Hypolipidemic Effect of Ginger Extract in Vanaspati Fed Rats

Paul, Pascale; Islam, Khairul; Mustari, Afrina; Khan, M. Z. I.

doi:10.3329/bjvm.v10i1-2.15652

Cited by 8 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…GR constituents also alleviate TC levels via another reported mechanism of upgrading hepatic cholesterol 7α-hydroxylase activity. This is a rate-limiting enzyme in the conversion of serum free cholesterol to bile acids and downregulating HMGR genes (responsible for encoding rate-limiting enzymes in cholesterol biosynthesis), hence lowering serum TC and the risk of coronary heart disease [48,51]. Remarkably reduced levels ( p < 0.05) of vLDL-C, LDL-C, and triglycerides and elevated levels of HDL-C can be explained by the presence of niacin in GR extracts.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective and Renoprotective Properties of Lovastatin-Loaded Ginger and Garlic Oil Nanoemulsomes: Insights into Serum Biological Parameters

et al. 2019

View full text Add to dashboard Cite

Background and Objectives: Dyslipidemia is gaining much attention among healthcare professionals because of its high association with the malfunctioning of a number of normal physiological and metabolic processes in the body. Obesity is directly interconnected with dyslipidemia and is said to be a denouement of hyperlipidemia and, if left untreated, may lead to intense damage to organs that are directly involved in fat metabolism. The objective of this study was to investigate the synergistic antiobesity and anti-hyperlipidemic activities along with hepato- and renoprotective potential of nanoemulsomes (NES) of lovastatin (LTN)-loaded ginger (GR) and garlic (GL) oils. Materials and Methods: LTN nanoemulsomes co-encapsulated with GR oil and GL oil were prepared by a thin hydration technique. Eight-week-old male Wistar rats weighing 200–250 g were induced with hyperlipidemia via a high-fat diet (HFD) comprising 40% beef tallow. Body weight, serum biochemical lipid parameters, and those for liver and kidney functions, serum TC, LDL-C, vLDL-C, HDL-C, TG, atherogenic index (AI), ALT, AFT, ALP, γ-GT, total protein (TP), serum albumin and globulin ratio (A/G), serum creatinine, blood urea nitrogen (BUN) and blood urea, and histopathology of hematoxylin and eosin (H&E) stained liver and kidney sections of all aforementioned groups were examined in the treated animals. Results: Nanoemulsomes of LTN-loaded GR and GL oils provided synergistic effects with LTN, exerted better ameliorative actions in reducing serum TC, LDL-C, vLDL-C, triglycerides, and AI, and improved serum HDL-C levels. Serum ALT, AST, ALP, and γ-GT levels were in the normal range for nanoemulsome groups. H&E stained liver and kidney sections of these animals confirmed better hepatoprotective and renoprotective effects than LTN alone. Serum biochemical parameters for renal functions also claimed to be in the moderate range for nanoemulsome-treated groups. Conclusion: This study demonstrated that nanoemulsomes of LTN-loaded GR and GL oils synergistically provided better antihyperlipidemic, hepatoprotective, and renoprotective effects as compared to LTN alone.

show abstract

Section: Discussionmentioning

confidence: 99%

Hepatoprotective and Renoprotective Properties of Lovastatin-Loaded Ginger and Garlic Oil Nanoemulsomes: Insights into Serum Biological Parameters

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Paul et al, 2012 confirmed that it has hypolipidemic activity in animal experiment [9]. Srivastava and Mustafa (1992) proved that it is useful for rheumatism and musculoskeletal disorders through clinical trials [10].…”

Section: Introductionmentioning

confidence: 89%

INDIAN TRADITIONAL MEDICINE - A CONGLOMERATION OF ANCIENT KNOWLEDGE AND MODERN SCIENCE (21-22 July 2016: Phytocongress | Sastra University)

University¹

2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

PHYTOCONGRESS – 2016 The International Conference Phytocongress – 2016 on the theme “Indian Traditional Medicine - A Conglomeration of Ancient Knowledge and Modern Science” was organized by Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur on 21 & 22 July 2016. This conference was focused on the vast, enviable traditional wealth of India, practices and usage of plant drugs, metals, minerals and animals by traditional medical practitioners during ancient times and the current status of traditional and synthetic drugs. This programme analyzed the requirements of modern times and how the same could be benefited through ancient wisdom. Sessions in the seminar covered a wide range of topics emphasizing the scientific merits involved in Ayurveda and Siddha medicines. These sessions highlighted the significance and importance of evidence based studies on traditional medicines and finding new experimental methodologies for their characterization using various sophisticated analytical techniques and their applications. The modern tools of chemistry and biology, in particular allow scientists to detail the exact nature of the biological effects of natural compounds on the human body, as well as to uncover possible synergies, which holds much promise for the discovery of new therapies against many devastating diseases. With the technology at hand today, we can validate the science behind this ancient knowledge and unravel the mysteries behind why and how traditional medicine works. The challenge today is to integrate the best of the different healing traditions to meet the healthcare needs of contemporary society. This International conference brought together leading academic scientists, researchers and research scholars to exchange and share their experiences and wisdom on all aspects of medicinal plants and natural products. It also provided an interdisciplinary platform for researchers, practitioners and educators to present and discuss the most recent innovations, trends, and concerns as well as practical challenges encountered and solutions to be adopted in the fields of medicinal plants and natural products. This conference was inaugurated by Prof. Bhushan Patvarthan, University of Pune, and this Conference was convened by Prof. P. Brindha, Associate Dean and Co-ordinator, CARISM, SATRA University. Invited international speakers from USA, Australia and Malaysia and national speakers gave scintillating lectures covering various aspects on the theme of the conference. Altogether nearly 200 Scientists, Siddha and Ayurveda Researchers, Practitioners and Industrialists participated from various parts of India.

show abstract

“…These distinct properties prevent development of atherosclerosis. [25][26][27][28][29][30][31][32][33][34][35][36]…”

Section: Prevention Of Atherosclerosismentioning

confidence: 99%

Cardioprotective effects of ginger (Zingiber officinale)

Shivananjappa

2022

SAJHP

View full text Add to dashboard Cite

Ginger is the rhizome of the plant In ayurveda, it is referred as “vishwabheshaja” which means the universal medicine, can be given to anyone living in this world and it would be suited to all. In addition to its culinary use ginger also possess medicinal property by bioactive components present in them. Ginger can be used in its fresh, dried, powdered, oil and syrup forms. Ginger is an herbal remedy and reported to possess strong anti-diabetic, anti-inflammatory, anti-oxidant, anti-microbial and other activities. The present review is conducted to evaluate cardioprotective effect of ginger. Ginger was found effective in combating cardiovascular disease such as hypertension, obesity, atherosclerosis by changing lipid profile.

show abstract

Hypolipidemic Effect of Ginger Extract in Vanaspati Fed Rats

Cited by 8 publications

References 18 publications

Hepatoprotective and Renoprotective Properties of Lovastatin-Loaded Ginger and Garlic Oil Nanoemulsomes: Insights into Serum Biological Parameters

Hepatoprotective and Renoprotective Properties of Lovastatin-Loaded Ginger and Garlic Oil Nanoemulsomes: Insights into Serum Biological Parameters

INDIAN TRADITIONAL MEDICINE - A CONGLOMERATION OF ANCIENT KNOWLEDGE AND MODERN SCIENCE (21-22 July 2016: Phytocongress | Sastra University)

Cardioprotective effects of ginger (Zingiber officinale)

Contact Info

Product

Resources

About