Hyponatremic Seizures After Polyethylene Glycol Bowel Preparation: The Elderly at Risk

Saradna, Arjun; Shankar, Shyam; Soni, Parita; Pendkar, Chetana; Saxena, Abhinav; Kupfer, Yizhak; Kamholz, Stephan L.

doi:10.1097/mjt.0000000000000789

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…Some of the predisposing risk factors for the development of cerebral edema and neurological complications due to acute hyponatremia are old age, female gender, thiazide diuretics, selective serotonin reuptake inhibitor (SSRI) antidepressants, premenopausal women after surgery, children, psychogenic polydipsia, and hypoxia. 6,7 Polyethylene glycol is a biologically inactive isoosmotic laxative that binds to water and keeps water inside the lumen of gastrointestinal tract. 8,9 It usually does not cause any electrolyte abnormalities.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hyponatremia‐induced generalized seizure after taking polyethylene glycol for colon preparation—A case report and brief review of the literature

Seirafian

Sebghatollahi

Bastani

2022

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hyponatremia‐induced generalized seizure after taking polyethylene glycol for colon preparation—A case report and brief review of the literature

Seirafian

Sebghatollahi

Bastani

2022

Clinical Case Reports

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“…• Diarrhea leading to dehydration especially if water intake is minimal, can result in confusion and potentially seizures [22].…”

Section: Toxicity/overdosementioning

confidence: 99%

Perspective Chapter: Polyethylene Glycol Use in Colonoscopy Preparation Versus Chronic Constipation

Saleem

2024

Polyethylene - New Developments and Applications

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Polyethylene glycol is a product with many pharmaceutical and industrial uses due to its hydrophilic nature. As a medication, it is part of a laxative class of drugs which is minimally absorbed in gastrointestinal tract increasing osmotic pressure resulting in softening of stools and increased bowel movements. There are certain FDA and non FDA-approved indications for its use. Its main use is for the treatment of constipation, fecal impaction, chronic constipation, and colonoscopy preparation. Its administration is elaborated according to different age groups and indications. Polyethylene glycol is over-the-counter medication as there is easy access to this drug, but as a health care provider, we need to emphasize the directions for its appropriate use with proper counseling regarding the onset of action as well as when to discontinue it which will yield improved patient results while minimizing adverse events.

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Symptomatic Hyponatremia following Bowel Preparation for Colonoscopy: A Case Report

Shrestha

Acharya

Karki³

et al. 2020

J Nepal Med Assoc

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Colonoscopy is considered a gold standard tool for the diagnostic evaluation of colorectal diseases. Bowel preparation, a pre-requisite for colonoscopy, usually involves ingestion of purgatives for the cleansing of the bowel so that visualization is not obscured during the procedure. Commonly used preparations are sodium phosphate-based solutions, sodium picosulphate and polyethylene glycol. The use of such preparations is associated with electrolyte disturbances, commonly hyponatremia. Hyponatremia is usually seen with sodium phosphate based solutions and is rare with polyethylene glycol. Symptomatic hyponatremia, however, is rare following bowel preparation and is attributable to other factors as well, such as the age of patient, non-osmotic release of antidiuretic hormone and the procedure itself. In this report, we discuss a case of severe symptomatic hyponatremia observed in a 71-year-old gentleman who underwent polyethylene glycol based bowel preparation for colonoscopy.

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Hyponatremic Seizures After Polyethylene Glycol Bowel Preparation: The Elderly at Risk

Cited by 3 publications

References 5 publications

Hyponatremia‐induced generalized seizure after taking polyethylene glycol for colon preparation—A case report and brief review of the literature

Hyponatremia‐induced generalized seizure after taking polyethylene glycol for colon preparation—A case report and brief review of the literature

Perspective Chapter: Polyethylene Glycol Use in Colonoscopy Preparation Versus Chronic Constipation

Symptomatic Hyponatremia following Bowel Preparation for Colonoscopy: A Case Report

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