Hypothermia in Hypoglycemia

Strauch, Barry S.

doi:10.1001/jama.1969.03160280085028

Cited by 26 publications

(10 citation statements)

References 4 publications

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“…Drugs with alpha blockade have been shown to cause hypothermia through inhibitory effect on vasoconstriction (9). In addition to hypotension, confusion, lethargy, and weakness, oral hypoglycemic ingestion can cause hypothermia secondary to neuroglycopenia (10).…”

Section: Dr Jennifer Martindalementioning

confidence: 99%

Altered Mental Status and Hypothermia

Martindale

Senecal

Obermeyer

et al. 2010

The Journal of Emergency Medicine

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Section: Dr Jennifer Martindalementioning

confidence: 99%

Altered Mental Status and Hypothermia

Martindale

Senecal

Obermeyer

et al. 2010

The Journal of Emergency Medicine

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“…This is demonstrated by the fact that many diabetic patients with insulin-induced hypoglycemia have concomitant hypothermia [2,3]. In the early 1980s Gale and colleagues showed that during cold induced shivering and concomitant hypoglycemia energy expenditure (i.e.…”

Section: Introductionmentioning

confidence: 99%

18F-fluorodeoxyglucose uptake in brown adipose tissue during insulin-induced hypoglycemia and mild cold exposure in non-diabetic adults

Schopman¹,

Admiraal²,

Soeters³

et al. 2014

Metabolism

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“…The rise in heat production is caused by increased sympathoadrenal activity and limb muscle blood flow increases through the effects of increased plasma adrenaline. It is thought that skin blood flow increases through withdrawal of vasoconstrictor tone [2] which is at odds with the often reported skin pallor noted in hypoglycaemic subjects.Hypothermia is known to accompany hypoglycaemia in diabetic patients [3] but there is little detailed information of the associated thermoregulatory changes. There are several potential areas where responses in diabetic patients may differ from those of normal subjects: the sympathoadrenal response to hypoglycaemia is attenuated in diabetes of long duration [4], diabetic patients have abnormal vascular responses to a number of different stresses [5], more specifically, there is evidence that skin vascular responses to hypoglycaemia may be abnormal [6] and abnormal sweating is well documented [7].…”

mentioning

confidence: 99%

“…Hypothermia is known to accompany hypoglycaemia in diabetic patients [3] but there is little detailed information of the associated thermoregulatory changes. There are several potential areas where responses in diabetic patients may differ from those of normal subjects: the sympathoadrenal response to hypoglycaemia is attenuated in diabetes of long duration [4], diabetic patients have abnormal vascular responses to a number of different stresses [5], more specifically, there is evidence that skin vascular responses to hypoglycaemia may be abnormal [6] and abnormal sweating is well documented [7].…”

mentioning

confidence: 99%

Thermoregulatory responses to hyperinsulinaemic hypoglycaemia and euglycaemia in IDDM

1994

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SummaryIn healthy subjects hypoglycaemia causes a fall in body temperature through increased sweating and limb blood flow, and despite increased metabolic heat production. We studied thermoregulatory responses to hyperinsulinaemic (100mU.m-2-min -1) (a) hypoglycaemia (2.5mmol/1) and (b) euglycaemia (4.5 mmol/1) in insulin-dependent diabetic men of short (< 5 years) and long (> 15 years) diabetes duration. Plasma noradrenaline (p < 0.0001), metabolic rate (p < 0.005), heart rate (p < 0.0001) and skin blood flow (p < 0.05) increased during hypoglycaemia and euglycaemia with a greater rise in noradrenaline during the former (p < 0.05). Plasma adrenaline (p < 0.005), forearm blood flow (p < 0.05) and systolic blood pressure (p < 0.02) increased and diastolic blood pressure decreased (p < 0.005) during hypoglycaemia, with greater changes in adrenaline (p < 0.05) and diastolic blood pressure in patients of short diabetes duration. Only two patients (diabetes duration < 2 years) sweated appropriately, while body temperature changed minimally in the two groups of patients. In summary, thermoregulatory responses to hypoglycaemia are impaired in IDDM due to attenuated sweating and adrenomedullary responses. [Diabetologia (1994) 37: 689~596]Key words Blood glucose, body temperature, diabetes mellitus insulin.In healthy subjects hypoglycaemia causes a disturbance of thermoregulation: heat is dissipated and core temperature falls despite an increase in heat production [1]. Heat dissipation occurs primarily through sympathetically mediated sweat production and subsequent evaporative heat loss but also by increased peripheral blood flow. The rise in heat production is caused by increased sympathoadrenal activity and limb muscle blood flow increases through the effects of increased plasma adrenaline. It is thought that skin blood flow increases through withdrawal of vasoconstrictor tone [2] which is at odds with the often reported skin pallor noted in hypoglycaemic subjects.Hypothermia is known to accompany hypoglycaemia in diabetic patients [3] but there is little detailed information of the associated thermoregulatory changes. There are several potential areas where responses in diabetic patients may differ from those of normal subjects: the sympathoadrenal response to hypoglycaemia is attenuated in diabetes of long duration [4], diabetic patients have abnormal vascular responses to a number of different stresses [5], more specifically, there is evidence that skin vascular responses to hypoglycaemia may be abnormal [6] and abnormal sweating is well documented [7]. We have therefore examined the thermoregulatory responses to sustained hyperinsulinaemic hypoglycaemia and euglycaemia in IDDM of short and long duration in a single blind, experimental protocol.

show abstract

Hypothermia in Hypoglycemia

Cited by 26 publications

References 4 publications

Altered Mental Status and Hypothermia

Altered Mental Status and Hypothermia

18F-fluorodeoxyglucose uptake in brown adipose tissue during insulin-induced hypoglycemia and mild cold exposure in non-diabetic adults

Thermoregulatory responses to hyperinsulinaemic hypoglycaemia and euglycaemia in IDDM

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