Effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammatory biomarkers, and SIRT1 in obese women: a study protocol for a double-blind, randomized, placebo-controlled trial

Abiri, Behnaz; Vafa, Mohammadreza

doi:10.1186/s13063-020-4122-9

Cited by 22 publications

(15 citation statements)

References 46 publications

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“…Magnesium, an essential substance for basic biochemical reaction, participates in a cluster of normal physiological function and metabolism, such as the transport of potassium ion or calcium ion ( Flatman, 1984 ; Komiya and Runnels, 2015 ), energy metabolism, protein and nucleic acid synthesis ( Ohyama, 2019 ; Sissi and Palumbo, 2009 ). Magnesium also has anti-inflammation ( Abiri and Vafa, 2020 ; Eshraghi et al, 2015 ; Han et al, 2018 ; Kao et al, 2011 ; Ozen et al, 2020 ; Rochelson et al, 2007 ; Turner et al, 2017 ), anti-oxidation ( Güzel et al, 2019 ; Kao et al, 2011 ), anti-spasm ( Güzel et al, 2019 ; Yen and Thwaites, 2019 ), vasodilation ( Shimosawa et al, 2004 ; Wang et al, 2019 ), and neuroprotection ( Bachnas et al, 2019 ; Jameson and Bernstein, 2019 ). Therefore, magnesium homeostasis regulates reproductive system, cardiovascular system, digestive system, neurological system and respiratory system, etc, maintaining normal human health.…”

Section: Introductionmentioning

confidence: 99%

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

Tang

Ding

Jiao

et al. 2020

European Journal of Pharmacology

100

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Magnesium as an enzymatic activator is essential for various physiological functions such as cell cycle, metabolic regulation, muscle contraction, and vasomotor tone. A growing body of evidence supports that magnesium supplementation (mainly magnesium sulfate and magnesium oxide) prevents or treats various types of disorders or diseases related to respiratory system, reproductive system, nervous system, digestive system, and cardiovascular system as well as kidney injury, diabetes and cancer. The ongoing pandemic coronavirus disease 19 (COVID-19) characterized by respiratory tract symptoms with different degrees of important organ and tissue damages has attracted global attention. Particularly, effective drugs are still lacking in the COVID-19 therapy. In this review, we find and summarize the effectiveness of magnesium supplementation on the disorders or diseases, and provide a reference to the possibility of magnesium supplementation for supportive treatment in patients with COVID-19.

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Section: Introductionmentioning

confidence: 99%

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

Tang

Ding

Jiao

et al. 2020

European Journal of Pharmacology

100

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“…Magnesium deficiency is significantly and inversely related to the severity of infection in COVID-19 patients (Quilliot et al ., 2020). Magnesium shows anti-inflammatory (Abiri and Vafa, 2020) and antioxidant (Güzel et al ., 2019) properties and is an important cofactor for ATP, which mediates several basic enzymatic reactions (Romani and Scarpa, 1992). Nevertheless, no studies in SARS-CoV-2-infected patients with COVID-19 have examined whether a combination of the above biomarkers may be used to externally validate the diagnosis of COVID-19 and whether these pathways are associated with the presence of lowered SpO2.…”

Section: Introductionmentioning

confidence: 99%

Increased angiotensin-converting enzyme 2, sRAGE and immune activation, but lowered calcium and magnesium in COVID-19: association with chest CT abnormalities and lowered peripheral oxygen saturation

