Hypouricemia: what the practicing rheumatologist should know about this condition

Hypertrophic pulmonary osteoarthropathy due to lung cancer: A case report and literature review

“…19 Although the source of information is not described, some review articles mentioned that arthralgia was more common in the lower limbs in patients with HPOA. 18,23 As indicated in the current case, RS3PE is often considered in the differential diagnosis for paraneoplastic arthralgia. RS3PE is characterized by the following clinical features: (a) rheumatoid factor negativity, (b) occurrence in patients aged >50 years, (c) the presence of acute symmetrical polyarthritis, and (d) the presence of pitting edema on the dorsum of the hands and feet on both sides.…”

“…Segal et al investigated the location of arthralgia in patients with HPOA and reported that 68.8% (11/16) and 87.5% (14/16) of the patients had arthralgia in the upper and lower limbs, respectively 19 . Although the source of information is not described, some review articles mentioned that arthralgia was more common in the lower limbs in patients with HPOA 18,23 …”

Case series on remembering pachydermoperiostosis

“…6 Bisphosphonates were seen effective in reducing the pain and other symptoms related to hypertrophic osteoarthropathies. [6][7][8][9] Pamidronate was reported to be one of promising drug which resulted in a significant pain relief in patients with hypertrophic osteoarthropathies. However, also zoledronic acid can be effective in hypertrophic osteoarthropathies as pain reliefer.…”

Modulation of Urate Transport by Drugs

“…Hypouricemia, recently reviewed in [ 16 ], is a condition characterized by SU levels lower than 2 mg/mL (119 µM). Hypouricemia is traditionally considered a biochemical curiosity with low clinical significance [ 16 ] and clinical guidance on renal hypouricemia has been updated only recently [ 17 ]. Hereditary hypouricemia is most commonly associated with mutations in the SLC22A12/URAT1 and the SLC2A9 / GLUT9 genes [ 18 , 19 ].…”