Neuroprotective effects of high-dose human albumin against traumatic spinal cord injury in rats

Yildirim, Timur M.; Okutan, Özerk; Akpınar, Ersin; Yılmaz, Atilla; Işık, Hatice

doi:10.4149/bll_2018_016

Cited by 5 publications

(3 citation statements)

References 34 publications

(39 reference statements)

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“…Albumin's neuroprotective action has been reported in vitro in preventing neurotoxicity in hippocampal slice cultures (Dani et al, 2019) and DNA damage (Baltanas et al, 2009), zinc toxicity (Lin et al, 2005), oxidative stress (Gum et al, 2004), and intracellular calcium overload (Gallego-Sandin et al, 2005) in cultured neurons. Its beneficial effect has also been documented in vivo in rat (Park et al, 2017;Yildirim et al, 2018) and in humans (Palesch et al, 2006;Suarez et al, 2012). Interestingly, in a transgenic mouse model of Alzheimer's disease (Ezra et al, 2016), HSA-treated mice showed increased myelin integrity and myelin basic protein (MBP) protein level.…”

Section: Discussionmentioning

confidence: 97%

Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures

Monnerie,

Romer,

Roth

et al. 2023

Front. Mol. Neurosci.

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Combined antiretroviral therapy (cART) has greatly decreased mortality and morbidity among persons with HIV; however, neurologic impairments remain prevalent, in particular HIV-associated neurocognitive disorders (HANDs). White matter damage persists in cART-treated persons with HIV and may contribute to neurocognitive dysfunction as the lipid-rich myelin membrane of oligodendrocytes is essential for efficient nerve conduction. Because of the importance of lipids to proper myelination, we examined the regulation of lipid synthesis in oligodendrocyte cultures exposed to the integrase strand transfer inhibitor elvitegravir (EVG), which is administered to persons with HIV as part of their initial regimen. We show that protein levels of genes involved in the fatty acid pathway were reduced, which correlated with greatly diminished de novo levels of fatty acid synthesis. In addition, major regulators of cellular lipid metabolism, the sterol regulatory element-binding proteins (SREBP) 1 and 2, were strikingly altered following exposure to EVG. Impaired oligodendrocyte differentiation manifested as a marked reduction in mature oligodendrocytes. Interestingly, most of these deleterious effects could be prevented by adding serum albumin, a clinically approved neuroprotectant. These new findings, together with our previous study, strengthen the possibility that antiretroviral therapy, at least partially through lipid dysregulation, may contribute to the persistence of white matter changes observed in persons with HIV and that some antiretrovirals may be preferable as life-long therapy.

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Section: Discussionmentioning

confidence: 97%

Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures

Monnerie,

Romer,

Roth

et al. 2023

Front. Mol. Neurosci.

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“… 10 , 19 , 20 According to previous studies, albumin may exert neuroprotective function via its anti-inflammatory activity, antioxidant characteristics, inhibiting endothelial apoptosis, and regulating microvascular permeability. 21–23 Another theory is that low albumin in time of acute stroke could illustrate the role albumin’s concentration plays during inflammation states as a negative acute phase reactant. 24 Negative regulation of the albumin synthesis may be controlled via interleukin (IL-6 and tumor necrosis factor, which are seen in increased concentrations during states of acute inflammation, such as acute stroke.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil Albumin Ratio is Associated with All-Cause Mortality in Stroke Patients: A Retrospective Database Study

Xie¹,

Y²,

Dai³

et al. 2022

IJGM

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Objective: The novel biomarker, neutrophil percentage-to-albumin ratio (NPAR), as a prognostic tool for inflammation in relation to all-cause mortality for patients afflicted by strokes has yet to be explored. Methods: Data sets associated with patient files stored within the MIMIC-III V1.4 database were obtained. Data files from 940-patients were obtained for this retrospective analysis. Clinical endpoints were determined to represent a month (30-), three months (90-) and year (365-) all-cause mortality in stroke patients were determined. In order to determine NPAR and clinical endpoint relationships, Cox proportional hazards models were utilized. Results: For all-cause mortality within a 30-day period, in an unadjusted model, the HR (95% CIs) in group B (NPAR 20.5-25.0) and C (NPAR >25.0) was 1.17 (0.85, 1.63) and 1.55 (1.13, 2.11) compared with group A (NPAR < 20.5). Proceeding adjustment for more confounding factors, higher NPAR still obtained significant predictive power for 30-day allcause mortality (HR= 1.45, 95% CI: 1.05, 2.00). Statistical significance (P = 0.0196) was also observed for the other time-based subgroupings for all-cause mortality. Conclusion:A strong correlation was present between increased levels of the novel biomarker NPAR and increased risk of mortality in stroke patients.

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“…[19][20][21] This is why current studies on SCI treatment focus on secondary injury, and the antioxidant effects of neuroprotective agents play an important role in this area. [22][23][24] The negative results obtained from many clinical and experimental studies have shown that there is an urgent need for an effective, non-toxic neuroprotective agent with a low side effect profile in the treatment of SCI.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Annona muricata (graviola) in experimental spinal cord injury: biochemical and histopathological analysis

Keskin¹

2021

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Annona muricata (AM) (graviola) is a plant that grows in tropical regions and is thought to be good for many diseases by local people. Unfortunately, there is no acceptable medical treatment for spinal cord injury (SCI) yet. In our study, we investigated the neuropeotective effects of AM leaf extract on SCI in an experimental rat model. METHODS:A total of 40 Wistar albino rats were randomly divided into five equal groups (n=8). Group 1 was the control group in which only laminectomy was performed. Trauma was induced in four groups after laminectomy. Group 2 (untreated trauma group) was given no medication. In Group 3, a single intraperitoneal dose of methylprednisolone (30 mg/kg) was administered after trauma. The rats in Groups 4 received a low dose (100 mg/kg) of AM leaf extracts by oral gavage one week before trauma while the rats in Group 5 received a high-dose (300 mg/kg) of these extracts by oral gavage one week before trauma. All rats, including the control group, were sacrificed 24 h after the trauma was created.RESULTS: Tissue samples taken to evaluate the neuroprotective effect were examined biochemically and histopathologically. Inflammatory findings in the trauma group were significantly better in both groups treated with AM. There was no difference between the groups in terms of clinical motor examination and inclined plane test results. CONCLUSION:Our histopathological and biochemical results showed that AM is an agent with neuroprotective effects in traumatic SCI.

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Neuroprotective effects of high-dose human albumin against traumatic spinal cord injury in rats

Cited by 5 publications

References 34 publications

Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures

Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures

Neutrophil Albumin Ratio is Associated with All-Cause Mortality in Stroke Patients: A Retrospective Database Study

Efficacy of Annona muricata (graviola) in experimental spinal cord injury: biochemical and histopathological analysis

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