Possible Uses of Plants of the Genus Asphodelus in Oral Medicine

Abstract

Among the many plants used in traditional medicine we have the plants of the genus Asphodelus, which are present in the Mediterranean area in North Africa and South East Asia, and have been used by indigenous peoples until recently for various pathologies, including: Psoriasis, alopecia areata, acne, burns, nephrolithiasis, toothache, and local inflammation. The scientific literature over the last five years has investigated the various effects of the metabolites extracted from plants of the genus Asphodelus, paying attention to the diuretic, antihypertensive, antimicrobial, anti-inflammatory, and antioxidant effects, and it also has begun to investigate the antitumor properties on tumor cell lines. Studies have been identified through bibliographic research on electronic databases. A total of 574 records were identified on the PubMed, Scopus, Web of Science, and EBSCO databases. After having proceeded to the screening of the articles with the application of the eligibility criteria (all the articles pertaining to the issue Asphodelus), we arrived at a number of 163 articles, and then after the elimination of overlaps, to 82 articles. There are 11 articles which investigate the possible uses of plants of the genus Asphodelus in oral medicine. In oral medicine, the possible uses investigated by the scientific literature are for the treatment of neoplastic (melanoma and oral cancer), viral (herpetic viruses), and microbial diseases (candida, bacteriosis, leishmaniasis), and in the affection of the skin.

Therapeutic Anticancer Uses of the Active Principles of “Rhopalurus junceus” Venom

“…The study was conducted with reference to the guidelines described by the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) [ 5 ]. The materials and methods used in this review were also used in previous reviews of the same author’s literature [ 6 , 7 ]. The questions the authors ask are: “What are the effects of scorpion venom on cancer cell lines?” and, more generally, “What are the therapeutic potentials of the poison?” Considering these questions, the search for bibliographical sources was conducted.…”

“…The increase in p53 led to an upregulation of bax and caspase 3 and to a downregulation of bcl-2. The increase in the bax/bcl-2 ratio activated the mitochondrial pathway of apoptosis with the release of cytochrome c (Cyt c) and the activation of caspase cascades (3,6,7), which led to the proteolytic breakdown of important cytoplasmic and nuclear substrates [17].…”

Therapeutic Effect of Asphodelus Tenuifolius Against Streptozotocin Induced Diabetic Rats

“…For the purpose, out of numerous herbs used in common medicines, the subfamily of Asphodelus tenuifolius, that is native to the Mediterranean in North Africa and South East Asia, is recognized as Piazi in Urdu and Onion weed in English used newly for several ailments, Burns, Alopecia Areata, Psoriasis, Acne, Nephrolithiasis , Inflammation, Acne & Toothache. Further-Volume 6 | Issue 1 more, there are eighteen more types of Asphodelus species, with a wide variety of classes, and almost all are widely represent the family of Asphodelus Tenuifolius, Asphodelus Ramosus, Asphodelus Microcarpus, Asphodelus Fistulosus and Asphodelus Aestivus [4].…”