Hypomagnesemia in Patients in Postoperative Intensive Care

Chernow, Bart; Bamberger, Stephan; Stoiko, Michael; Vadnais, Mary; Mills, Susan; Hoellerich, Vincent L.; Warshaw, Andrew L.

doi:10.1378/chest.95.2.391

Cited by 229 publications

(161 citation statements)

References 40 publications

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“…Elderly patients, especially those with CAD and heart failure, can have low body magnesium levels, and the mechanisms responsible for this are likely multifactorial. Although 37% of patients with congestive heart failure who receive diuretic therapy with the loop and thiazide diuretics have hypomagnesemia, 30 only 5 patients (14%) in the present study were receiving loop diuretics. Evidence suggests that the occidental "American diet" is relatively deficient in magnesium, whereas the "Oriental diet," which is characterized by a greater intake of fruits and vegetables, is rich in magnesium.…”

Section: Shechter Et Al Magnesium Improves Endothelial Functioncontrasting

confidence: 60%

Oral Magnesium Therapy Improves Endothelial Function in Patients With Coronary Artery Disease

et al. 2000

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Background-Magnesium blocks many of the physiological actions of calcium. Nevertheless, the impact of magnesium supplementation on endothelial function and exercise tolerance in stable coronary artery disease (CAD) patients has not been assessed. Methods and Results-In a randomized, double-blind, placebo-controlled trial, 50 stable CAD patients (41 men and 9 women, meanϮSD age 67Ϯ11 years, age range 42 to 82 years) were randomized to receive either magnesium (nϭ25) (30 mmol/d Magnosolv-Granulat; Asta Medica Company, Inc) or placebo (nϭ25) for 6 months. Before and after 6 months, endotheliumdependent brachial artery flow-mediated vasodilation (FMD) and endothelium-independent NTG-mediated vasodilation were assessed with high-resolution (10-MHz) ultrasound. Exercise stress testing was performed with use of the Bruce protocol. Intracellular magnesium concentrations ([Mg

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Section: Shechter Et Al Magnesium Improves Endothelial Functioncontrasting

confidence: 60%

Oral Magnesium Therapy Improves Endothelial Function in Patients With Coronary Artery Disease

et al. 2000

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“…One of the causes for this decrease is probably the large loss of fluid and fluid movement between different body compartments which occurs in these patients. These losses are normally A decrease in magnesium levels, especially below the considered lower normal limit of 0.7 mmol .l-', may be associated with a degree of muscle weakness [4] and an increased mortality [6]. Many of these patients may be admitted to an ITU or HDU in the postoperative period and may require ventilatory support.…”

Section: Discussionmentioning

confidence: 99%

“…Recent research has shown that magnesium is commonly depleted in critically-ill patients [3,4], especially if prolonged intensive care support is required, and also in the postoperative period after major surgery [5,6]. If magnesium depletion occurs, its negative influence on muscle function may make the process of weaning the patient from ventilatory support more prolonged [A. Hypomagnesaemia, when present in acutely ill medical patients on postoperative patients in 'the intensive care unit, is associated with an increase in mortality [6,8].…”

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confidence: 99%

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Peri‐operative effect of major gastrointestinal surgery on serum magnesium

Sanchez-Capuchino

McConachie

1994

Anaesthesia

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SummaryThis study investigates the changes in serum magnesium levels after major gastrointestinal surgery and evaluates if Plasma -Lyte 148 used as maintenance fluid influences these changes in the peri-operative period. Thirty patients presenting for procedures ranging from anterior rectal resection to thoraco -abdominal cardio -0esophagectomy were randomly allocated into two groups, one of which received compound sodium lactate solution as the maintenance crystalloid during the intra-and postoperative period, and the other Plasma-Lyte 148, a magnesium -containing crystalloid solution. Serum magnesium levels were measured pre-operatively, in the immediate recovery period and 24 h postoperatively. The results showed a statistically signiJicant ( p < 0.05) reduction in the magnesium levels in both groups. The reduction was less marked in the Plasma-Lyte group but this did not achieve statistical significance ( p > 0.05) compared with the compound sodium lactate group.

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“…Patients are considered frank hypomagnesaemic with serum Mg concentrations ≤0.61mmol/L or 1.5mg/dL [7][8][9]. Mg concentrations ≤0.75mmol/L or 1.8mg/dL may be considered a preclinical hypomagnesaemia [10,11].…”

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confidence: 99%

Magnesium and Type 2 Diabetes: An Update

Barbagallo¹

2015

Int J Diabetes Clin Res

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The link between magnesium (Mg) deficiency and type 2 diabetes mellitus is well known. Type 2 diabetes is frequently associated with both extracellular and intracellular Mg deficits. A chronic latent Mg deficit or an overt clinical hypomagnesaemia is common in subjects with type 2 diabetes, especially in those with poorly controlled glycemic profiles. Insulin and glucose are important regulators of Mg metabolism. Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose-uptake and vascular tone. Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, postreceptorial impairment in insulin action and worsening of insulin resistance in diabetic patients. A low Mg intake and an increased Mg urinary loss appear the most important mechanisms that may favor Mg depletion in patients with type 2 diabetes. Low dietary Mg intake has been related to the development of type 2 diabetes and metabolic syndrome. Benefits of Mg supplementation on metabolic profile in diabetic subjects have been found in most, but not all clinical studies and larger prospective studies are needed to support the potential role of dietary Mg supplementation as a possible public health strategy in diabetes risk.The objective of this review is to revise current evidences on the mechanisms of Mg deficiency in diabetes mellitus type 2 and on the possible role of Mg supplementation in the prevention and management of the disease.

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Hypomagnesemia in Patients in Postoperative Intensive Care

Cited by 229 publications

References 40 publications

Oral Magnesium Therapy Improves Endothelial Function in Patients With Coronary Artery Disease

Oral Magnesium Therapy Improves Endothelial Function in Patients With Coronary Artery Disease

Peri‐operative effect of major gastrointestinal surgery on serum magnesium

Magnesium and Type 2 Diabetes: An Update

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