Hypothermia — Its Use in Severe Carbon Monoxide Poisoning

Thermoregulatory responses to environmental toxicants: The interaction of thermal stress and toxicant exposure

“…In exercising dogs the retained dose of sarin was found to be directly proportional to inhalation volume (McLemore and Craig, 1959). Sarin toxicity is increased at high temperatures, which may be directly related to its actions on peripheral vasomotor tone (Craig et al, 1959b;Stephenson and Kolka, 1990). In Rhesus monkeys a ∼60% increase in sarininduced mortality occurred at 38°C, which correlated with a reduction in skin temperature and a significant increase in T c (as high as 42.4°C in some animals; Craig et al, 1959a).…”

“…The housing of rats in a relatively cool T a of 22°C following DFP poisoning facilitated hypothermia development, which explains the effectiveness of this compound following relatively mild inhibition of AChE (Gordon and Fogelson, 1993). The only clinical case documenting a beneficial effect of induced hypothermia was reported by Craig et al (1959b) involving an 18-year-old man presenting with carbon monoxide poisoning. Carbon monoxide has a 200-fold greater affinity for hemoglobin than oxygen and induces hypoxia at the tissue level that accounts for the clinical symptoms associated with poisoning.…”

Perinatal brain damage : possible therapeutic approaches to hypoxic-ischemic cerebral injury, studied in fetal animals

“…Since lubeluzole is known to inhibit glutamate release during an ischemic insult (24), this drug may be neuroprotective in such an animal model. However, when brain injury is induced by systemic asphyxia the extent and location of neuronal cell loss often vary widely (52)(53)(54) and there is a considerable rise in the fetal abortion rate. Since hardly any neuroprotective effect can be demonstrated under such conditions, we preferred the fetal sheep model of global cerebral ischemia caused by occlusion of both carotid arteries.…”