Hypothyroidism Leads to More Small-Sized Platelets in Circulation

Vandoormaal, Jj; Vandermeer, J; Oosten, Hr; Halie,; Doorenbos, H

doi:10.1055/s-0038-1646037

Cited by 25 publications

(17 citation statements)

References 10 publications

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“…Currently, limited and conflicting data regarding the relationship between thyroid function and MPV have been reported in small-scale case-control studies (17)(18)(19)(20)(21)(22). To our knowledge, no study has been based on a general population, particularly in those who were thought to be healthy and euthyroid.…”

Section: Introductionmentioning

confidence: 74%

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The Mean Platelet Volume Is Positively Correlated with Serum Thyrotropin Concentrations in a Population of Healthy Subjects and Subjects with Unsuspected Subclinical Hypothyroidism

Kim

Park²,

Kim³

et al. 2013

Thyroid

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Section: Introductionmentioning

confidence: 74%

“…Van Doormaal et al (17) found small-sized platelets in overt hypothyroidism, whereas Ford et al (18) did not show smallsized platelets in overt hypothyroidism. Coban et al (19), Erikci et al (20), and Yilamz et al (21) reported an increased MPV in the SCH group compared with the euthyroid states.…”

Section: Kim Et Almentioning

confidence: 97%

The Mean Platelet Volume Is Positively Correlated with Serum Thyrotropin Concentrations in a Population of Healthy Subjects and Subjects with Unsuspected Subclinical Hypothyroidism

Kim

Park²,

Kim³

et al. 2013

Thyroid

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“…Use of platelet volume or size to characterize blood disorders allows detection of more subtle changes in thrombocytopoiesis (24) than platelet count alone. Ford et ale (25) have described an increased mean platelet volume in human hyperthryoid patients, and conversely, van Doormal et ale (26) have reported that small-sized platelets predominate in the hypothyroid state.…”

mentioning

confidence: 95%

Thyroxine Suppresses Thrombocytopoiesis and Stimulates Erythropoiesis in Mice

Sullivan¹,

McDonald²

1992

Experimental Biology and Medicine

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Thyroxine has been shown in vitro to stimulate erythropoiesis by two mechanisms: a direct, beta 2-adrenergic receptor-mediated stimulation of red cell precursors, and an indirect, erythropoietin-mediated mechanism. Clinical reports have suggested that excess thyroxine also exerts depressive effects on thrombocytopoiesis, but the most sensitive methods of assessing platelet production, i.e., percentage of 35S incorporation into platelets and determination of megakaryocyte size and number, are not appropriate for analysis of platelet production in human patients. The purpose of this study was to use a mouse model to investigate the effects of the hyperthyroid state on erythropoiesis and thrombocytopoiesis, and to assess in vivo the two mechanisms by which thyroxine has been described to stimulate erythropoiesis in vitro. We found that thyroxine administration significantly depressed platelet production and stimulated erythropoiesis in mice. Both the D- and L-isomers of thyroxine in appropriate doses produced this depression of thrombocytopoiesis, and the effect was dose dependent for both isomers. Daily administration of thyroxine:increased blood volume; decreased the peripheral platelet count, total circulating platelet count and mass, percentage of 35S incorporation into platelets, and megakaryocyte number and size; and concurrently increased indices of red cell production (packed cell volume, red blood cell count, total circulating red blood cell count and mass, and reticulocyte count). Additionally, propranolol, a nonspecific beta-blocker, partially reversed the suppression of platelet production by L-thyroxine, lending credence to the assertion that the direct, beta 2-adrenergic receptor-mediated stimulation of the erythroid cell line by thyroxine reported to exist in vitro may also be important in vivo.

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“…For example, MPV and platelet distribution width bear importance in the discrimination of myeloproliferative diseases, essential thrombocytosis and reactive thrombocytoses (6,7). Many studies on clinical benefit of MPV were made on many subjects such as splenectomy, microcytic anemia, serebral infarct (8-10), thrombocytopenia (11,12), thrombocytoses (6,7), congenital platelet diseases, sepsis, chronic obstructive lungal diseases (13), chronic venous failure (14), high MPV in hyperthyroidism (15), low MPV in hyperthyroidism (16), hypertension and preeclampsia in pregnanacy, organic solvent toxicity.…”

Section: Introductionmentioning

confidence: 99%