Translational research: what is the value of experimental studies in comparison with clinical studies to help understand clinical problems?

Cinelli, Paolo; Rauen, Katrin; Halvazishadeh, Sascha; Pape, Hans-Christian

doi:10.1007/s00068-018-1003-y

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…This is mainly due to heterogeneous TBI population in clinical trials, inappropriate TBI severity classification depending only on Glasgow Coma Score (GCS), variable outcome parameters in different trials, and the choice of experimental model. 3 The heterogeneity of TBI lies in the fact that the extent of contusions, edema, ischemia, raised intracranial pressure (ICP), hemorrhage, and secondary injury varies from person to person and is difficult to quantify just by the use of GCS.…”

Section: Acute Brain Injurymentioning

confidence: 99%

A Narrative Review on Translational Research in Acute Brain Injury

Mahajan

Kapoor

Prabhakar

2022

J Neuroanaesth Crit Care

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There has been a constant endeavor to reduce the mortality and morbidity associated with acute brain injury. The associated complex mechanisms involving biomechanics, markers, and neuroprotective drugs/measures have been extensively studied in preclinical studies with an ultimate aim to improve the patients' outcomes. Despite such efforts, only few have been successfully translated into clinical practice. In this review, we shall be discussing the major hurdles in the translation of preclinical results into clinical practice. The need is to choose an appropriate animal model, keeping in mind the species, age, and gender of the animal, choosing suitable outcome measures, ensuring quality of animal trials, and carrying out systematic review and meta-analysis of experimental studies before proceeding to human trials. The interdisciplinary collaboration between the preclinical and clinical scientists will help to design better, meaningful trials which might help a long way in successful translation. Although challenging at this stage, the advent of translational precision medicine will help the integration of mechanism-centric translational medicine and patient-centric precision medicine.

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Section: Acute Brain Injurymentioning

confidence: 99%