Hypothalamic Supraoptic and Paraventricular Nuclei

Armstrong, William E.

doi:10.1016/b978-0-12-374245-2.00014-0

Cited by 30 publications

(31 citation statements)

References 216 publications

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“…An interesting possibility is raised by studies indicating a significant increase in the release of OXY (but not VAS) from SO neurons in subordinate male rats encountering dominant aggressive conspecifics (Wotjak et al, 1996 ; Engelmann et al, 1999 ). This finding is made more intriguing by OXY microdialysis data obtained in one of the studies, which revealed a significant encounter-associated increase in OXY in the subordinates in a hypothalamic region just medial to the SO and dorsal to the optic tract (Engelmann et al, 1999 )—a region adjacent to the LHAjvv, and within the path of OXY axons en route to the posterior pituitary (Armstrong, 1995 ); moreover, the increase in OXY release in this region was up to ~320% over basal levels (about double the maximum increase measured from within the SO) and, strikingly, was not associated with an increase in plasma levels of OXY (Engelmann et al, 1999 ). In the same model, a significant increase in VAS but not OXY release in the PVH was measured (also dissociated from neuroendocrine release) (Wotjak et al, 1996 ).…”

Section: Discussionmentioning

confidence: 98%

Connections of the juxtaventromedial region of the lateral hypothalamic area in the male rat

Hahn

Swanson

2015

Front. Syst. Neurosci.

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Evolutionary conservation of the hypothalamus attests to its critical role in the control of fundamental behaviors. However, our knowledge of hypothalamic connections is incomplete, particularly for the lateral hypothalamic area (LHA). Here we present the results of neuronal pathway-tracing experiments to investigate connections of the LHA juxtaventromedial region, which is parceled into dorsal (LHAjvd) and ventral (LHAjvv) zones. Phaseolus vulgaris leucoagglutinin (PHAL, for outputs) and cholera toxin B subunit (CTB, for inputs) coinjections were targeted stereotaxically to the LHAjvd/v.Results: LHAjvd/v connections overlapped highly but not uniformly. Major joint outputs included: Bed nuc. stria terminalis (BST), interfascicular nuc. (BSTif) and BST anteromedial area, rostral lateral septal (LSr)- and ventromedial hypothalamic (VMH) nuc., and periaqueductal gray. Prominent joint LHAjvd/v input sources included: BSTif, BST principal nuc., LSr, VMH, anterior hypothalamic-, ventral premammillary-, and medial amygdalar nuc., and hippocampal formation (HPF) field CA1. However, LHAjvd HPF retrograde labeling was markedly more abundant than from the LHAjvv; in the LSr this was reversed. Furthermore, robust LHAjvv (but not LHAjvd) targets included posterior- and basomedial amygdalar nuc., whereas the midbrain reticular nuc. received a dense input from the LHAjvd alone. Our analyses indicate the existence of about 500 LHAjvd and LHAjvv connections with about 200 distinct regions of the cerebral cortex, cerebral nuclei, and cerebrospinal trunk. Several highly LHAjvd/v-connected regions have a prominent role in reproductive behavior. These findings contrast with those from our previous pathway-tracing studies of other LHA medial and perifornical tier regions, with different connectional behavioral relations. The emerging picture is of a highly differentiated LHA with extensive and far-reaching connections that point to a role as a central coordinator of behavioral control.

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Section: Discussionmentioning

confidence: 98%

Connections of the juxtaventromedial region of the lateral hypothalamic area in the male rat

Hahn

Swanson

2015

Front. Syst. Neurosci.

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“…Different parts of the medial amygdala, including MeA, MePD, and MePV, are known to project to the paraventricular hypothalamic nucleus, and this projection appears to target both the parvocellular (neuroendocrine‐related) and the autonomic parts (Canteras et al, ; Tanaka et al, ; Prewitt and Herman, ; Simerly, ). Through these direct projections, and also indirectly by way of the BST, the medial amygdala may influence hormone release by the adenohypophysis and the activation of the autonomic nervous system (Armstrong, ; Simerly, ). It is likely that different cell types of the medial amygdala are involved in these responses.…”

