Hypomagnesaemia in cystic fibrosis patients referred for lung transplant assessment

Gupta, Ajay; Eastham, Katherine; Wrightson, Neil; Spencer, David A.

doi:10.1016/j.jcf.2007.01.004

Cited by 22 publications

(26 citation statements)

References 12 publications

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“…Furthermore, in CF patients, trace elements balance is also influenced by impaired chloride efflux in CF airway epithelium, the most important hallmarks of CF [19], [20], [33], [56], [57]. In particular, specific mutations of CF transmembrane conductance regulator (CFTR) significantly affected metal homeostasis in vitro [58].…”

Section: Discussionmentioning

confidence: 99%

Stenotrophomonas maltophilia Virulence and Specific Variations in Trace Elements during Acute Lung Infection: Implications in Cystic Fibrosis

et al. 2014

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Metal ions are necessary for the proper functioning of the immune system, and, therefore, they might have a significant influence on the interaction between bacteria and host. Ionic dyshomeostasis has been recently observed also in cystic fibrosis (CF) patients, whose respiratory tract is frequently colonized by Stenotrophomonas maltophilia. For the first time, here we used an inductively mass spectrometry method to perform a spatial and temporal analysis of the pattern of changes in a broad range of major trace elements in response to pulmonary infection by S. maltophilia. To this, DBA/2 mouse lungs were comparatively infected by a CF strain and by an environmental one. Our results showed that pulmonary ionomic profile was significantly affected during infection. Infected mice showed increased lung levels of Mg, P, S, K, Zn, Se, and Rb. To the contrary, Mn, Fe, Co, and Cu levels resulted significantly decreased. Changes of element concentrations were correlated with pulmonary bacterial load and markers of inflammation, and occurred mostly on day 3 post-exposure, when severity of infection culminated. Interestingly, CF strain – significantly more virulent than the environmental one in our murine model - provoked a more significant impact in perturbing pulmonary metal homeostasis. Particularly, exposure to CF strain exclusively increased P and K levels, while decreased Fe and Mn ones. Overall, our data clearly indicate that S. maltophilia modulates pulmonary metal balance in a concerted and virulence-dependent manner highlighting the potential role of the element dyshomeostasis during the progression of S. maltophilia infection, probably exacerbating the harmful effects of the loss of CF transmembrane conductance regulator function. Further investigations are required to understand the biological significance of these alterations and to confirm they are specifically caused by S. maltophilia.

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Section: Discussionmentioning

confidence: 99%

Stenotrophomonas maltophilia Virulence and Specific Variations in Trace Elements during Acute Lung Infection: Implications in Cystic Fibrosis

et al. 2014

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“…2ϩ deficiency has been repeatedly reported in patients with cystic fibrosis (210,380). Patients with cystic fibrosis are often treated with recombinant human DNase-I to degrade the viscous mucus.…”

Section: Mgmentioning

confidence: 99%

Magnesium in Man: Implications for Health and Disease

Baaij

Hoenderop

Bindels

2015

Physiological Reviews

1,245

1,299

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“…Intracellular GTP as a cause of perturbed GTP-Rab27a levels in CF neutrophils was excluded as no significant difference between HC and CF neutrophils was detected (n 5 3, P 5 .90; Figure 5C). To rule out hypomagnesaemia 52 as a potential cause for lower cytosolic Mg 21 levels in circulating CF neutrophils, serum Mg 21 levels of PWCF recruited to this study were analyzed. No statistical difference in serum Mg 21 levels was detected between HC (0.83 6 0.02 mM) and CF samples (0.82 6 0.01 mM) (n 5 28, P 5 .6), and the mean values of both groups were higher than the 0.75 mM reference for hypomagnesaemia ( Figure 5D).…”

Section: Blood 14 August 2014 X Volume 124 Number 7 Cftr Potentiatomentioning

confidence: 99%

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy

Pohl

Hayes

Keenan

et al. 2014

Blood

144

146

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Hypomagnesaemia in cystic fibrosis patients referred for lung transplant assessment

Abstract: Hypomagnesaemia is a common finding in patients with CF referred for lung transplant assessment. Serum magnesium levels should be monitored in all CF patients being referred for lung transplant irrespective of the results of other renal function tests.

Cited by 22 publications

References 12 publications

Stenotrophomonas maltophilia Virulence and Specific Variations in Trace Elements during Acute Lung Infection: Implications in Cystic Fibrosis

Stenotrophomonas maltophilia Virulence and Specific Variations in Trace Elements during Acute Lung Infection: Implications in Cystic Fibrosis

Magnesium in Man: Implications for Health and Disease

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy

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