Peri‐operative effect of major gastrointestinal surgery on serum magnesium

Abstract

SummaryThis study investigates the changes in serum magnesium levels after major gastrointestinal surgery and evaluates if Plasma -Lyte 148 used as maintenance fluid influences these changes in the peri-operative period. Thirty patients presenting for procedures ranging from anterior rectal resection to thoraco -abdominal cardio -0esophagectomy were randomly allocated into two groups, one of which received compound sodium lactate solution as the maintenance crystalloid during the intra-and postoperative period, and the other Plasma-Lyte 148, a magnesium -containing crystalloid solution. Serum magnesium levels were measured pre-operatively, in the immediate recovery period and 24 h postoperatively. The results showed a statistically signiJicant ( p < 0.05) reduction in the magnesium levels in both groups. The reduction was less marked in the Plasma-Lyte group but this did not achieve statistical significance ( p > 0.05) compared with the compound sodium lactate group.

Magnesium Can Decrease Postoperative Physiological Ileus and Postoperative Pain in Major non Laparoscopic Gastrointestinal Surgeries: A Randomized Controlled Trial

“…The control group received saline instead of up to 4 hours after the operation; the patients were assessed for pain during and after the operation, and received fentanyl. The results of the group who had received magnesium intra operative and postoperative, a significant (18) study introduced the decreasing effects of major gastrointestinal laparotomy on peri-operative serum level of magnesium (18). Physiologically obstruction (ileus) occurs as a complication of gastrointestinal surgery due to excessive intestinal manipulation, electrolyte imbalance (14), and receiving systemic opioids (19).…”

The effects of surgery and anesthesia on blood magnesium and calcium concentrations in canine and feline patients

“…In a human study of ionized hypomagnesmia following major gastrointestinal surgery, two groups were utilized, one receiving compound sodium lactate (4 mEq Ca 2+ L −1 ), and the other receiving Plasma‐lyte 148 (3 mEq Mg 2+ L −1 ). The choice of IV fluids did not significantly influence the hypomagnesemia that developed, although the authors thought that the degree of hypomagnesemia was less in the group that received Plasma‐lyte 148 (Sanchez‐Capuchino & McConachie 1994). Our infusion of fluids containing magnesium may have resulted in the mild increase in iMg that was seen.…”

“…Serum concentrations of magnesium and calcium have been reported to decrease during anesthesia. Although this occurs most predictably in humans and animals undergoing cardiopulmonary bypass, other reports have noted decreased levels in different demographic patient groups undergoing a wide range of procedures (Catinella et al 1983;Sciarra et al 1983;Cote 1987;Haleem et al 1990;Aglio et al 1991;Mineoi et al 1992;Sanchez-Capuchino & McConachie 1994;Place et al 1996;Scott et al 1996; Lepage et al 1999;Okuda et al 1999;Aguilera & Vaughan 2000).…”

“…Hypomagnesemia has been documented in many otherwise healthy post‐operative human subjects [American Society of Anesthesiologists (ASA) physical status (PS) I and II], and in horses with colic (Sanchez‐Capuchino & McConachie 1994; Place et al. 1996; Sasaki et al.…”

A Double-Blind Randomized Placebo Controlled Trial of Magnesium Oxide for Alleviation of Chronic Low Back Pain

“…These researchers attributed the decrease in serum magnesium to an increased urinary loss and a shift of the magnesium cation into the intracellular compartment. Sanchez-Capuchino and McConachie (1994) conducted a similar study assessing the effect of major gastrointestinal surgery on serum magnesium. This research also documents a statistically significant reduction of serum magnesium levels in patients after major surgery.…”