Section: Development Of the Olfactory/vomeronasal Amygdala In Rodentsmentioning

confidence: 99%

The Olfactory Amygdala in Amniotes: An Evo‐Devo Approach

Abellán

Desfilis

Medina

2013

The Anatomical Record

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In tetrapods, the medial amygdala is a forebrain center that integrates olfactory and/or vomeronasal signals with the endocrine and autonomic systems, playing a key role in different social behaviors. The vomeronasal system has undergone important changes during evolution, which may be behind some interspecies differences in chemosensorymediated social behavior. These evolutionary changes are associated with variations in vomeronasal-recipient brain structures, including the medial amygdala. Herein, we employed an evolutionary developmental biology approach for trying to understand the function and evolution of the medial amygdala. For that purpose, we reviewed published data on fate mapping in mouse, and the expression of orthologous developmental regulatory genes (Nkx2.1, Lhx6, Shh, Tbr1, Lhx9, Lhx5, Otp, and Pax6) in embryos of mouse, chicken, emydid turtles, and a pipid frog. We also analyzed novel data on Lhx9 and Otp in a lacertid lizard. Based on distinct Abbreviations used: AAv 5 anterior amygdala, ventral part; ACo 5 anterior cortical amygdalar area; AHN 5 anterior hypothalamic nucleus; AOB 5 accessory olfactory bulb; AON 5 anterior olfactory nucleus; APH 5 parahippocampal area (chicken); Arc 5 arcopallium (part of the pallial amygdala in chicken); AStr 5 amygdalo-striatal transition area; BAOT 5 bed nucleus of the accessory olfactory bulb; Bas 5 basal nucleus (Meynert); BC 5 basal amygdalar complex; BL 5 basolateral amygdalar nucleus; BLA 5 basolateral amygdalar nucleus, anterior part; BLV 5 basolateral amygdalar nucleus, ventral part; BM 5 basomedial amygdalar nucleus; BMA 5 basomedial amygdalar nucleus, anterior part; BSTia 5 bed nucleus of the stria terminalis, intraamygdaloid part; BSTM 5 bed nucleus of the stria terminalis, medial part; BSTM1 5 dorsolateral subnucleus of BSTM (chicken); BSTM2 5 ventromedial subnucleus of BSTM (chicken); CDL 5 dorsolateral corticoid area (chicken); Ce 5 central amygdala (central amygdalar nucleus); Co 5 cortical amygdalar area (chicken, comparable to ACo of mammals); CPu 5 caudate-putamen; CxA 5 cortico-amygdalar transition area; DC 5 dorsal cortex (reptile); DEn 5 dorsal endopiriform nucleus; EMT 5 prethalamic (or thalamic) eminence; Ent 5 entorhinal cortex; Gaba1 5 g-aminobutyric acid (GABA)-ergic cells; Glu1 5 glutamatergic cells; GP 5 globus pallidus; GPL 5 globus pallidus, lateral part; GPM 5 globus pallidus, medial part; Hb 5 basal hypothalamus; Hip 5 hippocampal formation, rostral olfacto-recipient part; I 5 intercalated cell groups of the amygdale; ic 5 internal capsule; IM 5 intercalated cell groups of the amygdala, main division; L 5 lateral amygdalar nucleus; LC 5 lateral cortex (reptile); LGE 5 lateral ganglionic eminence; LOT 5 nucleus of the lateral olfactory tract; LOT1 5 nucleus of the lateral olfactory tract, layer 1; MC 5 medial cortex (reptile); Me 5 medial amygdala in nonmammals; MeA 5 medial amygdala, anterior part; MeAV 5 medial amygdala, anteroventral part; MePD 5 medial amygdala, posterodorsal part; MePV 5 medial amygdala, posteroven...

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“…The cytological classification of vasopressinergic neurones in the CNS in the last four decades has been established within three frames of reference. These are somatic size (magnocellular vs parvocellular); projection to the neural lobe of the pituitary gland or to the brain; and location of cell bodies either in the classical ‘hormonal’ nuclei of the hypothalamus, such as the PVN, SCN and SON, or within small cell groups at extrahypothalamic locations . Recent findings revealed that the ascending projections of the magnocellular neurosecretory neurones may have profound pro‐motivational and goal‐directed effects projecting monosynaptically to the hippocampus, lateral habenula, amygdala and locus coeruleus in rats under conditions of physiological stress .…”

Section: Discussionmentioning

confidence: 99%

VGLUT‐VGAT expression delineates functionally specialised populations of vasopressin‐containing neurones including a glutamatergic perforant path‐projecting cell group to the hippocampus in rat and mouse brain

Zhang

Hernández

Zetter

et al. 2020

J Neuroendocrinology

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The origin and functional significance of vasopressin (AVP)-containing fibres in limbic regions has been an ongoing subject of investigation for several years. We have previously identified AVP-magnocellular neurones of rat hypothalamus that provide glutamatergic projections to the hippocampus, amygdala, lateral habenula and locus coeruleus. However, we also reported AVP-immunopositive fibres in those regions that are thin and make Gray type II synapses, which are unlikely to be of magnocellular origin. Therefore, in the present study, we characterised AVP mRNA coexpression with expression of mRNAs marking glutamatergic (vesicular glutamate transporter [VGLUT]) and GABAergic (vesicular GABA transporter [VGAT]) neuronal traits in rat and mouse brain, using high-resolution in situ hybridisation methods, including a radio-ribonucleotide and RNAscope 2.5 HD duplex assay, with Slc17a7, Slc17a6, Slc32a1 and Avp probes corresponding to mRNAs of VGLUT1, VGLUT2, VGAT and AVP, respectively. We located 18 cell groups expressing Avp and identified their molecular signatures for VGLUT and VGAT mRNA expression. Avp cell groups of hypothalamus and midbrain are mainly VGLUT mRNA-expressing, whereas those in regions derived from cerebral nuclei are mainly VGAT mRNA-expressing, suggesting a functional segregation of glutamate/GABA co-transmission with AVP. A newly identified Slc17a7 and Slc17a6 (but not Slc32a1) expressing vasopressinergic cell group was found in layer II-III neurones of the central entorhinal cortex, which projects to the hippocampus. These data support the notion of a complex role for AVP with respect to modulating multiple central circuits controlling behaviour in specific ways depending on co-transmission with glutamate or GABA, potentially giving rise to a functional classification of AVPergic neurones in the central nervous system. K E Y W O R D S AVP, electron microscopy, in situ hybridisation, VGAT, VGLUT1, VGLUT2 How to cite this article: Zhang L, Hernández VS, Zetter MA, Eiden LE. VGLUT-VGAT expression delineates functionally specialised populations of vasopressin-containing neurones including a glutamatergic perforant path-projecting cell group to the hippocampus in rat and mouse brain.

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Hypothalamic Supraoptic and Paraventricular Nuclei

Cited by 30 publications

References 216 publications

Connections of the juxtaventromedial region of the lateral hypothalamic area in the male rat

Connections of the juxtaventromedial region of the lateral hypothalamic area in the male rat

The Olfactory Amygdala in Amniotes: An Evo‐Devo Approach

VGLUT‐VGAT expression delineates functionally specialised populations of vasopressin‐containing neurones including a glutamatergic perforant path‐projecting cell group to the hippocampus in rat and mouse brain

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