Hypothalamic volume and asymmetry in the pediatric population: a retrospective MRI study

Işiklar, Sefa; Ozdemir, Senem Turan; Özkaya, Güven; Özpar, Rıfat

doi:10.1007/s00429-022-02542-6

Cited by 11 publications

(5 citation statements)

References 40 publications

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“…Although their study cohort is limited, reported hypothalamic volumes are in line with ours. This is in contrast to the analysis by Isiklar and colleagues, who reported the hypothalamic volume in the pediatric age range [ 41 ]. The hypothalamic volumes reported in their study are larger than in the study by Wu et al and ours.…”

Section: Discussioncontrasting

confidence: 94%

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MRI Volumetric Analysis of the Hypothalamus and Limbic System across the Pediatric Age Span

et al. 2023

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Purpose: Literature is scarce regarding volumetric measures of limbic system components across the pediatric age range. The purpose of this study is to remedy this scarcity by reporting continuous volumetric measurements of limbic system components, and to provide consistent stratification data including age-related trajectories and sex-related differences in the pediatric age range in order to improve the recognition of structural variations that might reflect pathology. Methods: In this retrospective study, MRI sequences of children with normal clinical MRI examinations of the brain acquired between January 2010 and December 2019 were included. Isotropic 3D T1-weighted were processed using FreeSurfer version 7.3. Total brain volume and volumes of the limbic system including the hippocampus, parahippocampal gyrus, amygdala, hypothalamus, cingulate gyrus, entorhinal cortex, anteroventral thalamic nucleus, and whole thalamus were assessed. Parcellated output was displayed with the respective label map overlay and images were visually inspected for accuracy of regional segmentation results. Continuous data are provided as mean and standard deviation with quadratic trendlines and as mean and 95% confidence intervals. Categorical data are presented as integers and percentages (%). Results: A total of 724 children (401 female, 55.4%), with a mean age at time of MRI of 10.9 ± 4.2 years (range: 1.9–18.2 years), were included in the study. For females, the total brain volume increased from 955 ± 70 mL at the age of 2–3 years to 1140 ± 110 mL at the age of 17–18 years. Similarly, the total brain volume increased for males from 1004 ± 83 mL to 1263 ± 96 mL. The maximum volume was noted at 11–12 years for females (1188 ± 90 mL) and at 14–15 years for males (1310 ± 159 mL). Limbic system structures reached their peak volume more commonly between the 13–14 years to 17–18 years age groups. The male cingulate gyrus, entorhinal cortex, and anteroventral thalamic nucleus reached peak volume before or at 9–10 years. Conclusion: This study provides unique age- and sex-specific volumes of the components of the limbic system throughout the pediatric age range to serve as normal values in comparative studies. Quantification of volumetric abnormalities of the limbic system on brain MRI may offer insights into phenotypical variations of diseases and may help elucidate new pathological phenotypes.

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Section: Discussioncontrasting

confidence: 94%

“…The hypothalamic volumes reported in their study are larger than in the study by Wu et al and ours. This discrepancy is possibly related to the different segmentation pipelines used (MRICloud vs. FreeSurfer) [ 4 , 41 ]. Frisosky Abuaf et al reported hypothalamic volumes of 15 healthy adults as percentages of total intracranial volume.…”

Section: Discussionmentioning

confidence: 99%

MRI Volumetric Analysis of the Hypothalamus and Limbic System across the Pediatric Age Span

et al. 2023

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“…Bursa Uludağ University Faculty of Medicine Clinical Research Ethics Committee approved the conduct of this study on 19.01.2022 with the decision number 2022‐2/7. This study cohort included pediatric patients we previously used in other research (Isıklar et al, 2022). Patients in the 0–18 age group who underwent MRI between 2012 and 2020 were retrospectively analyzed using (Picture Archiving and Communication System [PACS], http://pacs.uludag.edu.tr/ZFP).…”

Section: Methodsmentioning

confidence: 99%

“…Committee approved the conduct of this study on 19.01.2022 with the decision number 2022-2/7. This study cohort included pediatric patients we previously used in other research (Isıklar et al, 2022). Pediatric patients with any cerebral or cerebellar pathology other than headache, convulsions, or suspected seizure-like activity only once, were excluded from the study.…”

