nutrient Deficiencies And Their Potenmentioning

confidence: 99%

Potential Benefits of Ameliorating Metabolic and Nutritional Abnormalities in People With Profound Developmental Disabilities

Glick

Fischer

2017

Nutr Metab Insights

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The effects of sodium valproate on the renal function of children with epilepsy

Knights

Finlay

2013

Pediatr Nephrol

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Sodium valproate is one of the most commonly used drugs to treat epilepsy. However, there is growing evidence that valproate can cause renal tubular injury in children, and there are increasing reports of valproate-induced Fanconi's syndrome where the renal tubules lose their ability to reabsorb electrolytes, urea, glucose and protein. In this review article we attempt to bring together all of the studies conducted to date on the effects of valproate on renal function in epileptic children. The research is generally considered in two themes; the first comprises studies which indicate subclinical tubular injury measured by renal enzymes such as N-acetyl-β-D-glucosaminidase (NAG), and the second comprises clinical reports where Fanconi's syndrome has occurred. This article goes on to analyse the current data and draws on recurring patterns to suggest that a specific subpopulation of severely disabled epileptic children may benefit hugely from the close monitoring of enzymes which are indicative of renal tubular injury, particularly NAG or in the very least periodical urinalysis.

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Hypouricemia: what the practicing rheumatologist should know about this condition

et al. 2019

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Hypouricemia in severely disabled children II: influence of elemental enteral nutrition on the serum uric acid levels

Cited by 5 publications

References 12 publications

Potential Benefits of Ameliorating Metabolic and Nutritional Abnormalities in People With Profound Developmental Disabilities

Potential Benefits of Ameliorating Metabolic and Nutritional Abnormalities in People With Profound Developmental Disabilities

The effects of sodium valproate on the renal function of children with epilepsy

Hypouricemia: what the practicing rheumatologist should know about this condition

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