Hypolipidemic potential of flowers of <i>Nerium oleander</i> in high fat diet-fed Sprague Dawley rats

Gayathri, Veeraraghavan; Ananthi, S.; Chandronitha, Chandranayagam; Sangeetha, Marimuthu Kannan; Vasanthi, Hannah R.

doi:10.1080/14786419.2010.541883

Cited by 14 publications

(14 citation statements)

References 9 publications

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“…In addition, Gayathri et al,[37] demonstrated that a bioactive fraction of Nerium flower prevented elevation of LDH, GGT, AST, ALT, ALP and creatinine levels in isoproterenol-induced oxidative stress in rats. In an interconnected study, Gayathri et al,[38] further demonstrated hypolipidemic capacity of Nerium flower which corroborates the LDH and cholesterol lowering potentials of NILE in the present study.…”

supporting

confidence: 94%

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Assessment of hepatoprotective potential of N. indicum leaf on haloalkane xenobiotic induced hepatic injury in Swiss albino mice

Dey

Dutta

Sarkar

et al. 2015

Chemico-Biological Interactions

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supporting

confidence: 94%

“…Compared to control, lower weight gain was observed in NILE treated groups. This may have resulted due to body weight lowering capacity of Nerium contributing to its potent anti-hyperlipidemic activity as demonstrated by Gayathri et al, [38].…”

Section: Discussionmentioning

confidence: 91%

Assessment of hepatoprotective potential of N. indicum leaf on haloalkane xenobiotic induced hepatic injury in Swiss albino mice

Dey

Dutta

Sarkar

et al. 2015

Chemico-Biological Interactions

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“…Compared to control and silymarin group, the final body weight change in the extract treated groups were much less. This may presumably indicate the potentiality of oleander extracts to restrict body weight increase through anti-hyperlipidemic activity as demonstrated previously by body weight lowering capability of oleander [30]. Compared to control, 1.80 fold higher relative liver weight in the CCl 4 group reflected formation of fatty liver which was further supported by increased blood cholesterol level and extensive steatosis throughout the CCl 4 intoxicated liver samples.…”

Section: Discussionsupporting

confidence: 70%

Haloalkane induced hepatic insult in murine model: amelioration by Oleander through antioxidant and anti-inflammatory activities, an in vitro and in vivo study

Dey

Dutta

Biswas-Raha

et al. 2016

BMC Complement Altern Med

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BackgroundNerium oleander L. (syn. Nerium indicum Mill, Nerium odorum Aiton) belongs to the family Apocynaceae. It is used for its anti-inflammatory, anti-diabetic, anti-cancer and hepatoprotective activities in traditional medicine. Previous pharmacognostic studies suggested that 70 % hydro-methanolic extracts of oleander possess potent free radical scavenging and anti-inflammatory activities, both of which are helpful against hepatotoxicity.MethodsHydro-methanolic extracts of oleander stem and root were evaluated for their hepatoprotective activities in acute CCl4 intoxicated mouse through in vitro and in vivo studies. Silymarin was used as positive reference. Antioxidant enzymes, pro-inflammatory markers and liver enzymatic and biochemical parameters were studied. The extracts were further chemically characterized using Fourier Transform Infrared (FTIR) spectroscopy and Gas chromatography-mass spectrometry (GC-MS).ResultsCCl4 toxicity caused fatty liver formation by increase of relative liver weight (32.53 g) compared to control group (16.08 g). The elevated liver enzymatic and biochemical parameters due to CCl4 toxicity were considerably normalized by the extracts treatment under both in vivo and in vitro models. Oleander stem (NOSE) and root (NORE) extracts increased the reduced hepatic catalase activity 27.37 and 25.25 %, whereas peroxidase activity was increased 18.19 and 22.78 %, respectively. The extent of lipid peroxidation was significantly (p < 0.01) lowered 20.76 % (NOSE) and 21.12 % (NORE) compared to CCl4 group. The levels of pro-inflammatory tumor necrosis factor-α (TNF-α) was lowered 71.33 % (NOSE) and 61.60 % (NORE). Histopathological study demonstrated substantial reduction of hepatocellular necrosis, fatty infiltration, sinusoidal dilation, bile duct proliferation, vascular congestion, leukocyte infiltration in the silymarin and extract treated groups. Furthermore, various bioactive compounds were identified in the extracts such as apocynin, tocopherol, squalene, vanillin, isoeugenol, amyrin, lupeol etc.ConclusionThe present study provided convincing evidence that oleander extracts possess potent hepatoprotective capacity which was primarily governed by its antioxidant and anti-inflammatory activities. The collegial bioactivities of the phytochemicals may be accredited behind the hepatoprotective activity of oleander.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1260-4) contains supplementary material, which is available to authorized users.

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“…leaflets. Similarly; Gayathri et al 27 found that N.O. extract had an antilipidemic effect in high fat diet fed rats.…”

Section: Discussionmentioning

confidence: 99%

Increased Glucose Uptake and Insulin Binding Activity of Nerium Oleander in Hepatocytes and Adipocytes

Yazıhan¹,

Baş²,

Ermiş³

et al. 2013

Kafkas Univ Vet Fak Derg

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Type 2 diabetes mellitus (DM) affects a large population worldwide. DM is often considered as a syndrome of disordered glucose metabolism. Current conventional drug therapies for DM are usually insufficient and medicinal herbs with antihyperglycemic activities are increasingly sought by diabetic patients and health care professionals. Nerium Oleander (N.O.) is known to be effective in lowering of postprandial blood glucose in DM patients as a folk remedy. In this study we aimed to evaluate effect of N.O. distillate in glucose uptake activity of hepatocytes and adipocytes. The human hepatoma cells Hep3B and mouse adipocyte 3T3-L1 cells were cultured. Depending on the groups, different concentrations insulin (1, 10, 20 IU/ml) and N.O. (0.1, 1, 10, 50 µg/ml) were added to medium for 48 h. Cellular toxicity and proliferation were evaluated by LDH secretion levels and MTT test. A metabolizable fluorescent derivative of glucose, 2-NBDG and FITC-insulin were used for glucose uptake and insulin binding activity. Insulin increased cellular proliferation and decreased LDH leakage and apoptosis in both cell types. Lower dosages of N.O. has no significant effect on apoptosis and cell number while at the highest dosages minimal cytotoxicity was seen mainly in adipocytes. Main effect of N.O. treatment was increased glucose uptake in Hep3B and 3T3-L1 cells (P<0.001). Our results showed that N.O. may be offered as new approaches to treatment of type 2 diabetes by modulating cellular glucose uptake.

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Hypolipidemic potential of flowers of Nerium oleander in high fat diet-fed Sprague Dawley rats

Cited by 14 publications

References 9 publications

Assessment of hepatoprotective potential of N. indicum leaf on haloalkane xenobiotic induced hepatic injury in Swiss albino mice

Assessment of hepatoprotective potential of N. indicum leaf on haloalkane xenobiotic induced hepatic injury in Swiss albino mice

Haloalkane induced hepatic insult in murine model: amelioration by Oleander through antioxidant and anti-inflammatory activities, an in vitro and in vivo study

Increased Glucose Uptake and Insulin Binding Activity of Nerium Oleander in Hepatocytes and Adipocytes

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