Hyponatremia predicts mortality after stroke

Abstract

Hyponatremia is prevalent in acute stroke admissions and is independently associated with higher mortality in patients <75 years.

Addition of sodium criterion to SOAR stroke score

“…16 In comparison to preceding literature, the models utilized to predict mortality outcomes had a much smaller degree of adjustment. Although Soiza et al 15 also showed this association, this was lost when serum urea, another measure of dehydration, was controlled for along with other haematological and biochemistry variables. Considerably fewer variables were therefore controlled for.…”

“…Our findings support previously observed associations between dysnatremia and early mortality in stroke. [13][14][15] A U-shaped relationship is present with severe and moderate hyponatremia and hypernatraemia showing statistical significance once other variables relevant to the SOAR stroke score were adjusted for. Increased odds of mortality displayed in those with hyponatremia may be attributed to osmotic changes causing cerebral oedema and increased intracranial pressure leading to a subsequent increase in cell dysfunction and death.…”

“…15 Hypernatraemia has also been associated with early neurological worsening. [13][14][15] The aim of the models used within this study was to establish if sodium levels perform independently of the variables used within the SOAR stroke score. [13][14][15] The aim of the models used within this study was to establish if sodium levels perform independently of the variables used within the SOAR stroke score.…”

“…10 Indeed, both hypoand hypernatraemia have been shown to increase inpatient mortality in various settings including intensive care units and emergency departments. [13][14][15] We hypothesize that the addition of sodium levels would improve the performance of SOAR stroke score. [13][14][15] We hypothesize that the addition of sodium levels would improve the performance of SOAR stroke score.…”

“…[10][11][12] Recently, studies have established that hyponatremia increases both short-and long-term mortality in stroke patients. [13][14][15] We hypothesize that the addition of sodium levels would improve the performance of SOAR stroke score.…”