Section: Bursa Uluda G University Faculty Of Medicine Clinical Resear...mentioning

confidence: 99%

Three dimensional development and asymmetry of the corpus callosum in the 0–18 age group: A retrospective magnetic resonance imaging study

et al. 2022

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Most of the corpus callosum (CC) developmental studies are concerned with its twodimensional structure. Linear and area measurements do not directly assess the CC size but estimate the overall structure from the cross-sectional image. This study investigated age-and sex-related changes in volumetric development and asymmetry of CC from birth to 18. For this retrospective study, we selected 696 patients (329 [47.27%] females) with both 3D-T1-weighted sequence and normal radiological anatomy from patients 0-18 years of age who had brain magnetic resonance imaging (MRI) between 2012 and 2020. The genu, body, splenium, and total volume of CC were calculated using MRICloud. The measurement results of 23 age groups were analyzed with SPSS (ver.28). Total CC volume was 18740.76 ± 4314.06 mm 3 between 0 and 18 years of age, and its ratio to total brain volume (TBV) was 1.70% ± 0.23%. We observed that the total CC volume has six developmental periods 0 years, 1, 2-4, 5-9, 10-16, and 17-18 years. Genu and body grew in five develop-

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“…Therefore, structural magnetic resonance imaging (MRI) studies have been increasingly employed to assess hypothalamic structural integrity in vivo. [12][13][14][15] While these studies have provided preliminary estimates of age and sex effects on hypothalamic volume, the results have been inconsistent, likely due to inclusion of limited age ranges, small sample sizes, and pre-selection of specific (diseased) populations. Hence, more in-depth investigations of the structural integrity of the hypothalamus in relation to age and sex in much larger populations are warranted for a better understanding of the role of this tiny, yet crucial brain structure in health and disease.…”

Section: Introductionmentioning

confidence: 99%

Hypothalamic integrity is associated with age, sex and cognitive function across lifespan: A comparative analysis of two large population-based cohort studies

Xu,

Estrada,

Etteldorf

et al. 2024

Preprint

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Background The hypothalamus is the body's principal homeostatic center. Emerging findings from animal studies suggest that the hypothalamus could also play a crucial role in the modulation of cognition. However, detailed assessments of age and sex effects on hypothalamic structural integrity and its cognitive correlates across the lifespan are still lacking. Therefore, we aimed to investigate hypothalamic structural integrity in relation to age, sex and cognitive performance across lifespan in the general population. Methods We used cross-sectional data from the Rhineland Study (RS) (N=5812, 55.2 ± 13.6 years, 58% women) and the UK Biobank Imaging Study (UKB) (N=45076, 64.2 ± 7.7 years, 53% women), two large-scale population-based cohort studies. Volumes of hypothalamic structures were obtained from 3T structural magnetic resonance images through application of a recently developed automatic parcellation procedure (FastSurfer-HypVINN). The standardized cognitive domain scores were derived from extensive neuropsychological test batteries. We employed multivariable linear regressions to assess age and sex effects on volumes of hypothalamic structures, and to evaluate the associations of these volumes with domain-specific cognitive function. Findings Mean (standard deviation) volumes of the total hypothalamus were 1124.2 mm3 (104.8) in RS and 1102.1 mm3 (119.9) in UKB. With increasing age, the volumes of the total, anterior and posterior hypothalamus, and mammillary bodies decreased (between -1.20 to -0.14 mm3/year in RS and between -3.82 to -0.49 mm3/year in UKB), and of the medial hypothalamus and tuberal region increased (between 0.33 to 0.65 mm3/year in RS and between 0.21 to 0.68 mm3/year in UKB). Volumes of all hypothalamic structures were larger in men compared to women. Larger total hypothalamus volumes were associated with better global cognition (β ± standard error (SE): 0.025 ± 0.017 [RS] and 0.026 ± 0.007 [UKB], both p<0.005), and total memory (0.030 ± 0.022 [RS] and 0.021 ± 0.009 [UKB], both p<0.007), while larger posterior hypothalamus volumes were associated with better global cognition (0.036 ± 0.014 [RS] and 0.028 ± 0.006 [UKB], both p<0.001), and total memory (0.038 ± 0.018 [RS] and 0.020 ± 0.008 [UKB], both p<0.001). Conclusion We found strong age and sex effects on hypothalamic structures, as well as robust associations between these structures and domain-specific cognitive functions. Overall, these findings thus implicate specific hypothalamic subregions as potential therapeutic targets against age-associated cognitive decline.

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Hypothalamic volume and asymmetry in the pediatric population: a retrospective MRI study

Cited by 11 publications

References 40 publications

MRI Volumetric Analysis of the Hypothalamus and Limbic System across the Pediatric Age Span

MRI Volumetric Analysis of the Hypothalamus and Limbic System across the Pediatric Age Span

Three dimensional development and asymmetry of the corpus callosum in the 0–18 age group: A retrospective magnetic resonance imaging study

Hypothalamic integrity is associated with age, sex and cognitive function across lifespan: A comparative analysis of two large population-based cohort studies

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