Hypothalamic-pituitary-adrenal axis response to stress in male DUI recidivists

Couture, Sophie; Brown, Thomas G.; Ouimet, Marie Claude; Gianoulakis, Christina; Tremblay, Jacques; Carbonneau, René

doi:10.1016/j.aap.2007.06.003

Cited by 22 publications

(29 citation statements)

References 58 publications

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“…Most molecular pathways affect behavior directly or indirectly, but the most influential molecules are regulatory molecules involved in hormonal and nervous systems. Previous studies have highlighted the fact that the associations of cortisol, as an endocrine system hormone and serotonin as a nervous system transmitter, with SS are still controversial (Couture et al, 2008;Croissant et al, 2008;Gerra et al, 1999;Netter et al, 1996;Rosenblitt et al, 2001;Ruegg et al, 1997;Tyrka et al, 2006Tyrka et al, , 2007White et al, 2006). In the present study, the positive correlation of serum serotonin concentrations and SS scores failed to reach a significant level.…”

Section: Discussioncontrasting

confidence: 83%

“…White et al (2006) found that the TAS subscale is negatively related to the cortisol response to D-amphetamine. These findings are supported by Couture et al (2008), in their study on HPA axis dysregulation and SS; Croissant et al (2008) findings concerning the association between SS and cortisol; and Rosenblitt et al (2001) results on the link between SS and cortisol in male subjects. In the field of novelty seeking, Tyrka et al (2006Tyrka et al ( , 2007 reported that novelty seeking is associated with plasma cortisol at baseline and during the Dex/CRH test.…”

Section: Discussionsupporting

confidence: 68%

“…However, when Rosenblitt et al (2001) examined the relationship between SS behaviors and cortisol in male and female college students, the results revealed a significant negative relationship between salivary cortisol and SS in men, but not in women. White et al (2006) suggested that the Thrill and Adventure Seeking (TAS) subscale of SSS is negatively related to the cortisol response to D-amphetamine, and finally, Couture et al (2008) reported that hypothalamic-pituitary-adrenal (HPA) axis dysregulation is positively associated with engagement in high-risk behaviors, including alcohol consumption, SS, and cigarette smoking. Croissant et al (2008) investigated the stress-response dampening effects of SS in the neuroendocrine domain of 86 healthy men and women.…”

Section: Introductionmentioning

confidence: 98%

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Relationship of serum serotonin and salivary cortisol with sensation seeking

Shabani

Dehghani

Hedayati

et al. 2011

International Journal of Psychophysiology

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Section: Discussioncontrasting

confidence: 83%

Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 98%

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Relationship of serum serotonin and salivary cortisol with sensation seeking

Shabani

Dehghani

Hedayati

et al. 2011

International Journal of Psychophysiology

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“…Similarly, others have noted that reduced HPA reactivity may be predictive of risk of relapse risk to smoking (al'Absi, 2006) and alcoholism (Adinoff, et al, 2005; Lovallo, 2006). Similarly, drunk driving recidivists show blunted cortisol responses to stress (Couture, et al, 2008). …”

Section: The Impact Of Adversity On Health and Psychological And Bmentioning

confidence: 99%

Early life adversity reduces stress reactivity and enhances impulsive behavior: Implications for health behaviors

Lovallo

2013

International Journal of Psychophysiology

276

226

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Altered reactivity to stress, either in the direction of exaggerated reactivity or diminished reactivity, may signal a dysregulation of systems intended to maintain homeostasis and a state of good health. Evidence has accumulated that diminished reactivity to psychosocial stress may signal poor health outcomes. One source of diminished cortisol and autonomic reactivity is the experience of adverse rearing during childhood and adolescence. The Oklahoma Family Health Patterns Project has examined a cohort of 426 healthy young adults with and without a family history of alcoholism. Regardless of family history, persons who had experienced high degrees of adversity prior to age 16 had a constellation of changes including reduced cortisol and heart rate reactivity, diminished cognitive capacity, and unstable regulation of affect, leading to behavioral impulsivity and antisocial tendencies. We present a model whereby this constellation of physiological, cognitive, and affective tendencies is consistent with altered central dopaminergic activity leading to changes in brain function that may foster impulsive and risky behaviors. These in turn may promote greater use of alcohol other drugs along with adopting poor health behaviors. This model provides a pathway from early life adversity to low stress reactivity that forms a basis for risky behaviors and poor health outcomes.

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“…10–13 Our research group extended these findings to the traffic-injury field by linking reduced cortisol response to stress to more severe and intractable impaired driving behavior in adults. 14,15 …”

mentioning

confidence: 99%

Higher Crash and Near-Crash Rates in Teenaged Drivers With Lower Cortisol Response

et al. 2014

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IMPORTANCE Road traffic crashes are one of the leading causes of injury and death among teenagers worldwide. Better understanding of the individual pathways to driving risk may lead to better-targeted intervention in this vulnerable group. OBJECTIVE To examine the relationship between cortisol, a neurobiological marker of stress regulation linked to risky behavior, and driving risk. DESIGN, SETTING, AND PARTICIPANTS The Naturalistic Teenage Driving Study was designed to continuously monitor the driving behavior of teenagers by instrumenting vehicles with kinematic sensors, cameras, and a global positioning system. During 2006–2008, a community sample of 42 newly licensed 16-year-old volunteer participants in the United States was recruited and driving behavior monitored. It was hypothesized in teenagers that higher cortisol response to stress is associated with (1) lower crash and near-crash (CNC) rates during their first 18 months of licensure and (2) faster reduction in CNC rates over time. MAIN OUTCOMES AND MEASURES Participants’ cortisol response during a stress-inducing task was assessed at baseline, followed by measurement of their involvement in CNCs and driving exposure during their first 18 months of licensure. Mixed-effect Poisson longitudinal regression models were used to examine the association between baseline cortisol response and CNC rates during the follow-up period. RESULTS Participants with a higher baseline cortisol response had lower CNC rates during the follow-up period (exponential of the regression coefficient, 0.93; 95%CI, 0.88–0.98) and faster decrease in CNC rates over time (exponential of the regression coefficient, 0.98; 95%, CI, 0.96–0.99). CONCLUSIONS AND RELEVANCE Cortisol is a neurobiological marker associated with teenaged-driving risk. As in other problem-behavior fields, identification of an objective marker of teenaged-driving risk promises the development of more personalized intervention approaches.

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Hypothalamic-pituitary-adrenal axis response to stress in male DUI recidivists

Cited by 22 publications

References 58 publications

Relationship of serum serotonin and salivary cortisol with sensation seeking

Relationship of serum serotonin and salivary cortisol with sensation seeking

Early life adversity reduces stress reactivity and enhances impulsive behavior: Implications for health behaviors

Higher Crash and Near-Crash Rates in Teenaged Drivers With Lower Cortisol Response

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