The Olfactory Amygdala in Amniotes: An Evo‐Devo Approach

Abellán, Antonio; Desfilis, Ester; Medina, Loreta

doi:10.1002/ar.22744

Cited by 42 publications

(102 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although more studies are needed to further investigate the distribution, molecular profile and connections of the neurons in each subcorridor, with the available data it is tempting to suggest that neurons with the same origin along each subcorridor of the EAce share many molecular and connectivity features, and are possibly involved in the same functional network. A similar suggestion has been raised for neurons of distinct embryonic origin of the medial extended amygdala [García-López et al, 2008;Bupesh et al, 2011b;Medina et al, 2011;Medina and Abellán, 2012;Sokolowski and Corbin, 2012;Abellán et al, 2013]. If proven, developmental data may become essential for helping to unravel the otherwise extremely complex chemical and hodological organization of the EAce, and for understanding its involvement in so many, multifaceted functions (fear/anxiety, feeding/satiety, reward/aversion and pain/analgesia).…”

Section: Multiple Cell Subcorridors Inside the Eace: Functional Implimentioning

confidence: 99%

“…In recent years, the embryonic commissural PO, characterized by expression of Nkx2.1, Shh and Lhx7 at the ventricular zone and mantle, has emerged as a major source of neurons for the medial extended amygdala (mouse: García-López et al [2008], Carney et al [2010] and Bupesh et al [2011b] and chicken: Me-dina [2008, 2009] and reviews by Medina et al [2011] and Abellán et al [2013]). More recently, the embryonic commissural PO was also shown to produce a minor subpopulation of catecholaminergic neurons for the EAce and St in mice [Bupesh et al, 2014], and a similar contribution was also suggested to occur in chicken ( fig.…”

Section: Cells Of Po Origin In the Eacementioning

confidence: 99%

See 1 more Smart Citation

Embryonic Origin of the Islet1 and Pax6 Neurons of the Chicken Central Extended Amygdala Using Cell Migration Assays and Relation to Different Neuropeptide-Containing Cells

Vicario

Abellán

Medina³

2015

Brain Behav Evol

Self Cite

View full text Add to dashboard Cite

In a recent study, we tentatively identified different subdivisions of the central extended amygdala (EAce) in chicken based on the expression of region-specific transcription factors (including Pax6 and Islet1) and several phenotypic markers during embryonic development. Such a proposal was partially based on the suggestion that, similarly to the subdivisions of the EAce of mammals, the Pax6 and Islet1 neurons of the comparable chicken subdivisions derive from the dorsal (Std) or ventral striatal embryonic domains (Stv), respectively. To investigate whether this is true, in the present study, we carried out cell migration assays from chicken Std or Stv combined with immunofluorescence for Pax6 or Islet1. Our results showed that the cells of the proposed chicken EAce truly originate in either Std (expressing Pax6) or Stv (expressing Islet1). This includes lateral subdivisions previously compared to the intercalated amygdalar cells and the central amygdala of mammals, also rich in Std-derived Pax6 cells and/or Stv-derived Islet1 cells. In the medial region of the chicken EAce, the dorsal part of the lateral bed nucleus of the stria terminalis (BSTL) contains numerous cells expressing Nkx2.1 (mostly derived from the pallidal domain), but our migration assays showed that it also contains neuron subpopulations from the Stv (expressing Islet1) and Std (expressing Pax6), resembling the mouse BSTL. These findings, together with those previously published in different species of mammals, birds and reptiles, support the homology of the chicken EAce to that of other vertebrates, and reinforce the existence of several cell subcorridors inside the EAce. In addition, together with previously published data on neuropeptidergic cells, these results led us to propose the existence of at least seventeen neuron subtypes in the EAce in rodents and/or some birds (chicken and pigeon). The functional significance and the evolutionary origin of each subtype needs to be analyzed separately, and such studies are mandatory in order to understand the multifaceted modulation by the EAce of fear responses, ingestion, motivation and pain in different vertebrates.

