Hypomagnesemia and its relation with chronic low-grade inflammation in obesity

Oliveira, Ana Raquel Soares de; Cruz, Kyria Jayanne Clímaco; Silva, Juliana; Morais, Jennifer Beatriz Silva; Freitas, Taynáh Emannuelle Coelho de; Araújo, Rogério Santiago; Marreiro, Dilina do Nascimento

doi:10.1590/1806-9282.63.02.156

Cited by 30 publications

(23 citation statements)

References 47 publications

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“…Some studies reported that dietary intake of magnesium is inversely related to physiometric measures such as BMI, waist circumference, and body fat composition [33,34]. Hypomagnesemia also leads to decreased antioxidant enzyme activities, with concomitant increased production of damaging reactive oxygen species (ROS) by inflammatory cells [35].…”

Section: Introductionmentioning

confidence: 99%

Effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammatory biomarkers, and SIRT1 in obese women: a study protocol for a double-blind, randomized, placebo-controlled trial

Abiri

Vafa

2020

Trials

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Background: Emerging evidence has shown that vitamin D and magnesium have anti-inflammatory and antidepressant effects. Dietary intake of magnesium is associated with reduced body mass index, waist circumference, body fat percentage, as well as inflammatory biomarkers and depressive symptoms. Vitamin D deficiency has been linked to inflammation, obesity, and depressive symptoms. This study will test the effects of vitamin D and magnesium co-supplementation on mood, serum level of brain-derived neurotrophic factor (BDNF), inflammation, and sirtuin 1 (SIRT1) in obese women. Methods:We will conduct an 8-week, double-blind, randomized, placebo-controlled clinical trial, in a factorial design, to evaluate the individual effects of vitamin D and magnesium, and co-supplementation of them, on mood, serum level of BDNF, inflammation, and SIRT1 in 108 obese women.Discussion: We hypothesize that vitamin D and magnesium co-supplementation may provide a new adjuvant therapy through modulation of BDNF, inflammation, and SIRT1 in obese women.

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Section: Introductionmentioning

confidence: 99%

Effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammatory biomarkers, and SIRT1 in obese women: a study protocol for a double-blind, randomized, placebo-controlled trial

Abiri

Vafa

2020

Trials

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“…However, magnesium’s role as a calcium antagonist may be important. Prolonged opening of calcium channels and activation of N-methyl-D-aspartate (NMDA) receptors in the absence of magnesium leads to a cascade of events, which favor the inflammatory process [ 35 ]. In the presence of increased concentrations of intracellular calcium, phagocytic cells are activated leading to increased cytokine production [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Magnesium Intake and Chronic Pain in U.S. Adults

et al. 2020

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Chronic pain is a public health concern and additional treatment options are essential. Inadequate magnesium intake has been associated with chronic pain in some populations. We sought to examine the relationship between dietary magnesium intake and chronic pain in a large, representative cohort of U.S. adults (NHANES). Of the 13,434 eligible adults surveyed between 1999 and 2004, 14.5% reported chronic pain while 66% reported inadequate magnesium intake. The univariate analysis showed a protective effect of increased magnesium intake adjusted for body weight (odds ratio 0.92; 95%; CI 0.88, 0.95; p < 0.001). It remained so even after correcting for socioeconomic and clinical factors as well as total calorie intake (odds ratio 0.93; 95% CI 0.87, 0.99; p = 0.02). The association was stronger in females (odds ratio 0.91; 95% CI 0.85, 0.98; p = 0.01) than males (odds ratio 0.96; 95% CI 0.89, 1.04; p = 0.32). The potential protective effect of magnesium intake on chronic pain warrants further investigation.

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“…Magnesium deficiencies have been reported frequently in obesity [90][91][92][93][94][95][96][97][98][99][100][101]. Different causal factors between obesity and hypomagnesemia have been suggested.…”

Section: Low Magnesium Levels Are Often Seen In Obesitymentioning

confidence: 99%

The Use of Proton Pump Inhibitors May Increase Symptoms of Muscle Function Loss in Patients with Chronic Illnesses

Vinke

Wesselink

Orten-Luiten

et al. 2020

IJMS

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Long-term use of proton pump inhibitors (PPIs) is common in patients with muscle wasting-related chronic diseases. We explored the hypothesis that the use of PPIs may contribute to a reduction in muscle mass and function in these patients. Literature indicates that a PPI-induced reduction in acidity of the gastrointestinal tract can decrease the absorption of, amongst others, magnesium. Low levels of magnesium are associated with impaired muscle function. This unwanted side-effect of PPIs on muscle function has been described in different disease backgrounds. Furthermore, magnesium is necessary for activation of vitamin D. Low vitamin D and magnesium levels together can lead to increased inflammation involved in muscle wasting. In addition, PPI use has been described to alter the microbiota’s composition in the gut, which might lead to increased inflammation. However, PPIs are often provided together with nonsteroidal anti-inflammatory drugs (NSAIDs), which are anti-inflammatory. In the presence of obesity, additional mechanisms could further contribute to muscle alterations. In conclusion, use of PPIs has been reported to contribute to muscle function loss. Whether this will add to the risk factor for development of muscle function loss in patients with chronic disease needs further investigation.

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Hypomagnesemia and its relation with chronic low-grade inflammation in obesity

Abstract: Oliveira arS et al. 156rEv assoc mEd Bras 2017; 63(2):156-163

Cited by 30 publications

References 47 publications

Effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammatory biomarkers, and SIRT1 in obese women: a study protocol for a double-blind, randomized, placebo-controlled trial

Effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammatory biomarkers, and SIRT1 in obese women: a study protocol for a double-blind, randomized, placebo-controlled trial

Relationship between Magnesium Intake and Chronic Pain in U.S. Adults

The Use of Proton Pump Inhibitors May Increase Symptoms of Muscle Function Loss in Patients with Chronic Illnesses

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