Hypopharyngeal and laryngeal involvement with Darier disease

Dellon, A. L.

doi:10.1001/archderm.111.6.744

Cited by 6 publications

(5 citation statements)

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“…Esophageal mucous membrane involvement in Darier's disease has been reported recently by Shimizu et al ., 19 who reported a case of Darier's disease and esophageal carcinoma. In their report, they noticed esophageal involvement pathologically when they examined the postoperative specimens of the esophageal carcinoma.…”

Section: Discussionmentioning

confidence: 65%

“…The mucosal lesions in Darier's disease are uncommon and their incidence varies in different studies, ranging from 15% to 50% 3,4,10,12 . Most of the studies that have evaluated the mucosal involvement in Darier's disease concentrated on oral mucosa lesions, however, rectal mucosal involvement, 15 localized disease to the vulva, 16,17 salivary glands obstruction, 18 and hypopharyngeal and laryngeal involvement 19 have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Dellon et al 19 . evaluated four patients with Darier's disease for the possibility of hypopharyngeal and laryngeal mucous membrane involvement in the disease processes.…”

Section: Discussionmentioning

confidence: 99%

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Extensive Darier's disease with esophageal Involvement

et al. 2004

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Although the involvement of mucous membranes in Darier's disease is relatively uncommon, Darier's disease has been associated with mucosal lesions, especially in the oral mucosa. In the English literature there is only one report describing the involvement of esophageal mucous membranes in a patient with Darier's disease. Herein, we report the second case of Darier's disease with esophageal involvement.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

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Extensive Darier's disease with esophageal Involvement

et al. 2004

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“…It is characterized by scal ing brownish papules of the skin, mainly on the scalp, the forehead, the back and in intertriginous regions. The mu cous membranes of the mouth, larynx and pharynx are rare ly affected [5], The histological changes of the skin are: su perficial and follicular hyperkeratosis, parakeratosis, acan thosis and a characteristic proliferation of basal cells in double rows. Suprabasal lacunae with peculiar villous for mations develop by acantholysis.…”

Section: Discussionmentioning

confidence: 99%

Ocular Involvement in Keratosis Follicularis Associated with Retinitis Pigmentosa

Daicker

1995

Ophthalmologica

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In 1988, Itin et al. published the combination of keratosis follicularis (KF; Darier-White disease), an autosomal-dominantly transmitted genodermatosis, and retinitis pigmentosa (RP) in two brothers. One of these patients died unexpectedly at the age of 54 years. His eyelids and globes were histologically studied post mortem. Involvement of the eyelids has rarely been described clinically and not at all histologically. The skin and the intermarginal zone of the lids exhibited the typical changes of this cutaneous disease involving the follicles of the eyelashes. Focal keratinizations of the limbal conjunctiva, a regional increase in conjunctival goblet cells and a diffuse thickening of the basement membrane of the corneal epithelium were present. They are probably not specific for KF. The retinal findings were those of a typical late stage of RP. The combination of both genetically transmitted disorders could point to a damage in neighbouring gene loci. An abnormality of the metabolism of vitamin A was supposed to play a pathogenetic role in both diseases but remains speculative, as does a genetic linkage.

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“…The finding of two patients with Darier's disease and cutaneous malignancies is of interest for several reasons. There have been no previous reports that patients with Darier's disease have an increased incidence of malignancy, although there have been occasional reports of association with benign cutaneous neoplasms 1,2 and laryngeal lesions that are said to have resembled malignancy 3 …”

Section: Commentmentioning

confidence: 99%