Hypothalamic-pituitary-adrenal axis function and cytokine production in multiple sclerosis with or without interferon-β treatment

“…Free radicalinduced lipid peroxidation is believed to play an important role in the pathogenesis of this secondary injury (4,5,24,25,26). But, as lipid peroxidation was demonstrated experimentally to reach peak values immediately after SCI, they appear to be unsuitable targets for pharmacological treatment of SCI in clinical practice (27). Thus, there is a clear and urgent need for a neuroprotective agent with proven effi cacy and minimal risk of side effects and toxicity.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of high-dose human albumin against traumatic spinal cord injury in rats

Yildirim¹,

Okutan²,

Akpınar³

et al. 2018

BLL

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BACKGROUND AND OBJECTIVES: Human serum albumin (HA) is a unique multifunctional protein with neuroprotective properties. We aimed to delineate the mechanisms of HA-induced neuroprotection, supresses infl ammatory response and lipid peroxidation after spinal cord injury (SCI). METHODS AND STUDY DESIGN: Adult female Wistar rats weighing 210-250 g were used for the study. The rats were randomly and blindly allocated into fi ve groups. The one-way analysis of variance (ANOVA) for parametric data and Shapiro-Wilk test was used for evaluating the normal distribution of the variables. Kruskal-Wallis for nonparametric data was used to compare groups. Electron and light microscopies were used to demonstrate ultrastructural changes in spinal cord. RESULTS: The HA group was signifi cantly different from all the other groups (p < 0.05). Both MPSS and HA treatments decreased the MPO signifi cantly. HA treatment decreased the lipid peroxidation. HA treatment prevented the worsening of clinical results. In the HA treatment group, the ultrastructure was protected signifi cantly. The neuronal bodies and axonal structures were normal except for some limited edematous spaces. CONCLUSIONS: HA improves early clinical results, protects spinal cord ultrastructure, and decreases MPO and LPO levels after spinal cord contusion injury (Tab. 3, Fig. 3, Ref. 39). Text in PDF www.elis.sk.

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“…Recently, Goebel et al (46) have shown that in patients with MS long-term treatment with IFN beta had no effect on activity of the hypothalamic-pituitary-adrenal (HPA) axis and did not alter the patients' mood states. In another study, IFN beta administered to patients with MS had no significant effect on HPA axis (47 …”

Section: Mood-related Symptomsmentioning

confidence: 93%

Neuropsychiatric Complications of Interferons: Classification, Neurochemical Bases, and Management

Malek-Ahmadi¹,

Hilsabeck²

2007

Annals of Clinical Psychiatry

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Hypothalamic-pituitary-adrenal axis function and cytokine production in multiple sclerosis with or without interferon-β treatment

Abstract: In MS the HPA axis function seems normal and not influenced by IFN-beta treatment. This result is discussed in relation to the increased production of pro-inflammatory cytokines found in this disease.

Cited by 21 publications

References 37 publications

The role of stress-response systems for the pathogenesis and progression of MS

The role of stress-response systems for the pathogenesis and progression of MS

Neuroprotective effects of high-dose human albumin against traumatic spinal cord injury in rats

Neuropsychiatric Complications of Interferons: Classification, Neurochemical Bases, and Management

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