Hypothalamic regulation of the cardiovascular and respiratory systems: role of specific opiate receptors

Faden, Alan I.; Feuerstein, Giora

doi:10.1111/j.1476-5381.1983.tb10547.x

Cited by 50 publications

(13 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our prepara tion the excitatory effects of morphine at 40 °C on auricular automaticity were pre vented by the opioid antagonist naloxone. These results are in agreement with other authors [3,11], who described that tachycar dia induced by morphine could be reversed by naloxone. Therefore we have to take into account the possibility that our experimental temperature (40 °C) could induce changes in opioid receptor affinity.…”

Section: Discussionsupporting

confidence: 83%

Temperature-Dependent Effects of Morphine on the Isolated Right Atrium

Ruiz

1992

Pharmacology

View full text Add to dashboard Cite

The aim of the present study was to examine whether changes in temperature alter the effects of morphine on isolated right atria. Morphine dose-response curves at different temperatures (30, 37 or 40 °C) from right atria of the rat were obtained. The maximal negative chronotropic effect induced by morphine was 11 ± 3% at 37 °C and 20 ± 1 % at 30 °C. However, when the temperature was increased to 40 °C, morphine induced a positive chronotropic effect. The increase in auricular automaticity induced by morphine at 40 °C was antagonized in the presence of naloxone (5 × 10^–6 mol/l). These data demonstrated that: (1) hyperthermia modifies the effects of morphine on isolated right atria and (2) at 40 °C morphine induces a positive chronotropic effect by activation of opioid receptors.

show abstract

Section: Discussionsupporting

confidence: 83%

Temperature-Dependent Effects of Morphine on the Isolated Right Atrium

Ruiz

1992

Pharmacology

View full text Add to dashboard Cite

show abstract

“…There is strong evidence supporting the concept that endogenous and exogenous opioids, acting at various sites in the brain, play an important part in regulating cardiovascular, renal, respiratory and autonomic activities as well as other functions (Holaday, 1983). This contention is supported by: (i) the fact that opioid receptors are found in brain nuclei that are known to control haemodynamic, cardiovascular, respiratory and renal functions (Simantov et al, 1977;Atweh & Kuhar, 1983;Faden & Feuerstein, 1983); (ii) the demonstration that the central opioid system mediates the hypotensive effect of centrally-acting antihypertensive drugs like clonidine (Kunos et al, 1981;Pan & Gutkowska, 1988); and finally (iii) the observation that central administration of opioids has potent cardiovascular and renal consequences (Feuerstein & Faden, 1982;Hassen et al, 1982a,b). Recent studies from our laboratory have shown that centrally-acting morphine has a strong impact on renal functions (Gutkowska et al, 1993) and that these effects are mediated by ANF which was first discovered by de Bold in 1981 in mammalian atria (De Bold et al, 1981).…”

