Hypothesis to explain the association between hypocalciuria and low circulating 1, 25-dihydroxyvitamin D levels in preeclampsia

Bourges, Héctor; Halhali, Ali

doi:10.1016/0306-9877(93)90238-l

Cited by 8 publications

(10 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, maternal systemic factors may also result in PE through inadequate maternal response to the placenta (65). A role for maternal vitamin D status in PE has been hypothesized since the early 1990s (22), but its mechanism is not known. Most frequently suggested is its regulation of maternal and placental immune responses and cytokines, which could also protect against maternal infections.…”

Section: Maternal Adverse Outcomes Beyond Bone Healthmentioning

confidence: 99%

Vitamin D in Pregnancy and Lactation in Humans

2011

View full text Add to dashboard Cite

Concerns exist about the adequacy of vitamin D in pregnant and lactating women. This review assesses the evidence that maternal vitamin D status influences maternal, fetal, and breast-fed infant bone health; maternal adverse outcomes (preeclampsia, gestational diabetes, obstructed labor, and infectious disease); fetal adverse outcomes (growth, gestational age, and developmental programming); and infant adverse outcomes. The evidence for all of these outcomes is contradictory (except for maternal infectious disease) and lacking causality; thus, it is inconclusive. The 2011 Dietary Reference Intakes for vitamin D and their implications for assessing vitamin D status are discussed. An estimated 5% to 29% of American pregnant women may have inadequate vitamin D status, with the higher prevalence in African Americans. Little is known about the prevalence of inadequacy in American lactating women. Research needs are also identified, especially the need for rigorous and well-designed randomized clinical trials to determine the role of vitamin D in nonbone health outcomes in pregnancy and lactation.

show abstract

Section: Maternal Adverse Outcomes Beyond Bone Healthmentioning

confidence: 99%

Vitamin D in Pregnancy and Lactation in Humans

2011

View full text Add to dashboard Cite

show abstract

“…Early-pregnancy maternal 25(OH)D concentration less than 20 ng/ml was significantly associated with risk of preeclampsia (p<0.001), independent of age, pre pregnancy BMI, education, gravida, socioeconomic status, urban or rural back ground, religion, calcium intake ( Figure 2) This study showed that there was further decrease in 25(OH)D concentration with increasing gestational age, which may be due to a disturbance in local 1α-hydroxylation within the placenta/deciduas and active transplacental transport of Ca to the developing fetus with advancing gestational age [12,13]. August et al also reported reduction in the levels of circulating 1,25(OH)2D in preeclamptic patients compared with normotensive or chronically hypertensive pregnant controls [4].…”

Section: Resultsmentioning

confidence: 71%

Elevated preeclampsia rates during winter with reduced sunlight dependent vitamin D production

Jain¹,

Sweety²,

Shuchi³

et al. 2016

Integr Food Nutr Metab

View full text Add to dashboard Cite

Title: Preeclampsia rates are elevated during winter month when sunlight dependent vitamin D production is reduced. Aim: To assess maternal vitamin D deficiency in early pregnancy and risk of preeclampsia. Settings and Design:Nested case control study. Two maternal blood sample, one at <20 wks and other at term along with cord blood at delivery were taken. Patients were classified into preeclampsia (n=57) and control group (n=178) after abstracting past medical records at delivery. Methods and Material: Vitamin D was estimated by 25-Hydroxyvitamin D 125 I RIA Kit and categorized according to ACOG (2011) criteria. Statistical analysis used: Pearson χ 2 , ANOVA and logistic regression were used. Linear correlation and regression coefficient was used between maternal 25(OH) D at <20 wks and term and cord serum 25(OH)D levels. Results: serum 25(OH)D concentrations in early pregnancy were 56% significantly lower in women who subsequently developed preeclampsia compared with controls (mean, 9.79 ± 4.09 ng/ml , 95% CI, 8.71-10.88 ng/ml, vs. 22.26 ± 15.28 ng/ml and, 95%CI, 20.0-24.52 ng/ml; P<0.001) independent of age, BMI, calcium intake, socioeconomic status, periconceptional multivitamin use, residence. There was 17 times increased risk of preeclampsia in vitamin D deficient mothers compared to controls at early pregnancy and at term. (P<0.001; rr =17.93). Newborns of preeclamptic mothers were more than three times as likely as newborns of controls to have hypovitaminosis D(relative risk 3.55). Conclusions: Maternal vitamin D deficiency is highly prevalent in early pregnancy and is an independent risk factor for preeclampsia.

show abstract

“…Taking into account the higher incidence in winter and a lower incidence in summer, seasonal patterns in PE suggest a role for VD and sunlight [24]. Compared with normal pregnancies, PE is characterized by marked changes in VD and calcium metabolism [21], and already in the early 1990's, a role for VD in the pathogenesis of PE was hypothesized [26]. Women with PE are known to have lower circulating 25(OH)D3 levels than normotensive pregnant women [21][22][23].…”

Section: Gestational Hypertension/preeclampsiamentioning

confidence: 98%

Potential impact of maternal vitamin D status on obstetric well-being

Triunfo

Lanzone

2015

J Endocrinol Invest

View full text Add to dashboard Cite

Despite its discovery 100 years ago, vitamin D (VD) has emerged as one of the most controversial nutrients and prohormones of the 21st century. In the past few years, a growing interest in VD has been observed in the biomedical literature due to evidences demonstrating a relevant relationship not only between regulation of calcium and phosphorus homeostasis, but also multiple disease states and low VD status in the population. Indeed, several studies carried out to decipher its role in the body in almost every cell, tissue, and different organs. Recent findings suggested a significant implication of VD in different physiologic processes , such as vascular health, immune function, metabolism, and placental function. In the attempt to focus the attention on effect of VD on female reproductive health, there has been a paucity of data from randomized controlled trials to establish clear beneficial. Human and animal data suggest that low VD status is associated with impaired fertility, endometriosis, and polycystic ovary syndrome. Findings from observational studies show higher rates of preeclampsia, gestational diabetes, preterm birth, and bacterial vaginosis in women with low VD levels. By recent evidences, this review explored the association between maternal VD status and selected effects on maternal, perinatal, and infant health, and the impact of VD supplementation during pregnancy on obstetric well-being.

show abstract

Hypothesis to explain the association between hypocalciuria and low circulating 1, 25-dihydroxyvitamin D levels in preeclampsia

Cited by 8 publications

References 56 publications

Vitamin D in Pregnancy and Lactation in Humans

Vitamin D in Pregnancy and Lactation in Humans

Elevated preeclampsia rates during winter with reduced sunlight dependent vitamin D production

Potential impact of maternal vitamin D status on obstetric well-being

Contact Info

Product

Resources

About