Al‐Hakeim

Al-Jassas

Morris

et al. 2021

Preprint

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Background. The characterization of new biomarkers of COVID-19 is extremely important. Few studies measured the soluble receptor for advanced glycation end product (sRAGE), angiotensin-converting enzyme 2 (ACE2), calcium and magnesium in COVID-19. Aims: To measure sRAGE, ACE2, interleukin (IL)-6, IL-10, CRP, calcium, magnesium, and albumin in COVID-19 patients in association with peripheral oxygen saturation (SpO2) and chest CT scan abnormalities (CCTA) including ground glass opacities. Methods. This study measured sRAGE, ACE2, IL-6, IL-10, CRP using ELISA techniques, and calcium, magnesium, and albumin using a spectrophotometric method in 60 COVID-19 patients and 30 healthy controls. Results. COVID-19 is characterized by significantly increased IL-6, CRP, IL-10, sRAGE, ACE2, and lowered levels of SpO2, albumin, magnesium and calcium. Neural networks showed that a combination of calcium, IL-6, CRP, and sRAGE yielded an accuracy of 100% in detecting COVID-19 patients with calcium being the most important predictor followed by IL-6, and CRP. COVID-19 patients with CCTAs showed lower SpO2 and albumin levels than those without CCTAs. SpO2 was significantly and inversely correlated with IL-6, IL-10, CRP, sRAGE, and ACE2, and positively with albumin, magnesium and calcium. Patients with positive IgG results showed a significant elevation in the serum level of IL-6, sRAGE, and ACE2 compared to the negatively IgG patient subgroup. Conclusion. The results show that immune-inflammatory and RAGE pathway biomarkers may be used as external validating criterion for the diagnosis COVID-19. Those pathways coupled with lowered SpO2, calcium and magnesium are drug targets that may help to reduce the consequences of COVID-19.

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“…As was pointed out in the introduction to this paper, low serum 25(OH)D in obese patients can occur for a number of reasons including insu cient vitamin D consumption, increased fat or muscle mass, genotype variation in vitamin D binding proteins or enzymes responsible for vitamin D metabolism (11,13). On the other hand, vitamin D de ciency can increase the risk of developing depression, through several biological pathways including effects on immunomodulation, cellular signaling, modulation of hypothalamic-pituitary-adrenal axis, intracellular calcium homeostasis, and production of neurotransmitters(6, 22) Moreover, both obesity and vitamin D de ciency lead to a chronic low-grade in ammation, which has been suggested to contribute to the development of depression (11,23). At last, it is also possible that PTH levels contribute to the relation between vitamin D, BMI, and depression.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency and Depression in Obese Adults: A Case- Control Study

Kamalzadeh¹,

Jolfaei²,

Saghafi³

2021

Preprint

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Background: Depression is one of the most prevalent psychiatric disorders reported in obese population. Amongst the contributing factors of depression, vitamin D deficiency has increasingly drawn attention in recent years. This paper seeks to examine the association between serum vitamin D level and depression in patients with obesity.Methods: This case-control study included 173 depressed obese patients and 174 non-depressed controls. Structured Clinical Interview for DSM-5 (SCID-5) was used to confirm the diagnosis of depression. 25-Hydroxyvitamin D [25(OH)D], Thyroid stimulating hormone (TSH), fasting blood sugar (FBS), parathyroid hormone (PTH) levels, and BMI were assessed in both groups. The statistical analyses included T-test, Chi-squared test, and multivariable logistic regression.Results: The mean 25(OH)D levels were significantly different between the case and control groups (20.43 ± 15.37 vs. 26.55 ± 13.17, P < .001). Vitamin D insufficiency/deficiency was detected in 77.6% and 67.4% of the case and control groups, respectively, which was significantly different (P = .034). Being female, greater age and lower vitamin D levels were associated with greater odds of developing depression (OR = 3.57, 95% CI = 1.82-7.02; OR = 1.05, 95% CI = 1.02-1.07; OR = 1.51, 95%CI = 1.16-1.96, respectively).Conclusion: The present study provides additional evidence with respect to the hypothesis that low vitamin D serum concentration is associated with depression in obese adults, and highlights the need for further research to determine whether this association is causal.

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Effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammatory biomarkers, and SIRT1 in obese women: a study protocol for a double-blind, randomized, placebo-controlled trial

Cited by 22 publications

References 46 publications

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

Increased angiotensin-converting enzyme 2, sRAGE and immune activation, but lowered calcium and magnesium in COVID-19: association with chest CT abnormalities and lowered peripheral oxygen saturation

Vitamin D Deficiency and Depression in Obese Adults: A Case- Control Study

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