Hypoglycemic seizures and epilepsy in type I diabetes mellitus

Falip, Mercé; Miró, Júlia; Carreño, Mar; Jaraba, Sònia; Becerra, Juan Luís; Cayuela, Núria; Maraver, Manuel Pérez; Graus, Francesc

doi:10.1016/j.jns.2014.08.024

Cited by 14 publications

(8 citation statements)

References 17 publications

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“…More clinical-based studies are needed to clarify the clinical phenotype of epilepsy in TIDM. Hypoglycemia induced seizures appear to be rare [63]. Nevertheless some confounding cannot be ruled out as it is not known how the diagnosis of epilepsy was established in the studies using administrative databases.…”

Section: Type 1 Diabetes Mellitus (Tidm)mentioning

confidence: 99%

Seizures as a clinical manifestation in somatic autoimmune disorders

Amanat

Thijs

Salehi

et al. 2019

Seizure

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A B S T R A C TThe risk of epileptic seizures seems increased in several systemic autoimmune disorders including systemic lupus erythematosus, type 1 diabetes mellitus, myasthenia gravis, celiac disease, rheumatoid arthritis, Hashimoto's encephalopathy, psoriasis, multiple sclerosis, neuromyelitis optica, and bullous pemphigoid. Immune dysfunction may be partly responsible for this association. Elevated levels of pro-inflammatory cytokines, autoantibodies seen in these autoimmune disorders and antibodies against neuronal antigens may contribute to the etiopathogenesis of seizures and epilepsy associated to immune conditions. Other unknown factors, the effect of different co-morbid conditions of epilepsy as well as shared risk factors such as common etiological factors, environmental triggers, or a common genetic predisposition may also explain the association. We review different autoimmune disorders which may present with co-morbid seizures and discuss possible underlying mechanisms of this co-occurrence focusing on a potential role of immune system dysfunction.

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Section: Type 1 Diabetes Mellitus (Tidm)mentioning

confidence: 99%

Seizures as a clinical manifestation in somatic autoimmune disorders

Amanat

Thijs

Salehi

et al. 2019

Seizure

View full text Add to dashboard Cite

show abstract

“…O'Connell et al 16 found no frequency difference between epilepsy in children and adolescents with or without IDDM. Merce et al 17 )2014( did not share the hypothesis that epilepsy is more frequent in children with IDDM. While these 2 studies showed contrasting results, the mainstream consensus based on many different international studies is that there is a definite increase in epilepsy prevalence in IDDM-affected children.…”

Section: Discussionmentioning

confidence: 97%

“…20 Children with IDDM have an increased risk of seizures at glycemic extremes-both hypoglycemia and hyperglycemia. 17 Hypoglycemia used to be a common problem in IDDM patients, and the relationship between hypoglycemia and epilepsy is complicated. Diabetes etiology and metabolic abnormalities of hypo and hyperglycemias may damage the human CNS and trigger subsequent seizures.…”

Section: Discussionmentioning

confidence: 99%

Epilepsy in patients with insulin-dependent diabetes and relation to glutamic acid decarboxylase 65

Mahmoud

Abdelmagid

AlGhofely

et al. 2020

NSJ

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“…Yakın zamanda yapılan bir çalışmada, hipoglisemik nöbetlerin (%0.87) ve epilepsinin (%0.87) T1DM'de nadir görüldüğünü ve anti-GAD antikorları-nın genel popülasyondan farklı olmadığını bildirmişlerdir. [111] Epileptik nöbetlerin tedavisinde metabolik kontrolün sağ-lanmasının yanısıra antiepileptik tedaviler de kullanılabilir. GAD antikorunun pozitifliği ve epilepsi birlikteliğinin olduğu bazı olgularda immünsupresif tedavilerin etkin olabileceği bildirilmiştir.…”

Section: Hashimoto Tiroiditiunclassified