The Mean Platelet Volume Is Positively Correlated with Serum Thyrotropin Concentrations in a Population of Healthy Subjects and Subjects with Unsuspected Subclinical Hypothyroidism

Abstract

The MPV was positively correlated with the TSH level. SCH is an independently associated factor with the highest tertile of MPV in a general Korean population. We propose that the MPV may contribute to the prothrombotic condition that is associated with SCH and perhaps even in putative euthyroid states where the TSH level is the higher part of the normal range.

Lipoprotein (a), Lipid Profile and Mean Platelet Volume in Hypothyroid Patients in Sana'a, Yemen: A Case-Control Study

“…On the other hand, some researchers reported elevated MPV levels in hypothyroid patients (18). Large platelets with increased MPV values are active and release more thromboxane A2 than smaller ones, leading to an increased tendency to thrombosis (18). The absence of a significant difference in the MPV levels in the present study could be attributed to the different strategy of case selection.…”

“…This finding is similar to that observed by Torun et al (27), who found no significant difference in MPV levels between overt hypothyroidism (10.2 fL) and subclinical hypothyroidism (9.4 fL) among nonobese women patients of reproductive age in Sanliurfa, Turkey. On the other hand, some researchers reported elevated MPV levels in hypothyroid patients (18). Large platelets with increased MPV values are active and release more thromboxane A2 than smaller ones, leading to an increased tendency to thrombosis (18).…”

“…This is in agreement with a recent study by Atile et al (32), who reported the absence of association between MPV levels and TSH and FT3 in hypothyroid patients. Limited and conflicting data on the association between thyroid function and MPV have been reported in small-scale case-control studies (18). However, the potential usefulness of MPV as a prognostic marker for venous thromboembolism and various types of arterial thrombosis was concluded in a population-based metanalysis, making it acceptable as a new risk factor for atherosclerosis (32).…”

“…However, this is still controversial, where the majority of studies addressing the MPV role compared patients suffering from myocardial infarction with healthy controls (12). The available data regarding the relationship between thyroid function and MPV are conflicting and limited to small-scale casecontrol studies (18). The increased risk of atherosclerosis and ischemic heart disease associated with hypothyroidism has been partially attributed to dyslipidemia.…”

“…There is increasing evidence that increasing Lp(a), lipid profile and MPV play a pivotal role in developing coronary artery disease (18). Thyroid dysfunction alters the lipid profile through its effect on lipid metabolism.…”