Hypolipidemic principles of<i>Cicer Arietinum</i>: Biochanin‐A and formononetin

Siddiqui, M. Tauseef; Siddiqi, Majid

doi:10.1007/bf02532865

Cited by 53 publications

(13 citation statements)

References 10 publications

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“…Biochanin A (5, 7-Dihydrox-4’-methoxyisoflavone, abbreviated as BCA) is the main effective component of Trifolium pratense L. , which has estrogen-like characteristics and is mainly used in the treatment of menopausal syndrome in women 10 , 11 . It has been revealed that BCA has a variety of pharmacological effects, such as anti-tumor, anti-inflammatory, anti-osteoporosis, antibacterial, hypolipidemic, etc 12 – 16 . Previous studies have proved that BCA can inhibit inflammatory responses in a variety of diseases.…”

Section: Introductionmentioning

confidence: 99%

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway

Bai

Liu

et al. 2019

Acta Cir. Bras.

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Purpose:Myocardial ischemia/reperfusion (Ml/R) injury is a leading cause of damage in cardiac tissues, with high rates of mortality and disability. Biochanin A (BCA) is a main constituent of Trifolium pratense L. This study was intended to explore the effect of BCA on Ml/R injury and explore the potential mechanism.Methods: In vivo MI/R injury was established by transient coronary ligation in Sprague-Dawley rats. Triphenyltetrazolium chloride staining (TTC) was used to measure myocardial infarct size. ELISA assay was employed to evaluate the levels of myocardial enzyme and inflammatory cytokines. Western blot assay was conducted to detect related protein levels in myocardial tissues.Results:BCA significantly ameliorated myocardial infarction area, reduced the release of myocardial enzyme levels including aspartate transaminase (AST), creatine kinase (CK-MB) and lactic dehydrogenase (LDH). It also decreased the production of inflammatory cytokines (IL-1β, IL-18, IL-6 and TNF-α) in serum of Ml/R rats. Further mechanism studies demonstrated that BCA inhibited inflammatory reaction through blocking TLR4/NF-kB/NLRP3 signaling pathway.Conclusion:The present study is the first evidence demonstrating that BCA attenuated Ml/R injury through suppressing TLR4/NF-kB/NLRP3 signaling pathway-mediated anti-inflammation pathway.

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Section: Introductionmentioning

confidence: 99%

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway

Bai

Liu

et al. 2019

Acta Cir. Bras.

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“…It is involved in the fracture-repair process, as evidenced by its role in enhancing bone regeneration in a mouse model of cortical bone defect [9]. Moreover, it has hypolipidemic properties and free radical scavenging activity that prevent the formation of lipid peroxidation [10, 11]. FMNT is also reported to have a neuroprotective effect against oxidative stress and excitotoxicity instigated by hydrogen peroxide and L-glutamate [12, 13].…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic effects of Formononetin in an inflammatory pain mouse model

et al. 2019

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Chronic pain is commonly accompanied with anxiety disorder, which complicates treatment. In this study, we investigated the analgesic and anxiolytic effects of Formononetin (FMNT), an active component of traditional Chinese medicine red clover ( Trifolium pratense L.) that is capable of protecting neurons from N-methyl-D-aspartate (NMDA)-evoked excitotoxic injury, on mice suffering from complete Freund’s adjuvant (CFA)-induced chronic inflammatory pain. The results show that FMNT administration significantly reduces anxiety-like behavior but does not affect the nociceptive threshold in CFA-injected mice. The treatment reverses the upregulation of NMDA, GluA1, and GABA A receptors, as well as PSD95 and CREB in the basolateral amygdala (BLA). The effects of FMNT on NMDA receptors and CREB binding protein (CBP) were further confirmed by the potential structure combination between these compounds, which was analyzed by in silico docking technology. FMNT also inhibits the activation of the NF-κB signaling pathway and microglia in the BLA of mice suffering from chronic inflammatory pain. Therefore, the anxiolytic effects of FMNT are partially due to the attenuation of inflammation and neuronal hyperexcitability through the inhibition of NMDA receptor and CBP in the BLA. Electronic supplementary material The online version of this article (10.1186/s13041-019-0453-4) contains supplementary material, which is available to authorized users.

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“…[ 23 ] Further, several research works have demonstrated the cholesterol lowering effects of C. arientum in different types of hyperlipidemias such as induced by diet[ 24 25 26 ] or triton. [ 27 ] The sprout extracts of chickpea were able to prevent estrogen deficiency induced bone loss. [ 23 ] However, the antihyperlipidemic effect of C. arientum was not studied in estrogen deficiency-induced hyperlipidemia.…”

Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic activity of chickpea sprouts supplementation in ovariectomy-induced dyslipidemia in rats

Harini

Adilaxmamma²,

Mohan

et al. 2015

J Ayurveda Integr Med

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Background:Phytoestrogens are increasingly becoming popular as alternatives for hormone replacement therapy in postmenopausal condition.Objective:In this study, the antihyperlipidemic effect of chickpea (Cicer arientum) sprouts was evaluated in ovariectomy-induced dyslipidemia in rat model in comparison with standard antihyperlipidemic agent atorvastatin.Materials and Methods:A total of 24 female adult Wistar rats were divided into four groups that is, Group I - Control; Group II - Ovariectomized (OVX) rats; Group III - OVX + germinated chickpea sprouts (20% in diet) and Group IV OVX + atorvastatin (1.2 mg/kg b.wt, p.o.). Body and organ weights, serum, and liver lipid profile were assessed at the end of 8 weeks.Results:The results indicated that ovariectomy significantly (P < 0.05) increased total cholesterol, nonhigh-density lipoprotein cholesterol and triglycerides (TGs) in serum and liver. The total lipid and phospholipid content in liver were also significantly (P < 0.05) increased. The weights of uterus and heart were significantly (P < 0.05) decreased. Dietary supplementation with germinated chickpea normalized the lipid profile in serum and liver. Further, high-density lipoprotein (HDL) cholesterol, body weight, uterine, heart, and spleen weights were significantly (P < 0.05) increased. Atorvastatin administration showed similarly normalized lipid profile, but showed no improvement on decreased uterus and heart weights. Histopathological examination revealed fatty changes in liver, uterine atrophy, and subintimal fat accumulation in aorta in OVX group. The changes were mild in chickpea group with no improvement in statin group.Conclusions:Germinated seeds of chickpea showed significant antihyperlipidemic activity, which was comparable to atorvastatin. Further, germinated chickpea improved organ weights and helped in the reversal of histopathological changes suggesting its usefulness in postmenopausal condition.

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Hypolipidemic principles ofCicer Arietinum: Biochanin‐A and formononetin

Abstract: Two isoflavones, biochanin-A and formononetin isolated from gram Cicer arietinum, have been shown to possess hypolipidemic properties for Triton WR-1339 induced hyperlipidemia in male albino rats, when administered as a crude extract or as individual compounds.

Cited by 53 publications

References 10 publications

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway

Anxiolytic effects of Formononetin in an inflammatory pain mouse model

Antihyperlipidemic activity of chickpea sprouts supplementation in ovariectomy-induced dyslipidemia in rats

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