Hypolipidemic effect of resistant starch in hamsters is not dose dependent

Ranhotra, G. S.; Gelroth, J. A.; Leinen, S. D.

doi:10.1016/s0271-5317(96)00261-8

Cited by 18 publications

(7 citation statements)

References 5 publications

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“…There are a lot of in vivo studies on the physiological effect of resistant starch (Björk et al, 1989;De Deckre et al, 1993;Lajvardi et al, 1993;Marlett & Longacre, 1996;Morais et al, 1996;Ranhotra et al, 1997;Vanhoof & De Schrijver, 1997;Ebihara et al, 1998;Vanhoof & De Schrijver, 1998;De Schrijver et al, 1999;Cheng & Lai, 2000;Kishida et al, 2001a;Lopez et al, 2001;Juśkiewicz et al 2005;Satniek et al, 2005;Kanazawa et al, 2008;Anioła et al, 2009;Orzeł et al, 2009;Wronkowska et al, 2011;Lee et al, 2012). However, the results published by different research groups are difficult to compare.…”

Section: Discussionmentioning

confidence: 99%

Type IV resistant starch increases cecum short chain fatty acids level in rats.

et al. 2014

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Resistant starches are type of dietary fibers. However, their physiological effects depend on the way they resist digestion in the gastrointestinal tract. The objective of this study was to examine the hypothesis that new type of RS4 preparations, of in vitro digestibility of about 50%, obtained by cross-linking and acetylation, acts as a prebiotic by increasing short chain fatty acids content in cecum digesta. The rats were fed with diet containing pregelatinized, cross-linked and acetylated starches as a main carbohydrate source. Pregelatinized, but not chemically modified, potato starch was used in the composition of the control diet. After two weeks of experiment the increase of short chain fatty acids contents in ceceum digesta was observed. The intake of starch A, cross-linked only with adipic acid, resulted in increase of about 40% of short chain fatty acids content, whereas starch PA cross-linked with sodium trimetaphosphate and adipic acid of about 50%. The utmost twofold increase was observed in the case of the production of propionic acid. In contrast, the content of butyric acid increased (12%) only as an effect of consumption of starch PA and even decreased (about 30%) in case of starch A. Both RS4 starches caused an increase of the production of acetic acid by more than 40%. No changes in serum biochemistry, liver cholesterol and organ weights of rats were stated.

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Section: Discussionmentioning

confidence: 99%

Type IV resistant starch increases cecum short chain fatty acids level in rats.

et al. 2014

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“…Model studies with humans [1,10] and rats [3] showed that RS3 was fermented by intestinal micro flora; this fermentation is beneficial to human health [11]. Ranhotra et al [12,13] reported that hamsters fed with a high level of RS3 showed a significant lowering of blood cholesterol and triglyceride levels as compared to hamsters fed with digestible starch.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Resistant Starch (RS3) in Amylomaize, Barley, Field Pea and Lentil Starches

Vasanthan

Bhatty

1998

Starch/Stärke

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Native starches isolated from amylomaize. Glacier high amylose barley, field peas and lentils contained 3–5% (w/w) resistant starch (RS3). Retrograded gels that were prepared from these starches had higher RS3 (6–9%) contents. The effects of gel concentration (% starch), storage temperature and time on the RS3 content of the retrograded gels were investigated; the optimum RS3 content was determined in gels prepared at = 10% (w/v) starch concentration and stored under = 20°C for = 5 days. Annealing of the retrograded starch gels by heating and cooling cycles, further enhanced RS3 content to 9–19%; the effect of annealing temperature and number of heat‐cool cycles on the RS3 content of the annealed gel were studied. The hydrolysis of retrograded starch gels by pulanase enzyme or acid (2.2 N HCl), prior to annealing, enhanced the RS3 formation during annealing; the enzyme or acid treatment increased RS3 content of the annealed gel to 15–24% or 17–24%, respectively. The potential molecular mechanism that is responsible for the RS3 increase is discussed.

