Current status of research on osteoporosis in COPD: a systematic review

Abstract

Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of osteoporosis. However, the prevalence, correlates and effectiveness of treatment of osteoporosis in COPD patients remain unclear.We performed a systematic review of the literature to answer three questions. 1) What is the prevalence of osteoporosis in COPD? 2) What are identified correlates of osteoporosis in COPD? 3) What are the effects of treatment of osteoporosis in COPD? A computerised literature search in MEDLINE/PubMed and the Cochrane database was carried out. In addition, reference lists were searched by hand and authors were contacted if necessary.The prevalence of osteoporosis and osteopenia varied 9-69% and 27-67%, respectively. Prevalence of osteoporosis was generally higher than in healthy subjects and some other chronic lung diseases. Correlates of osteoporosis in COPD are mainly measures of body composition, disease severity and the use of corticosteroids, although causality has not been proven. Effects of treatment of osteoporosis have not been investigated in samples consisting of COPD patients only.Longitudinal follow-up to assess determinants of osteoporosis in COPD and randomised placebo-controlled trials on the effects of treatment of osteoporosis in patients with COPD only are warranted.

A review of lifestyle, smoking and other modifiable risk factors for osteoporotic fractures

“…However, the prevalence of osteoporosis in patients with a long-term smoking history, leading to COPD, has been reported as high as 69% depending on the clinical setting and methodology. 40 Patients often present with additional risk factors of osteoporosis such as the use of corticosteroids, as opposed to smokers with no COPD diagnosis. As severity of COPD progresses, the proportion of patients with osteoporosis increases.…”

Measurement of bone mineral density in stable COPD patients using ultrasound densitometry: prevention is better than cure

“…The COPD patients with osteoporosis had lower FEV1 and BMI values than the patients without osteoporosis. 22 In a retrospective review on 234 male patients referred for osteoporosis, revealed that COPD was the leading cause of secondary osteoporosis. 23 In the current study, out of total number of COPD (n=50), 27 (54%) patients (18 males and 9 females) had osteopenia and 14 (28%) patients (10 males and 4 females) had osteoporosis.…”

Difficulty of Copd Predicting as a Challenge to Modern Clinical Pulmonology

“…Не-сколько исследований показало снижение мине-ральной костной плотности ткани вне зависимости от тяжести течения ХОБЛ [2,19,20,45]. Другое ис-следование выявило остеопороз у 75% пациентов с 4 стадией ХОБЛ.…”

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