18F-fluorodeoxyglucose uptake in brown adipose tissue during insulin-induced hypoglycemia and mild cold exposure in non-diabetic adults

Schopman, J.E.; Admiraal, Wanda M.; Soeters, Maarten R.; Ackermans, Mariëtte T.; Bisschop, Peter L.H.T.; Frier, Brian M.; Hoekstra, J. B. L.; Romijn, Johannes A.; Verberne, Hein J.; Holleman, F.

doi:10.1016/j.metabol.2014.06.017

Cited by 7 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, our results indicate the protective role of BAT in the cold-induced drop of T ty and brain temperature, but they do not give any idea about the control of core temperature, which could not be measured in the present study due to technical difficulties. Although T ty is liable to change compared with T rec (25), which does not change significantly during mild cold exposure (44), some studies have indirectly suggested a possible involvement of BAT in the control of core temperature (16,40). This is to be explored in the future studies with a well-designed protocol in healthy humans.…”

Section: Discussionmentioning

confidence: 99%

Brown adipose tissue is involved in the seasonal variation of cold-induced thermogenesis in humans

Yoneshiro

Matsushita

Nakae

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Brown adipose tissue (BAT) contributes to whole-body energy expenditure (EE), especially cold-induced thermogenesis (CIT), in humans. Although it is known that EE and CIT vary seasonally, their relationship with BAT has not been investigated. In the present study, we examined the impact of BAT on seasonal variations of EE/CIT and thermal responses to cold exposure in a randomized crossover design. Forty-five healthy male volunteers participated, and their BAT was assessed by positron emission tomography and computed tomography. CIT, the difference of EE at 27ºC and after 2-h cold exposure at 19ºC, significantly increased in winter compared to summer, being greater in subjects with metabolically active BAT (High BAT, 185.6 kcal/d, 18.3 kcal/d, P<0.001) than those without (Low BAT, 90.6 kcal/d, -46.5 kcal/d, P<0.05). Multivariate regression analysis revealed a significant interaction effect between season and BAT on CIT (P<0.001). The cold-induced drop of tympanic temperature (T) and skin temperature (T) in the forehead region and in the supraclavicular region close to BAT deposits were smaller in the High BAT group than in the Low BAT group in winter but not in summer. In contrast, the drop of Tin the subclavicular and peripheral regions distant from BAT was similar in the two groups in both seasons. In conclusion, CIT increased from summer to winter in a BAT-dependent manner, paralleling cold-induced changes in T/T, indicating a role of BAT in seasonal changes in the thermogenic and thermal responses to cold exposure in humans.

show abstract

Section: Discussionmentioning

confidence: 99%

Brown adipose tissue is involved in the seasonal variation of cold-induced thermogenesis in humans

Yoneshiro

Matsushita

Nakae

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…Another theoretical hypothesis could be that the weight gain was the result of the decreased energy expenditure induced by hypoglycaemia. However, it has been observed that energy expenditure increased during insulin‐induced hypoglycaemia in healthy subjects . To the best of our knowledge, no data are available for individuals with longstanding T1D.…”

Section: Discussionmentioning

confidence: 99%

Non‐severe hypoglycaemia is associated with weight gain in patients with type 1 diabetes: Results from the Diabetes Control and Complication Trial

Bumbu

Moutairou

Matar

et al. 2018

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

It is unclear whether the frequent non-severe episodes of hypoglycaemia observed during intensive glucose control in individuals with type 1 diabetes (T1D) are associated with subsequent weight gain. We analysed the association between non-severe hypoglycaemia and weight gain in 1441 Diabetes Control and Complication Trial (DCCT) participants. Non-severe hypoglycaemia was assessed by hypo-score (ie, number of blood glucose values <70 mg/dL divided by the total number of measurements during the DCCT quarterly visits). Significant associations were observed between the hypo-score and annual and total weight gain. The annual weight gain by hypo-score tertiles was 0.8 ± 1.2 (T1), 1.3 ± 1.5 (T2) and 1.4 ± 1.3 kg/y (T3), P < .001 for T2 and T3 vs T1, and for T3 vs T2. The odds ratio for a weight gain of 1.8 kg/y was 2.14 (95% CI, 1.56-2.93) for T2, and 2.53 (95%CI, 1.85-3.45) for T3 vs T1. These differences in weight gain and in risk of weight gain remained significant after adjustment for sex, age, duration of diabetes, HbA1c at baseline and treatment arms. In conclusion, our analysis shows a significant association between non-severe hypoglycaemia and weight gain in individuals with T1D from the DCCT.

show abstract

“…Metabolic studies performed over the past few decades have typically used either air exposure in environmental chambers, water immersion or a liquid-conditioned suit set at fixed temperatures as experimental cool- [49,127] and individualized cooling protocols using a water-perfused mattress or garment [47,81,89,94,95,128,129] sometimes combined with cold air exposure [73,102,117,[130][131][132][133][134] and liquid-con- N/A 60% [134] 259 MBq Static 18 FDG uptake in BAT: 7.5 × that of brain N/A 31-36%…”

Section: Mbq Staticmentioning

confidence: 99%

A critical appraisal of brown adipose tissue metabolism in humans

Blondin

Labbé

Turcotte

et al. 2015

Clinical Lipidology

View full text Add to dashboard Cite

18F-fluorodeoxyglucose uptake in brown adipose tissue during insulin-induced hypoglycemia and mild cold exposure in non-diabetic adults

Cited by 7 publications

References 31 publications

Brown adipose tissue is involved in the seasonal variation of cold-induced thermogenesis in humans

Brown adipose tissue is involved in the seasonal variation of cold-induced thermogenesis in humans

Non‐severe hypoglycaemia is associated with weight gain in patients with type 1 diabetes: Results from the Diabetes Control and Complication Trial

A critical appraisal of brown adipose tissue metabolism in humans

Contact Info

Product

Resources

About