Hypothyroidism in the newborn period

Wassner, Ari J.; Brown, Rosalind S.

doi:10.1097/01.med.0000433063.78799.c2

Cited by 36 publications

(22 citation statements)

References 26 publications

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“…Early diagnosis and knowledge of the diseases may increase the number of families adhering to treatment [4][5][6][9][10][11]15 .…”

Section: Discussionmentioning

confidence: 99%

“…TN is intended to interfere on the course of the disease, thus allowing for specific early treatment and mitigation or elimination of sequelae associated with each disease 4,5 . The PNTN covers, in addition to examinations and detection of diseases, the monitoring and treatment of patients, often for the lifetime 2,3,6,7 . The diseases covered by TP are Congenital Hypothyroidism (CH), Phenylketonuria (PKU), Sickle Cell Disease (SCD) and Cystic Fibrosis (CF).…”

Section: Introductionmentioning

confidence: 99%

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Knowledge of parents regarding newborn screening test, after accessing the website “Babies’ Portal” - Heel prick test

et al. 2017

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Purpose: to assess the knowledge of mothers about the heel prick test, develop contents on this test to make it available on the "Babies' Portal" website, evaluate and validate the informative material developed. Methods: this study was conducted in three stages, that is, the first stage which is about a descriptive study involving 105 mothers of newborn children before performing the neonatal screening "Heel Prick Test", the second one consisting in the development of the website "Babies' Portal", and the third stage, the evaluation and validation of this material carried out by 20 parents of children between zero and 36 months old, who underwent the neonatal screening Heel Prick Test by accessing the website "Babies' Portal". Results: although the interviewed mothers knew that their children had the right to be tested, they showed no knowledge of the diseases that can be prevented, time of diagnosis, nor the consequences arising from the lack of early diagnosis and treatment. The website creation and validation gathered basic information about the Heel Prick Test, and the participants regarded the content from satisfactory to excellent. Conclusion: it is necessary that families know not only about the procedures their children will undergo, but also the reason they are performed and the consequences of failing in doing so.

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“…Early diagnosis and knowledge of the diseases may increase the number of families adhering to treatment [4][5][6][9][10][11]15 .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Knowledge of parents regarding newborn screening test, after accessing the website “Babies’ Portal” - Heel prick test

et al. 2017

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“…It is well known that preterm and/or low-birth-weight babies are at increased risk of CH if exposed not only to iodine excessfrom topical application of iodine antiseptics, but also to iodine deficiency [35]. This may explain why in Quebec no increase in the frequency of preterm babies was found, despite of an increase in CH incidence over the years (from 1:2,850 in 1990-2000 to 1:2,450 in 2001-2009).…”

Section: Discussionmentioning

confidence: 99%

Multiple Factors Influencing the Incidence of Congenital Hypothyroidism Detected by Neonatal Screening

Olivieri

Fazzini²,

Medda³

2015

Horm Res Paediatr

110

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Background/Aims: Over the years a rise in the incidence of congenital hypothyroidism (CH) has been described worldwide. The aim of our study was to investigate trends in the incidence of CH in Italy over the period 1987-2008, and to investigate which factors may have influenced the CH incidence in our country. Methods: Data were derived from the Italian National Registry of Infants with Congenital Hypothyroidism. Since 1998 the laboratory procedures related to neonatal screening for CH have changed drastically. Accordingly, we estimated the CH incidence during the period 1987-1998 (period 1) and the period 1999-2008 (period 2). Results: The incidence of CH confirmed at birth (including transient hypothyroidism) has increased from 1:3,000 liveborn infants in period 1 to 1:1,940 in period 2 (+54%), whereas the incidence of purely permanent CH increased from 1:3,200 to 1:2,320 (+38%). Lowering of the TSH cutoff was the most important factor contributing to the increase of CH incidence in Italy. Moreover, an increment of 58% of preterm babies with permanent CH was found in period 2 compared with period 1. Conclusion: Our results suggest that more than one cause is responsible for the rise in the increasing CH incidence, with lowering of the screening TSH cutoff and an increased survival rate of a growing number of preterm babies both playing an important role.

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“…This update will discuss significant new contributions in the area of congenital hypothyroidism since the topic was last reviewed in June 2013 [1]. Particular attention will be given to the emerging understanding of congenital hypothyroidism in patients with a normally located (eutopic) thyroid gland.…”

Section: Introductionmentioning

confidence: 97%