Hypothyroidism and Ventilator Dependency

Pandya, Kamlesh; Lal, Charanjit; Scheinhorn, David J.; Day, I; Sharma, O. P.

doi:10.1001/archinte.1989.00390090139029

Cited by 18 publications

(3 citation statements)

References 12 publications

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“…It is unclear whether the respiratory muscle weakness can cause chronic or acute-on-chronic alveolar hypoventilation [209], or even need for prolonged mechanical ventilation [213,214]. In the few series of hypothyroid patients who developed ventilatory failure [213,214] it is impossible to differentiate the contributions of respiratory muscle weakness and decreased respiratory drive [215].…”

Section: Copd and Hypothyroidism: Functional Consequencesmentioning

confidence: 99%

“…In the few series of hypothyroid patients who developed ventilatory failure [213,214] it is impossible to differentiate the contributions of respiratory muscle weakness and decreased respiratory drive [215]. Several mechanisms have been postulated as risk factors for the development of alveolar hypoventilation in hypothyroidism (table 3) [213,216].…”

Section: Copd and Hypothyroidism: Functional Consequencesmentioning

confidence: 99%

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Endocrinological derangements in COPD

Laghi

Adıgüzel²,

Tobin³

2009

European Respiratory Journal

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Chronic obstructive pulmonary disease (COPD) is no longer considered to affect only the lungs and airways but also the rest of the body. The systemic manifestations of COPD include a number of endocrine disorders, such as those involving the pituitary, the thyroid, the gonads, the adrenals and the pancreas.The mechanisms by which COPD alters endocrine function are incompletely understood but likely involve hypoxaemia, hypercapnia, systemic inflammation and glucocorticoid administration. Altered endocrine function can worsen the clinical manifestations of COPD through several mechanisms, including decreased protein anabolism, increased protein catabolism, nonenzymatic glycosylation and activation of the rennin-angiotensin-aldosterone system.Systemic effects of endocrine disorders include abnormalities in control of breathing, decreases in respiratory and limb-muscle mass and function, worsening of respiratory mechanics, impairment of cardiac function and disorders of fluid balance.Research on endocrine manifestations of COPD embraces techniques of molecular biology, integrative physiology and controlled clinical trials. A sound understanding of the various disorders of endocrine function associated with COPD is prudent for every physician who practices pulmonary medicine.

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Section: Copd and Hypothyroidism: Functional Consequencesmentioning

confidence: 99%

Section: Copd and Hypothyroidism: Functional Consequencesmentioning

confidence: 99%

Endocrinological derangements in COPD

Laghi

Adıgüzel²,

Tobin³

2009

European Respiratory Journal

View full text Add to dashboard Cite

show abstract

“…Successful weaning from ventilator following correction of hypothyroidism has been reported. (Pandya et al, 1989) Difficulty in weaning can be multifactorial in hypothyroid patients due to the multiple effects exerted by the hormone deficiency on different levels of the respiratory system.…”

Section: Ventilatory Drivementioning

confidence: 99%