Hypolipidaemic Effect of Fenugreek Seeds: a Chronic Study in Non-insulin Dependent Diabetic Patients

Sharma, Rakesh; Sarkar, A.; Hazra, D. K.; Misra, Biswapriya B.; Singh, Joginder; Maheshwari, B. B.; Sharma, Sushma

doi:10.1002/(sici)1099-1573(199606)10:4<332::aid-ptr827>3.0.co;2-j

Cited by 79 publications

(33 citation statements)

References 11 publications

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“…A substantial body of evidence has revealed that supplementation of fenugreek seed prevents hyperlipidemia, atherosclerosis (Sharma et al 1996), diabetes (Sharma 1986), cancer (Sur et al 2001), andulcer (Suja Pandian et al 2002) in experimental animals. In a previous study, we found that FPEt was able to scavenge O À 2 and H 2 O 2 (Kaviarasan et al 2007b).…”

Section: Discussionmentioning

confidence: 99%

Protective action of fenugreek (Trigonella foenum graecum) seed polyphenols against alcohol-induced protein and lipid damage in rat liver

2008

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The study investigates the effect of fenugreek seed polyphenol extract (FPEt) on ethanol-induced damage in rat liver. Chronic ethanol administration (6 g kg(-1) day(-1) x 60 days) caused liver damage that was manifested by excessive formation of thiobarbituric-acid-reactive substances, lipid hydroperoxides, and conjugated dienes, the end products of lipid peroxidation, and significant elevation of protein carbonyl groups and diminution of sulfhydryl groups, a marker of protein oxidation. Decreased activities of enzymic and non-enzymic antioxidant levels and decreased levels of thiol groups (both non-protein and protein) were observed in ethanol-treated rats. Further, ethanol significantly increased the accumulation of 4-hydroxynonenal protein adducts, nitrated and oxidized proteins in liver which was evidenced by immunohistochemistry. Administration of FPEt to ethanol-fed rats (200 mg kg(-1) day(-1)) significantly reduced the levels of lipid peroxidation products and protein carbonyl content, increased the activities of antioxidant enzymes, and restored the levels of thiol groups. The effects of FPEt were comparable with those of a positive control, silymarin. These findings show that FPEt ameliorates the pathological liver changes induced by chronic ethanol feeding.

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Section: Discussionmentioning

confidence: 99%

Protective action of fenugreek (Trigonella foenum graecum) seed polyphenols against alcohol-induced protein and lipid damage in rat liver

2008

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“…The lipid-lowering effect of fenugreek seeds is demonstrated in diabetes (Sauvaire et al 1991;Sharma et al 1991Sharma et al , 1996 and in atherosclerosis (Khosla et al 1995). These authors attributed the effect to its ability to increase bile acid synthesis and to retard increased cholesterol absorption (Stark and Madar 1993).…”

Section: Discussionmentioning

confidence: 99%

Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver

2007

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Chronic alcoholism is associated with fatty liver and fibrosis characterized by collagen accumulation. Seeds of fenugreek, an annual herb, are reported to possess hepatoprotective activity. The study aims to investigate the effects of fenugreek seed polyphenol extract (FPEt) on liver lipids and collagen in experimental hepatotoxic rats. Hepatotoxicity was induced in male albino Wistar rats by administrating ethanol (6 g/kg per day) for 30 days. Control rats were given isocaloric glucose solution. FPEt was co-administered with ethanol at a dose of 200 mg/kg per day for the next 30 days. Silymarin was used as a positive control. Ethanol treatment caused increase in plasma and liver lipids, together with alterations in collagen content and properties. Administration of FPEt to alcohol-fed rats significantly improved lipid profile and reduced collagen content, crosslinking, aldehyde content and peroxidation. The effects were comparable with that of silymarin. FPEt administration had a positive influence on both lipid profile and on the quantitative and qualitative properties of collagen in alcoholic liver disease. The protective effect is presumably due to the bioactive phytochemicals in fenugreek seeds.

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“…Hyperlipidemia is a recognized consequence of diabetes mellitus (Sharma et al, 1996), demonstrated by the elevated levels of tissue cholesterol, phospholipids and free fatty acids (Chorvathova et al, 1993;Bopanna et al, 1997;Stanely Mainzen Prince et al, 1999). Administration of alcoholic JSEt normalized serum and tissue lipids, secondary to the diabetic state.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic and antihyperlipidaemic effect of alcoholic Syzigium cumini seeds in alloxan induced diabetic albino rats

Prince

Kamalakkannan

Menon

2004

Journal of Ethnopharmacology

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Hypolipidaemic Effect of Fenugreek Seeds: a Chronic Study in Non-insulin Dependent Diabetic Patients

Cited by 79 publications

References 11 publications

Protective action of fenugreek (Trigonella foenum graecum) seed polyphenols against alcohol-induced protein and lipid damage in rat liver

Protective action of fenugreek (Trigonella foenum graecum) seed polyphenols against alcohol-induced protein and lipid damage in rat liver

Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver

Antidiabetic and antihyperlipidaemic effect of alcoholic Syzigium cumini seeds in alloxan induced diabetic albino rats

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