Hyponatremia‐induced generalized seizure after taking polyethylene glycol for colon preparation—A case report and brief review of the literature

Seirafian, Shiva; Sebghatollahi, Vahid; Bastani, Bahar

doi:10.1002/ccr3.6247

Cited by 2 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High-quality bowel cleansing is a prerequisite for colonoscopy. Polyethylene glycol (PEG)-based solution is the most widely used intestinal cleansing agent, although several cases have been reported to cause hyponatremia[ 2 - 4 ], it is a relatively safe option for patients at risk of electrolyte imbalance and dehydration[ 5 ]. As the most common electrolyte abnormality, hyponatremia is closely related to the brain.…”

Section: Introductionmentioning

confidence: 99%

Hyponatremic encephalopathy due to polyethylene glycol-based bowel preparation for colonoscopy: A case report

Zhao¹,

Dong²

2023

World J Clin Cases

View full text Add to dashboard Cite

BACKGROUND Adequate bowel preparation is critical for colonoscopy screening. At present, the most widely used intestinal cleaner recommended at home and abroad is Polyethylene glycol (PEG). Intestinal cleansers can cause electrolyte disturbances and hyponatremia. However, hyponatremic encephalopathy due to hyponatremia induced by PEG solution, although rare, can lead to serious irreversible sequelae and even death. CASE SUMMARY In this report, we discuss a case of neurological dysfunction due to hyponatremia, also known as hyponatremic encephalopathy, observed in a 63-year-old woman who underwent PEG-based bowel preparation for colonoscopy. She was eventually transferred to our intensive care unit for treatment due to her Glasgow Coma Scale score of 9/15 (Eye opening 2; Verbal response 1; Motor response 6) and abnormal laboratory tests. CONCLUSION Physicians should be thoroughly familiarized with the patient's history before prescribing PEG for bowel preparation, and timely identification of patients with hyponatremic encephalopathy is essential as delayed treatment is associated with poor neurological outcomes. An intravenous infusion of 3% sodium chloride is recommended at the onset of early symptoms. The goal of treatment is to adequately treat cerebral edema while avoiding serum sodium correction beyond 15 to 20 mEq/L within 48 h of treatment to prevent osmotic demyelination syndrome.

show abstract

Section: Introductionmentioning

confidence: 99%