Hypolipidemic activity of Moringa oleifera Lam., Moringaceae, on high fat diet induced hyperlipidemia in albino rats

Abstract

RESUMO: "Atividade hipolipidemica de Moringa oleifera Lam., Moringaceae, na hiperlipidemia induzida por dieta rica em gordura em ratos albinos." As Unitermos: Moringa oleifera, HMG Co-A reductase, hypolipidemic effect, lipid profile. ABSTRACT:The leaves of Moringa oleifera Lam., Moringaceae, are used by the Indians in their herbal medicine as a hypolipidemic agent in obese patients. Albino Wistar rats were fed with methanolic extract of M. oleifera (150, 300 and 600 mg/kg, p.o.) and simvastatin (4 mg/ kg, p.o.) along with hyperlipidemic diet for 30 days. Moringa oleifera and simvastatin were found to lower the serum cholesterol, triacylglyceride, VLDL, LDL, and atherogenic index, but were found to increase the HDL as compared to the corresponding high fed cholesterol diet group (control). The Moringa oleifera methanolic extract was also investigated for its mechanism of action by estimating HMG CO-A reductase activity. Moringa oleifera was found to increase the excretion of fecal cholesterol. Thus, the study demonstrates that M. oleifera possesses a hypolipidemic effect.

Cholesterol Lowering Potentials of a Blend of Standardized Methanol Extracts of Moringa Oleifera Leaves and Fruits in Albino Wistar Rats

“…However, a study on extract blends of M. oleifera is not reported so far. The hypo cholesterol activity of Moringa leaves in high cholesterol diet model has been reported at a dose of 1000 mg/kg body weight for water extract and 600 mg/kg body weight for methanol extract respectively [32,33]. Similar results for fruit were reported in rabbits at a dose of 200 mg/kg/day [15].…”

Phytochemical Constituents, Biological Activities, Therapeutic Potentials and Nutritional Values of <i>Moringa oleifera</i> (Zogale): A Review

“…The Moringa leaf water and methanol extract are also reported to have antidyslipidemic effects to lower the serum total cholesterol (TC), triacylglyceride (TG), very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and the atherogenic index, with increased high-density lipoprotein (HDL) in rats fed on a high-fat diet (HFD). A significant rise in the fecal excretion of cholesterol is observed in treated animals compared to the HFD control group [55]. Similar antidyslipidemic effects are also documented in hyperlipidemic patients (TC[180 mg/dL and TG[140 mg/dL), fed with leaf tablets (4.6 g/day) for 40-50 days [56].…”

Healing Effect of Moringa oleifera Lam against UV-B Induced Psoriasis form Changes in Rats

“…The pharmacological activities of M. oleifera may be due to various secondary plant metabolites present in M. oleifera such as flavonoids, phenolics, vitamins, carotenoids, minerals, sterols, amino acids, alkaloids, and glycosides [34]. M. oleifera leaves contains phenolic acids such as quinic acid and chlorogenic acid that exhibit high antioxidant activities [35,36] and recently β-sitosterol, was isolated from Moringa leaves fraction [37]. The antipsoriatic activity observed in the present study may be due to the presence of various phytoconstituents especially flavonoids in the extract which inhibited the proliferation of keratinocyte and enhanced the keratinization process.…”