show abstract

Section: Multiple Cell Subcorridors Inside the Eace: Functional Implimentioning

confidence: 99%

Section: Cells Of Po Origin In the Eacementioning

confidence: 99%

Embryonic Origin of the Islet1 and Pax6 Neurons of the Chicken Central Extended Amygdala Using Cell Migration Assays and Relation to Different Neuropeptide-Containing Cells

Vicario

Abellán

Medina³

2015

Brain Behav Evol

Self Cite

View full text Add to dashboard Cite

show abstract

“…This is not surprising since the embryonic origin of any single neuron has a strong influence on its future chemical features, connections and physiological characteristics. In the mouse centromedial extended amygdala, which is highly heterogeneous regarding neuron constitution and embryonic origin, there is also a trend for neurons having the same origin to share similar chemical features and connections, and to be involved in similar functions [García-López et al, 2008;Bupesh et al, 2011a, b;Medina et al, 2011;Abellán et al, 2013]. Thus, developmental studies have provided key information for a better understanding of the functional anatomical organization of the globus pallidus in mammals.…”

Section: The Globus Pallidus In Mammals: Multiple Neurons and Multiplmentioning

confidence: 99%

“…Modern developmental studies using tools for analyzing gene expression, gene function and fate mapping help to understand the embryonic origin and basic features of each neuron subtype of the basal ganglia and other subpallial structures, such as the centromedial extended amygdala [Marín et al, 2000;García-López et al, 2008;Hirata et al, 2009;Carney et al, 2010;Nóbrega-Pereira et al, 2010;Bupesh et al, 2011a, b;Abellán et al, 2013]. In the centromedial amygdala, this information is key to unraveling its functional anatomical organization in mammals and to establish the basis for comparisons with other species [Moreno et al, 2009;Medina et al, 2011;Abellán et al, 2013].…”

Section: Introductionmentioning

confidence: 99%

“…In the centromedial amygdala, this information is key to unraveling its functional anatomical organization in mammals and to establish the basis for comparisons with other species [Moreno et al, 2009;Medina et al, 2011;Abellán et al, 2013]. We expect that such studies applied to the basal ganglia and done in different species in the light of evolutionary developmental biology [Wullimann and Mueller, 2004;Medina, 2009;Moreno et al, 2009] will be essential in order to be able to: (a) identify the same molecularly distinct progenitor zones that produce neurons for the basal ganglia nuclei in different species 1 ; (b) know whether basal ganglia nuclei in different species, if present, are formed by identical or partially different sets of neuron subpopulations (identified by their embryonic origin and transcription factor expression during development), and (c) identify possible mechanisms that may explain the evolution of the basal ganglia (for example, changes in the expression of developmental regulatory genes, and in the enhancers, activators, repressors and/or cofactors that regulate the expression), taking into account that evolution of morphological diversity is the consequence of nonlethal changes that occurred during development and were preserved by natural selection [Carroll et al, 2001;Medina, 2007].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evolutionary and Developmental Contributions for Understanding the Organization of the Basal Ganglia