Section: Renal Effects Of a U-opioid Agonist Discussionmentioning

confidence: 98%

Renal effects of TAPP, a highly selective μ‐opioid agonist

Gutkowska

Schiller

1996

British J Pharmacology

View full text Add to dashboard Cite

The effect of i.v. administration of TAPP, a highly selective and exclusively peripherally‐acting μ‐opioid receptor agonist, on urine output, urinary sodium, potassium and cyclic GMP, and on plasma immunoreactive atrial natriuretic factor (IR‐ANF) levels was studied in conscious normally hydrated female rats (200–250 g). TAPP treatment produced a significant dose‐dependent increase of urine output and urinary sodium, potassium and cyclic GMP excretion during the first hour. The highest TAPP dose used (2.5 mg kg−1 body weight) elicited a 10 fold elevation of urine output from 0.23 ± 0.06 ml h−1 to 2.5 ± 0.3 ml h−1 (n = 18) accompanied by augmented sodium [from 17.0 ± 4.7 μEq h−1 to 79 ± 12.7 μEq h−1, n = 18 (P < 0.001)], potassium [from 9.5 ± 2.5 μEq h−1 to 39.4 ± 6.6 μEq h−1, n = 18 (P < 0.005)], and cyclic GMP excretion [from 191 ± 21 pmol h−1 to 1340 ± 322 pmol h−1, n = 18 (P < 0.001)]. Plasma IR‐ANF rose from 22 ± 4 pg ml−1 to 508 ± 22 pg ml−1 (n = 18) (P < 0.001) 5 min after administration of TAPP (2500 μg kg−1). TAPP lowered systemic blood pressure, also in a dose‐related manner, 1–5 min after injection. This decrease in blood pressure was transient and did not last more than 10 min. Pretreatment with the opioid antagonist naloxone (0.8 mg per rat) abolished the diuretic, natriuretic and kaliuretic effect of TAPP (250 μg kg−1): urine output dropped from 1.16 ± 0.15 ml h−1, n = 12, to the control value of 0.15 ± 0.06 ml h−1, n = 12 (P < 0.001), sodium excretion fell from 57.5 ± 11 μEq h−1, to 21.3 ± 8.5 μEq h−1, n = 12 (P < 0.001), and potassium excretion decreased from 45.4 ± 9.7 μEq h−1, n = 12, to 16.1 ± 7.0 μEq h−1, (P < 0.001). Pretreatment with anti‐ANF serum (0.4 ml) abolished the diuretic effect of TAPP: urine output diminished significantly from 1.93 ± 0.28 to 0.88 ± 0.29 ml h−1 (P < 0.01) (n = 6). The TAPP‐induced diuretic action, increased sodium/potassium excretion and elevated urinary cyclic GMP levels were also reversed by anti‐ANF antibodies. Since TAPP is totally unable to cross the blood‐brain barrier, the ensemble of these observations led to the conclusion that the diuretic, natriuretic, kaliuretic and hypotensive effects produced by this μ‐opioid agonist through interaction with peripheral μ‐opioid receptors occur via ANF release.

show abstract

“…Opiates are also known to modulate autonomic outflow by action at central sites (34,35). According to the central action of taurine, our previous studies showed that taurine supplementation could attenuate the cold stress-induced augmentation of noradrenergic activity in the hypothalamus as in the hearts of DOCA-salt hypertensive rats, which suggests the possible role of the hypothalamic noradrenergic system in the hypotensive action of taurine (16).…”

Section: Discussionmentioning

confidence: 99%

Hypotensive effect of taurine. Possible involvement of the sympathetic nervous system and endogenous opiates.

Fujita¹,

Sato²

1988

J. Clin. Invest.

View full text Add to dashboard Cite

We studied the role of diminished sympathetic nervous system (SNS) activity and endogenous opiate activation in the hypotensive action of taurine, a sulfur amino acid, in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Supplementation of taurine could prevent the development of DOCA-salt hypertension in rats, but failed to change blood pressure in vehicle-treated control rats. Cardiac NE turnover, which was determined from the rate of decline of tissue NE concentration after the administration of a-methyl-p-tyrosine, was markedly accelerated in DOCA-salt rats, but 1% taurine supplement restored it to normal. Moreover, naloxone (2 mg/kg), the specific opiate antagonist, increased blood pressure in taurine-treated DOCA-salt rats, restoring it to levels similar to those in the DOCA-salt rats. In contrast, taurine did not decrease cardiac NE turnover in the control rats, nor did naloxone increase blood pressure in the taurine-treated control rats. Moreover, supplementation of taurine increased both 8-endorphin-like immunoreactive material and taurine contents in the hypothalamus of DOCA-salt rats, whereas it did not increase c-endorphin in that of control rats despite increased taurine contents. Thus, taurine not only normalized the increased cardiac SNS activity but also elicited an opiate-mediated vasodepressor response only in DOCA-salt rats. It is suggested, therefore, that endogenous opiate activation, which is intimately related to SNS suppression, may contribute to the antihypertensive effect of taurine in sodium chloride hypertension.

show abstract

Hypothalamic regulation of the cardiovascular and respiratory systems: role of specific opiate receptors

Cited by 50 publications

References 27 publications

Temperature-Dependent Effects of Morphine on the Isolated Right Atrium

Temperature-Dependent Effects of Morphine on the Isolated Right Atrium

Renal effects of TAPP, a highly selective μ‐opioid agonist

Hypotensive effect of taurine. Possible involvement of the sympathetic nervous system and endogenous opiates.

Contact Info

Product

Resources

About