Hypogonadism, Quadriceps Weakness, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease

Vliet, Monique van; Spruit, Martijn A.; Verleden, Geert; Kasran, Ahmad; Herck, Erik Van; Pitta, Fábio; Bouillon, Roger; Decramer, Marc

doi:10.1164/rccm.200501-114oc

Cited by 127 publications

(111 citation statements)

References 69 publications

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“…Low testosterone levels have been observed in patients with COPD (365)(366)(367)(368)(369) (368). In contrast, Van Vliet and colleagues observed that quadriceps strength, but not wholebody exercise tolerance, was related to low circulating testosterone levels (365).…”

Section: Mechanisms Of Limb Muscle Dysfunction In Copdmentioning

confidence: 99%

An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease

Maltais¹,

Decramer²,

Casaburi³

et al. 2014

Am J Respir Crit Care Med

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866

1,033

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Section: Mechanisms Of Limb Muscle Dysfunction In Copdmentioning

confidence: 99%

An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease

Maltais¹,

Decramer²,

Casaburi³

et al. 2014

Am J Respir Crit Care Med

Self Cite

866

1,033

View full text Add to dashboard Cite

“…With respect to reproducibility in the short term, there have only been a few studies with small samples of patients to suggest that this is indeed the case [424]. In terms of the influence of quadriceps muscle function on the health outcome of COPD patients, it is known that patients with moderate-to-severe COPD who had been admitted to hospital at least twice in the year prior to the study had significantly lower isometric quadriceps muscle force than those without hospital admission [419].…”

Section: Measurement Of Quadriceps Muscle Functionmentioning

confidence: 99%

Outcomes for COPD pharmacological trials: from lung function to biomarkers

Cazzola¹,

MacNee²,

Martínez³

et al. 2008

European Respiratory Journal

744

566

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“…Indeed, astronauts lose as much bone mass in a 1-month spaceflight as postmenopausal females in 1 yr [43]. In addition, COPD patients have been shown to be physically inactive compared with age-matched healthy subjects [44].…”

Section: Correlates Of Osteoporosis In Copdmentioning

confidence: 99%

Current status of research on osteoporosis in COPD: a systematic review

Graat‐Verboom

Wouters²,

Smeenk³

et al. 2009

European Respiratory Journal

248

218

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Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of osteoporosis. However, the prevalence, correlates and effectiveness of treatment of osteoporosis in COPD patients remain unclear.We performed a systematic review of the literature to answer three questions. 1) What is the prevalence of osteoporosis in COPD? 2) What are identified correlates of osteoporosis in COPD? 3) What are the effects of treatment of osteoporosis in COPD? A computerised literature search in MEDLINE/PubMed and the Cochrane database was carried out. In addition, reference lists were searched by hand and authors were contacted if necessary.The prevalence of osteoporosis and osteopenia varied 9-69% and 27-67%, respectively. Prevalence of osteoporosis was generally higher than in healthy subjects and some other chronic lung diseases. Correlates of osteoporosis in COPD are mainly measures of body composition, disease severity and the use of corticosteroids, although causality has not been proven. Effects of treatment of osteoporosis have not been investigated in samples consisting of COPD patients only.Longitudinal follow-up to assess determinants of osteoporosis in COPD and randomised placebo-controlled trials on the effects of treatment of osteoporosis in patients with COPD only are warranted.

show abstract

Hypogonadism, Quadriceps Weakness, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease

Abstract: In contrast to exercise intolerance, quadriceps muscle weakness is related to low circulating levels of testosterone in men with COPD.

Cited by 127 publications

References 69 publications

An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease

An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease

Outcomes for COPD pharmacological trials: from lung function to biomarkers

Current status of research on osteoporosis in COPD: a systematic review

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