Hyponatraemia and neurological complications in children admitted with bronchiolitis

Shibli, Amar Al; Abukhater, Dima; Kuwaiti, Najla Al; Noureddin, Muhammad Bassel; Harbi, Mariam Al; Kaabi, Aysha Al; Kaabi, Salwa Al; Hamie, May; Amri, Abdulla Al; Narchi, Hassib

doi:10.1080/20469047.2016.1162390

Cited by 13 publications

(19 citation statements)

References 19 publications

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“…Hypotonic hyponatremia often (≥20%) occurs among children with lower respiratory tract infections such as bronchiolitis and community acquired pneumonia . Hyponatremia is associated with a severe disease, a long hospital stay and increased mortality.…”

Section: Prevalencementioning

confidence: 99%

“…Severe symptoms include seizures, severely reduced (Pediatric) Glasgow Coma Scale, or Ayus‐Arieff pulmonary edema (vide infra). Nausea, vomiting, transient cessation of respiration, altered Glasgow Coma Scale, and seizures have been repeatedly observed in hyponatremic infants with bronchiolitis . Hyponatremic seizures, however, are uncommon in children with community acquired pneumonia .…”

Section: Consequences Of Hyponatremiamentioning

confidence: 99%

“…Nausea, vomiting, transient cessation of respiration, altered Glasgow Coma Scale, and seizures have been repeatedly observed in hyponatremic infants with bronchiolitis. [3][4][5][6][7] Hyponatremic seizures, however, are uncommon in children with community acquired pneumonia. [6][7][8][9] Bronchiolitis is sometimes associated with episodes of cessation of breathing.…”

Section: Consequences Of Hyponatremiamentioning

confidence: 99%

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Hyponatremia in children with acute respiratory infections: A reappraisal

Lavagno

Milani

Uestuener

et al. 2017

Pediatric Pulmonology

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Hyponatremia (<135 mmol/L), typically associated with an elevated anti-diuretic hormone level, is common among children admitted with bronchiolitis, pneumonia, or pulmonary exacerbation of cystic fibrosis. The main consequences of acute hyponatremia include cerebral edema and Ayus-Arieff pulmonary edema. A widespread belief is that, in children with pneumonia or bronchiolitis, hyponatremia results from inappropriate anti-diuresis. By contrast, the pathogenic role of extracellular fluid volume depletion or decreased effective circulating blood volume is underscored. Considering the prevalence of hyponatremia, sodium determination is advised on admission in children diagnosed with bronchiolitis, pneumonia, or pulmonary exacerbation of cystic fibrosis. There is no necessity to do anything beyond reassessing the appropriateness of fluid therapy in cases with mild (130-134 mmol/L) hyponatremia. In children with sodium <130 mmol/L, the underlying etiology is sometimes evident from history and physical findings. Given that clinical assessment of fluid volume status is difficult in hyponatremia, further laboratory evaluation is often required in these patients. An increase in sodium level ≤6 mmol/L per day is currently considered the therapeutic goal in all cases. Emergency correction with a 2 mL/kg body weight bolus of 3.0% saline over 10-15 min intravenously is advised in cases with severe symptoms due to hyponatremia and in cases with symptoms, even if mild, due to a rapid-onset (<48 h) of hyponatremia (two additional doses are administered if the patient's condition does not improve).

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Section: Prevalencementioning

confidence: 99%

Section: Consequences Of Hyponatremiamentioning

confidence: 99%

Section: Consequences Of Hyponatremiamentioning

confidence: 99%

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Hyponatremia in children with acute respiratory infections: A reappraisal

Lavagno

Milani

Uestuener

et al. 2017

Pediatric Pulmonology

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“…Îñîáëèâî ó íåìîâëÿò, îðãàí³÷í³ îñìîë³, ÿê³ àäàïòóþòü êë³òèíó äî õðîí³÷íî¿ ã³ïåðíàòð³åì³¿, äóaeå ïîâ³ëüíî âòðà÷àþòüñÿ êë³òèíàìè ïðè íîðìà-ë³çàö³¿ îñìîëÿðíîñò³ ³íòåðñòèö³þ. Ñàìå òîìó, øâèäêà ðåã³äðàòàö³ÿ, ÿêà ïðèçâîäèòü äî øâèäêî¿ êîðåêö³¿ õðîí³÷íî¿ ã³ïåðíàòð³åì³¿, âèêëèêàº â íèõ ñóäîìè òà âèïóêë³ñòü âåëèêîãî äaeåðåëüöÿ (ïðîÿâè íàáðÿêó ìîçêó) [32,33].…”

Section: êëàñèô²êàö²ß ã²ïîíàòð²åì²2unclassified

Hyponatremia: Causes, Clinical Manifestations and Correction

Фесенко¹

2019

Pain Anaesth Int Care

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Ðåçþìå: Ïðåäñòàâëåíèé àíàë³ç ë³òåðàòóðíèõ äaeåðåë ç ïðîáëåìè ã³ïîíàòð³åì³¿. Îïèñàí³ ïðè÷èíí³ ôàêòîðè, êë³í³÷í³ ïðîÿâè, êðèòåð³¿ òÿaeêîñò³ ã³ïîíàòð³åì³¿. Íàâåäåí³ ä³àãíîñòè÷í³ àëãîðèòìè äëÿ âèÿâëåííÿ ïðè÷èíè ã³ïîíàòð³åì³¿ íà ãðóíò³ îñìîëÿðíîñò³ ïëàçìè, âîëåì³÷íîãî ñòàòóñó ïàö³ºíòà òà ôðàêö³éíî¿ åêñêðåö³¿ íàòð³þ òà óðàò³â. Ïðîâåäåíèé àíàë³ç ñó÷àñíèõ ãàéäëàéí³â ç êîðåêö³¿ ã³ïîíàòð³åì³¿, îïèñàí³ ïîêàçè òà îáìåaeåííÿ çàñòîñóâàííÿ âàïòàí³â. Êëþ÷îâ³ ñëîâà: ã³ïîíàòð³åì³ÿ, âàçîïðåñèí, ñèíäðîì íåâ³äïîâ³äíî¿ ñåêðåö³¿ àíòèä³óðåòè÷íîãî ãîðìîíó, ñèíäðîì âòðàòè ñîëåé, âàïòàíè.

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“…15,[17][18][19][20][21][22] In patients with bronchiolitis, hyponatremia near the time of hospital admission is associated with unfavorable clinical outcomes, including increased need for mechanical ventilation, prolonged ICU length of stay (LOS), and increased mortality. 15,[22][23][24][25] It is not established if hyponatremia later in the course of bronchiolitis is similarly associated with unfavorable outcomes. Delayed hyponatremia may be a modifiable risk factor for severe disease, especially because some experts still recommend the use of hypotonic IVF and many practitioners report using them for infants with acute respiratory tract infections.…”

mentioning

confidence: 99%