Hypotensive and diuretic activities of aqueous-ethanol extract of &lt;i&gt;Asphodelus tenuifolius&lt;/i&gt;

Aslam, Naveed; Janbaz, Khalid Hussain; Jabeen, Qaiser

doi:10.3329/bjp.v11i4.27131

Cited by 19 publications

(21 citation statements)

References 20 publications

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“…The high concentration of potassium High-K + (K-80mM) in the extracellular fluid may result in the opening of voltageoperated calcium channels and leads to the contraction of smooth muscles. The compounds which cause the relaxation of K-80mM induced contractions in smooth muscles are considered as calcium channel antagonists [24][25][26]. The results of the present study have shown that the spasmolytic activity of thiophene derivatives may be due to the blockage of calcium channels.…”

Section: Spasmolytic Activitymentioning

confidence: 63%

Design, synthesis, and spasmolytic activity of thiophene-based derivatives via Suzuki cross-coupling reaction of 5-bromothiophene-2-carboxylic acid: their structural and computational studies

Rasool¹,

Ikram²,

Rashid³

et al. 2020

Turk J Chem

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In the current research work, a facile synthesis of a series of novel thiophene-based derivatives of 5-bromothiophene-2- carboxylic acid (1) have been synthesized. All analogs (5a-5e, 10a-10f) were obtained from the coupling reaction of 5-bromothiophene- 2-carboxylic acid (1) and different arylboronic acids with moderate-to-good yields under controlled and optimal conditions. The structures of the newly synthesized compounds were characterized through spectral analysis and their spasmolytic activity, and most of the compounds exhibited potentially good spasmolytic effect. Among the synthesized analogs, compound phenethyl 5-(3,4-dichlorophenyl)thiophene-2-carboxylate (10d) particular showed an excellent spasmolytic effect with an EC50 value of 1.26. All of the compounds were also studied for their structural and electronic properties by density functional theory (DFT) calculations. Through detailed insight into frontier molecular orbitals of the compounds and their different reactivity descriptors, it was found that the compounds 10c and 5c are the most reactive, while 10a is the most stable in the series. Furthermore, compounds 10c and 5c showed a very good NLO response with the highest β values.

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Section: Spasmolytic Activitymentioning

confidence: 63%

Design, synthesis, and spasmolytic activity of thiophene-based derivatives via Suzuki cross-coupling reaction of 5-bromothiophene-2-carboxylic acid: their structural and computational studies

Rasool¹,

Ikram²,

Rashid³

et al. 2020

Turk J Chem

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“…The whole plant extract showed in vivo hypotensive and diuretic activity in normotensive rats [74]. The root extract of this species showed anti-oxidant activity (DPPH test, IC 50 = 2.006 µg/mL) [25] and asphorodin, a compound isolated from the whole plant extract, exhibit a potent inhibition of lipoxygenase enzyme, (IC 50 = 18.1 µM) [26], which may have an important role as an anti-inflammatory agent.…”

Section: Resultsmentioning

confidence: 99%

A Comprehensive Review on the Medicinal Plants from the Genus Asphodelus

Malmir

Serrano

Caniça

et al. 2018

Plants

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Plant-based systems continue to play an essential role in healthcare, and their use by different cultures has been extensively documented. Asphodelus L. (Asphodelaceae) is a genus of 18 species and of a total of 27 species, sub-species and varieties, distributed along the Mediterranean basin, and has been traditionally used for treating several diseases particularly associated with inflammatory and infectious skin disorders. The present study aimed to provide a general review of the available literature on ethnomedical, phytochemical, and biological data related to the genus Asphodelus as a potential source of new compounds with biological activity. Considering phytochemical studies, 1,8-dihydroxyanthracene derivatives, flavonoids, phenolic acids and triterpenoids were the main classes of compounds identified in roots, leaf and seeds which were correlated with their biological activities as anti-microbial, anti-fungal, anti-parasitic, cytotoxic, anti-inflammatory or antioxidant agents.

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“…The analysis of the literature shows that the extracts of the plant of the genus Asphodelus have been used and tested for the treatment of various pathologies, among which: Hypertension for its vasodilatory and diuretic effects, as reported by Aslam et al (2016) [19] on a study on mice reporting a vasodilator effect due to a mechanism similar to calcium channel blockers, and a diuretic effect similar to thiazides; for the treatment of gastric ulcer, Gürbüz et al (2002) shows a use of the root of Asphodelus eastivus with a gastro-protector effect [20]; Anand et al 2012 [21] and Sharma et al (2011) report a medical use, the first in Africa and the second in India, for the treatment of nephrolithiasis with an increase in diuresis [22].…”

Section: Discussionmentioning

confidence: 99%

Possible Uses of Plants of the Genus Asphodelus in Oral Medicine

et al. 2019

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Among the many plants used in traditional medicine we have the plants of the genus Asphodelus, which are present in the Mediterranean area in North Africa and South East Asia, and have been used by indigenous peoples until recently for various pathologies, including: Psoriasis, alopecia areata, acne, burns, nephrolithiasis, toothache, and local inflammation. The scientific literature over the last five years has investigated the various effects of the metabolites extracted from plants of the genus Asphodelus, paying attention to the diuretic, antihypertensive, antimicrobial, anti-inflammatory, and antioxidant effects, and it also has begun to investigate the antitumor properties on tumor cell lines. Studies have been identified through bibliographic research on electronic databases. A total of 574 records were identified on the PubMed, Scopus, Web of Science, and EBSCO databases. After having proceeded to the screening of the articles with the application of the eligibility criteria (all the articles pertaining to the issue Asphodelus), we arrived at a number of 163 articles, and then after the elimination of overlaps, to 82 articles. There are 11 articles which investigate the possible uses of plants of the genus Asphodelus in oral medicine. In oral medicine, the possible uses investigated by the scientific literature are for the treatment of neoplastic (melanoma and oral cancer), viral (herpetic viruses), and microbial diseases (candida, bacteriosis, leishmaniasis), and in the affection of the skin.

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Hypotensive and diuretic activities of aqueous-ethanol extract of <i>Asphodelus tenuifolius</i>

Cited by 19 publications

References 20 publications

Design, synthesis, and spasmolytic activity of thiophene-based derivatives via Suzuki cross-coupling reaction of 5-bromothiophene-2-carboxylic acid: their structural and computational studies

Design, synthesis, and spasmolytic activity of thiophene-based derivatives via Suzuki cross-coupling reaction of 5-bromothiophene-2-carboxylic acid: their structural and computational studies

A Comprehensive Review on the Medicinal Plants from the Genus Asphodelus

Possible Uses of Plants of the Genus Asphodelus in Oral Medicine

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