Hypothermia does not influence liver damage and function in a porcine polytrauma model

Abstract

Induction of hypothermia could not significantly improve hepatic damage during the first 48 h following major trauma. Further studies focusing on multi-organ failure including a longer observation period are required to illuminate the impact of hypothermia on hepatic function in multiple trauma patients.

Pulmonary inflammatory response and immunomodulation to multiple trauma and hemorrhagic shock in pigs

“…While most studies focus on changes within the first hours after trauma [ 11 ], we aimed to investigate the pulmonary inflammatory response (including the effects of induced mild hypothermia) in a clinically relevant porcine model with multiple trauma and moderate (45% blood loss over 90 min) or severe (50% blood loss over 120 min) hemorrhagic shock over 48 hours. Here, we complement findings of our collaborators, whose data demonstrated a time-dependent activation of the inflammatory response to multiple trauma with significant changes in cytokine and alarmin levels, both local (in fracture hematoma and brain tissue) and systemic (in blood serum) [ 24 , 26 – 29 ].…”

“…During the study, four experimental animals died within the first 12 hours of the study protocol and were excluded from this analysis (two in Trauma 1 NT, two in Trauma 2 HT). Physiological parameters, clinical characteristics, and mortality have previously been described [24,[26][27][28][29].…”

“…In accordance with the principle of restriction, refinement and reduction for animal studies, the data from experimental animals presented in this study has been collected as part of a multi-center study on severe multiple trauma from which different results have been published by our collaborators [24][25][26][27][28][29]. For this investigation, we used data of 60 male pigs (Sus scrofa domesticus) with a mean body weight of 35±5 kg and an age of 3 to 6 months.…”

“…inflammatory response to multiple trauma with significant changes in cytokine and alarmin levels, both local (in fracture hematoma and brain tissue) and systemic (in blood serum) [24,[26][27][28][29].…”

Translational research: what is the value of experimental studies in comparison with clinical studies to help understand clinical problems?

“…The current issues provide examples from a scientifically active and ongoing group named TREAT [18]. This group has been working in multiple research centers, such as Vienna, Marburg, Aachen, Ulm, Frankfurt, Utrecht and Zurich [19][20][21]. The unique feature of this group is a cooperative effort of multiple researchers that have shared the burden of gathering data along with the results of their cooperation.…”