et al. 2014

Self Cite

View full text Add to dashboard Cite

Herein we take advantage of the evolutionary developmental biology approach in order to improve our understanding of both the functional organization and the evolution of the basal ganglia, with a particular focus on the globus pallidus. Therefore, we review data on the expression of developmental regulatory genes (that play key roles in patterning, regional specification and/or morphogenesis), gene function and fate mapping available in different vertebrate species, which are useful to (a) understand the embryonic origin and basic features of each neuron subtype of the basal ganglia (including neurotransmitter/neuropeptide expression and connectivity patterns); (b) identify the same (homologous) subpopulations in different species and the degree of variation or conservation throughout phylogeny, and (c) identify possible mechanisms that may explain the evolution of the basal ganglia. These data show that the globus pallidus of rodents contains two major subpopulations of GABAergic projection neurons: (1) neurons containing parvalbumin and neurotensin-related hexapetide (LANT6), with descending projections to the subthalamus and substantia nigra, which originate from progenitors expressing Nkx2.1, primarily located in the pallidal embryonic domain (medial ganglionic eminence), and (2) neurons containing preproenkephalin (and possibly calbindin), with ascending projections to the striatum, which appear to originate from progenitors expressing Islet1 in the striatal embryonic domain (lateral ganglionic eminence). Based on data on Nkx2.1, Islet1, LANT6 and proenkephalin, it appears that both cell types are also present in the globus pallidus/dorsal pallidum of chicken, frog and lungfish. In chicken, the globus pallidus also contains neurons expressing substance P (SP), perhaps originating in the striatal embryonic domain. In ray-finned and cartilaginous fishes, the pallidum contains at least the Nkx2.1 lineage cell population (likely representing the neurons containing LANT6). Based on the presence of neurons containing enkephalin or SP, it is possible that the pallidum of these animals also includes the Islet1 lineage cell subpopulation, and both neuron subtypes were likely present in the pallidum of the first jawed vertebrates. In contrast, lampreys (jawless fishes) appear to lack the pallidal embryonic domain and the Nkx2.1 lineage cell population that mainly characterize the pallidum in jawed vertebrates. In the absence of data in other jawless fishes, the ancestral condition in vertebrates remains to be elucidated. Perhaps, a major event in telencephalic evolution was the novel expression of Nkx2.1 in the subpallium, which has been related to Hedgehog expression and changes in the regulatory region of Nkx2.1.

show abstract

Pax6 expression highlights regional organization in the adult brain of lungfishes, the closest living relatives of land vertebrates

López

Morona

Moreno

et al. 2019

J of Comparative Neurology

View full text Add to dashboard Cite

The Pax6 gene encodes a regulatory transcription factor that is key in brain development. The molecular structure of Pax6, the roles it plays and its patterns of expression in the brain have been highly conserved during vertebrate evolution. As neurodevelopment proceeds, the Pax6 expression changes from the mitotic germinal zone in the ventricular zone to become distributed in cell groups in the adult brain. Studies in various vertebrates, from fish to mammals, found that the Pax6 expression is maintained in adults in most regions that express it during development. Specifically, in amphibians, Pax6 is widely expressed in the adult brain and its distribution pattern serves to highlight regional organization of the brain. In the present study, we analyzed the detailed distribution of Pax6 cells in the adult central nervous system of lungfishes, the closest living relatives of all tetrapods. Immunohistochemistry performed using double labeling techniques with several neuronal markers of known distribution patterns served to evaluate the actual location of Pax6 cells. Our results show that the Pax6 expression is maintained in the adult brain of lungfishes, in distinct regions of the telencephalon (pallium and subpallium), diencephalon, mesencephalon, hindbrain, spinal cord, and retina. The pattern of Pax6 expression is largely shared with amphibians and helps to understand the primitive condition that would have characterized the common ancestors to all sarcopterygians (lobe‐finned fishes and tetrapods), in which Pax6 would be needed to maintain specific entities of subpopulations of neurons.

show abstract

The Olfactory Amygdala in Amniotes: An Evo‐Devo Approach

Cited by 42 publications

References 140 publications

Embryonic Origin of the Islet1 and Pax6 Neurons of the Chicken Central Extended Amygdala Using Cell Migration Assays and Relation to Different Neuropeptide-Containing Cells

Embryonic Origin of the Islet1 and Pax6 Neurons of the Chicken Central Extended Amygdala Using Cell Migration Assays and Relation to Different Neuropeptide-Containing Cells

Evolutionary and Developmental Contributions for Understanding the Organization of the Basal Ganglia

Pax6 expression highlights regional organization in the adult brain of lungfishes, the closest living relatives of land vertebrates

Contact Info

Product

Resources

About