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“…High-amylose corn starch (HACS) contains RS2, ungelatinized starch granules that are highly resistant to digestion by ␣-amylase until gelatinized. Several studies have shown that HACS (RS2) reduces serum cholesterol and triglyceride concentrations in rats (17,30,53) and hamsters (49).…”

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confidence: 99%

RS4-type resistant starch prevents high-fat diet-induced obesity via increased hepatic fatty acid oxidation and decreased postprandial GIP in C57BL/6J mice

Shimotoyodome

Suzuki

Fukuoka

et al. 2010

American Journal of Physiology-Endocrinology and Metabolism

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Shimotoyodome A, Suzuki J, Fukuoka D, Tokimitsu I, Hase T. RS4-type resistant starch prevents high-fat diet-induced obesity via increased hepatic fatty acid oxidation and decreased postprandial GIP in C57BL/6J mice. Am J Physiol Endocrinol Metab 298: E652-E662, 2010. First published December 15, 2009 doi:10.1152/ajpendo.00468.2009.-Chemically modified starches (CMS) are RS4-type resistant starch, which shows a reduced availability, as well as high-amylose corn starch (HACS, RS2 type), compared with the corresponding unmodified starch. Previous studies have shown that RS4 increases fecal excretion of bile acids and reduces zinc and iron absorption in rats. The aim of this study was to investigate the effects of dietary RS4 supplementation on the development of diet-induced obesity in mice. Weight-and agematched male C57BL/6J mice were fed for 24 wk on a high-fat diet containing unmodified starch, hydroxypropylated distarch phosphate (RS4), or HACS (RS2). Those fed the RS4 diet had significantly lower body weight and visceral fat weight than those fed either unmodified starch or the RS2 diet. Those fed the RS4 diet for 4 wk had a significantly higher hepatic fatty acid oxidation capacity and related gene expression and lower blood insulin than those fed either unmodified starch or the RS2 diet. Indirect calorimetry showed that the RS4 group exhibited higher energy expenditure and fat utilization compared with the RS2 group. When gavaged with fat (trioleate), RS4 stimulated a lower postprandial glucose-dependent insulinotropic polypeptide (GIP; incretin) response than RS2. Higher blood GIP levels induced by chronic GIP administration reduced fat utilization in high-fat diet-fed mice. In conclusion, dietary supplementation with RS4-type resistant starch attenuates high-fat diet-induced obesity more effectively than RS2 in C57BL/6J mice, which may be attributable to lower postprandial GIP and increased fat catabolism in the liver.glucose-dependent insulinotropic polypeptide; insulin RESISTANT STARCH (RS) is defined as the sum of starch and the products of starch degradation not absorbed in the small intestine of healthy individuals (6). According to the standard method of the American Association of Cereal Chemists to determine dietary fiber (DF) levels (4), RS is an insoluble DF (48) that escapes hydrolysis in the small intestine and enters the large intestine (5). In this regard, RS possesses physiological properties similar to those of DF (10).RS is currently divided into four categories: physically inaccessible starch (RS1), resistant granules and high-amylose starches (RS2), retrograded starches (RS3), and chemically modified starches (CMS; RS4) (22). High-amylose corn starch (HACS) contains RS2, ungelatinized starch granules that are highly resistant to digestion by ␣-amylase until gelatinized. Several studies have shown that HACS (RS2) reduces serum cholesterol and triglyceride concentrations in rats (17,30,53) and hamsters (49).CMS are RS4-type resistant starch, which are more resistant to retrogradation, hav...

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Hypolipidemic effect of resistant starch in hamsters is not dose dependent

Cited by 18 publications

References 5 publications

Type IV resistant starch increases cecum short chain fatty acids level in rats.

Type IV resistant starch increases cecum short chain fatty acids level in rats.

Enhancement of Resistant Starch (RS3) in Amylomaize, Barley, Field Pea and Lentil Starches

RS4-type resistant starch prevents high-fat diet-induced obesity via increased hepatic fatty acid oxidation and decreased postprandial GIP in C57BL/6J mice

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