Hypophyso-Gonadal Function in the Cryptorchid Child: Differences Between Unilateral and Bilateral Cryptorchids

Cacciari, E; Cicognani, A; Pirazzoli, P; Zappulla, F; Tassoni, P; Bernardi, Filippo; Salardi, S

doi:10.1530/acta.0.0830182

Cited by 36 publications

(14 citation statements)

References 6 publications

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“…Cacciari et al (1976) have not found any significant abnormalities of response to LH-RH in unilateral cryptorchids. Laron et al (1975) have shown that unilateral operated cryptorchids with compensatory contralateral testicular hypertrophy have basal plasma FSH levels and LH and FSH response to LH-RH greater than controls.…”

Section: Lh-rh Test In Cryptorchidismmentioning

confidence: 63%

The Use of Luteinizing Hormone-Releasing Hormone in Pediatric Patients

Job¹,

Chaussain²,

Gamier³

1977

Horm Res

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Luteinizing hormone-releasing hormone (LH-RH), first synthetized in 1971; became soon available for clinical purposes and was immediately used as a diagnostic tool in children and adolescents as well as in adults. The first results of the LH-RH test in pediatrics were reported in 1972 and soon after discussed in meetings allowing comparison of the data from different groups. From this time, a great number of publications has been devoted to the diagnostic usefulness of LH-RH in the study of pubertal development and of pituitary-gonadal disorders in children and adolescents. Until recently, the therapeutic use of LH-RH has been restricted by the lack of availability of sufficient amounts, so that only few preliminary data have been reported in this field. Thus the scope of this review is mainly to present a critical survey of the data concerning LH-RH test in pediatric patients.

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Section: Lh-rh Test In Cryptorchidismmentioning

confidence: 63%

The Use of Luteinizing Hormone-Releasing Hormone in Pediatric Patients

Job¹,

Chaussain²,

Gamier³

1977

Horm Res

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“…Illig et al [10] with a treatment schedule similar to Happ's method, carried out for four weeks, obtained complete descent of testes in 38% of cases. Conventional therapy with hCG has been described as reaching positive results varying from 200/0-90% [4].…”

Section: Discussionmentioning

confidence: 99%

“…c-id ,4o ,,6 r 4,~ +1 +1 +l +l t"q ~ t'-I +l +/ +l +l [4,12]. Immediately before the first insufflation and, then, every 30 rain for 4 h a sample was taken for the assay of FSH and LH (LH-RH spray test).…”

Section: +1 +L +1mentioning

confidence: 99%

Treatment of cryptorchidism by intranasal synthetic LH-RH and its analogue d-ser(TBU)6-LHRH-EA10

1982

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Abstract. Sixty-seven prepubertal boys with either uni-or bilateral cryptorchidism were treated with LH-RH or its analogue Hoe 766. In all cases the undescended testes were located in the inguinal canal; none had retractile testes.A) 23 boys were given 200 lag LH-RH-6 times daily for 7 days B) 24 boys were given 5001ag LH-RH-2 times daily for 7 days C) 10 boys received 100lag Hoe 766 every other day at 8 p.m.for a totaI of 8 insuffiations D) 10 boys received 25lag Hoe 766 every other day at 8 p.m.for a total of 8 insuffiations.The treatment was performed with control by LH-RH tests and testing the pituitary reserve of gonadotropins. Plasma testosterone was measured by RIA. Of the 47 boys treated with synthetic LH-RH, 14 (29.8%) gave a positive response with descent of the testes into the scrotum (A: 21.7%; B: 37.5%). The basal values and the pituitary reserves of LH and FSH did not change after therapy. Plasma testosterone showed an increase in the whole group of patients. Hoe 766 caused an increase in the FSH in all boys, but the curve was significantly higher in group C. There was no difference in plasma testosterone level between group C and D.None of the ten patients in group C responded to the therapy. In three patients of group D (30%) both testes descended. The administration of hCG to those boys who had not responded to the synthetic LH-RH or its analogue therapy led to the descent of three testes in group A and B, of two testes in group C, and of three testes in group D.Treatment of cryptorchidism by synthetic LH-RH or its analogue Hoe 766 for a short time can produce good results. The dosage of the drugs plays an important role in determining its effect.No change was found in gonadotropin secretion induced by synthetic LH-RH nasal spray therapy. The effect of intranasal administration of Hoe 766 is dose-dependent for FSH, but not for LH. When using synthetic LH-RH the best results were obtained by other authors with treatment of at least four weeks. The best results with synthetic or analogue LH-RH treatment were obtained in those subjects whose testes were located closer to the external ring. No side effects were observed either during or after the treatment.

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“…Patients with Klinefelter's syndrome, when diagnosed before the onset of puberty, have usually normal re sponses to LH-RH [9], In cryptorchid prepubertal boys, a significant decrease of LH response to LH-RH has been found, while their FSH response was normal [10]. How ever, these data do not agree completely with those found in other clinics [11,12], The administration of HCG induced about a 7-fold increase in testosterone in normal prepubertal boys [13]. Before the age of 12 years, the peak plasma testosterone response to HCG stimulation was within the normal range in Klinefelter's syndrome [9].…”

Section: Discussionmentioning

confidence: 79%